chr10:87863113:> Detail (hg38) (PTEN)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr10:89,622,870-89,731,687 |
| hg38 | chr10:87,863,113-87,971,930 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| endometrial carcinoma | Everolimus | B |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 23238879 | Detail |
| head and neck cancer | Pictilisib,Tanespimycin | D |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 2 | 25855885 | Detail |
| head and neck squamous cell carcinoma | Taselisib | D |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 26589432 | Detail |
| cancer | Ipatasertib | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 23287563 | Detail |
| prostate cancer | Alpelisib,Enzalutamide,PI3Kbeta Inhibitor AZD8186 | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 25544636 | Detail |
| glioblastoma | C |
Diagnostic
|
Supports
|
Positive | Somatic | 2 | 9331072 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Tumors from 35 patients (12 with partial response or stable disease) with advanced endometrial carci... | CIViC Evidence | Detail |
| Analysis of drug response data from the Sanger center cell line screen. Cell lines with either PI3K ... | CIViC Evidence | Detail |
| In a panel of 26 HNSCC cell lines tested for sensitivity to taselisib (an alpha, delta and gamma iso... | CIViC Evidence | Detail |
| IC50 for the pan-Akt inhibitor ipatasertib (GDC-0068) was determined over a panel of 100 cancer cell... | CIViC Evidence | Detail |
| Castrated mice bearing androgen-sensitive human prostate adenocarcinomas (LNCaP tumors) were treated... | CIViC Evidence | Detail |
| Rasheed et al. identified that PTEN mutations occur with significantly greater frequency in adults w... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr10:87,863,113-87,971,930
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- MUTATION
- Transcript 1 (CIViC Variant)
- ENST00000371953.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/510
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