chr4:105145875:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr4:106,067,032-106,200,973 
hg38 chr4:105,145,875-105,279,816

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.008 Congenital chromosomal disease A 14-yr-old male was admitted to our hospital with MDS and the chromosomal abnor... BeFree 25130056 Detail
0.008 Congenital chromosomal disease Karyotype analysis was performed in 179 patients with AML or MDS with the differ... BeFree 26214902 Detail
<0.001 colitis Tet2-deficient mice were more susceptible to endotoxin shock and dextran-sulfate... BeFree 26287468 Detail
<0.001 colorectal carcinoma Genome-wide analyses show that promoters marked by 5hmC in normal tissue, and th... BeFree 25853800 Detail
<0.001 Presenile dementia NA BeFree Detail
<0.001 dystonia NA BeFree Detail
<0.001 Eosinophilia NA BeFree Detail
<0.001 Glioma NA BeFree Detail
<0.001 Focal glomerulosclerosis NA BeFree Detail
<0.001 Glycogen Storage Disease Type VI NA BeFree Detail
<0.001 Graft-vs-Host Disease NA BeFree Detail
0.002 Hematological Disease The methylcytosine dioxygenase TET2 is frequently mutated in hematological disor... BeFree 25886910 Detail
<0.001 Hepatic Vein Thrombosis NA BeFree Detail
<0.001 HIV Infections NA BeFree Detail
0.121 Angioimmunoblastic Lymphadenopathy TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lympho... BeFree,CTD_human 25501021 Detail
<0.001 Immune System Diseases NA BeFree Detail
0.009 leukemia RUNX1 translocations and amplifications have been implicated in acute myeloblast... BeFree,GAD 24912843 Detail
0.009 leukemia Tet2 mutations are drivers in haematological malignancies but Tet1 had an oncoge... BeFree,GAD 25179374 Detail
0.009 leukemia Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 down... BeFree,GAD 25362856 Detail
0.009 leukemia WT1 recruits TET2 to regulate its target gene expression and suppress leukemia c... BeFree,GAD 25601757 Detail
0.009 leukemia We conclude that leukemia-associated TET2 mutations affect DNA methylation at NC... BeFree,GAD 25972343 Detail
<0.001 chronic lymphocytic leukemia TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence... BeFree 24693539 Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
0.061 Leukemia, Myelocytic, Acute Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutation... BeFree,GAD 24524305 Detail
0.061 Leukemia, Myelocytic, Acute A recent report in Nature now demonstrates that a specific mutation in mouse col... BeFree,GAD 24589711 Detail
0.061 Leukemia, Myelocytic, Acute In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles de... BeFree,GAD 24845343 Detail
0.061 Leukemia, Myelocytic, Acute The total coding region of TET2 was analyzed by direct sequencing in 215 CN-AML ... BeFree,GAD 24898826 Detail
0.061 Leukemia, Myelocytic, Acute Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes ... BeFree,GAD 24986689 Detail
0.061 Leukemia, Myelocytic, Acute Although the frequency of evolution from hypocellular MDS to AML is low, our res... BeFree,GAD 25180186 Detail
0.061 Leukemia, Myelocytic, Acute A significantly decreased TET2 expression was observed in bone marrow cells from... BeFree,GAD 25200248 Detail
0.061 Leukemia, Myelocytic, Acute DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TE... BeFree,GAD 25482556 Detail
0.061 Leukemia, Myelocytic, Acute TP53 was the most common mutated gene in t-MDS (35.7%) as well as t-AML (33.3%),... BeFree,GAD 25573287 Detail
0.061 Leukemia, Myelocytic, Acute Our results also provide an explanation for the mutual exclusivity of WT1 and TE... BeFree,GAD 25601757 Detail
0.061 Leukemia, Myelocytic, Acute In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an... BeFree,GAD 25699704 Detail
0.061 Leukemia, Myelocytic, Acute What came first: MDS or AML? BeFree,GAD 25721039 Detail
0.061 Leukemia, Myelocytic, Acute The methylcytosine dioxygenase TET2 is frequently mutated in hematological disor... BeFree,GAD 25886910 Detail
0.061 Leukemia, Myelocytic, Acute This TP53 mutation pattern was strikingly similar to that observed in de novo MD... BeFree,GAD 25952993 Detail
0.061 Leukemia, Myelocytic, Acute In addition, mutations in epigenetic regulators such as DNMT3A, TET2, and ASXL1 ... BeFree,GAD 26118500 Detail
0.061 Leukemia, Myelocytic, Acute Karyotype analysis was performed in 179 patients with AML or MDS with the differ... BeFree,GAD 26214902 Detail
0.002 myeloid leukemia TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well ... BeFree 25972343 Detail
0.002 Myeloid Leukemia, Chronic NA BeFree Detail
0.020 Leukemia, Myelomonocytic, Chronic The study group included 13 MPN and four MDS/MPN patients (seven polycythemia ve... BeFree,GAD 24845343 Detail
0.020 Leukemia, Myelomonocytic, Chronic TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis ... BeFree,GAD 25510268 Detail
0.020 Leukemia, Myelomonocytic, Chronic TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcript... BeFree,GAD 25972343 Detail
0.001 acute promyelocytic leukemia NA BeFree Detail
0.001 leukopenia NA BeFree Detail
<0.001 lymphedema Heterozygous germline mutations in the zinc finger transcription factor GATA2 ha... BeFree 26214525 Detail
0.002 lymphoma NA BeFree Detail
<0.001 Lymphoma, Non-Hodgkin NA BeFree Detail
0.001 mastocytosis Where TET2 and SRSF2-P95 mutation both correlated with advanced disease phenotyp... BeFree 24389310 Detail
0.001 mastocytosis Loss of function of TET2 cooperates with constitutively active KIT in murine and... BeFree 24788138 Detail
0.121 melanoma Overexpression of Tet2 in melanoma cells re-established the 5hmC landscape and s... BeFree,GWASCAT 25179374 Detail
0.004 Monosomy NA BeFree Detail
<0.001 Movement Disorders The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDR... BeFree 25487881 Detail
0.001 multiple myeloma NA BeFree Detail
0.003 Myelodysplasia Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm charact... BeFree 24970933 Detail
0.003 Myelodysplasia We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain... BeFree 25512612 Detail
0.121 myelofibrosis NA BeFree,ORPHANET Detail
0.012 Myeloproliferative disease In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles de... BeFree,GAD 24845343 Detail
<0.001 Neoplasm Metastasis NA BeFree Detail
<0.001 nephroblastoma NA BeFree Detail
0.128 polycythemia vera The study group included 13 MPN and four MDS/MPN patients (seven polycythemia ve... BeFree,GAD,ORPHANET 24845343 Detail
<0.001 Precancerous Conditions NA BeFree Detail
0.019 Preleukemia Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm charact... BeFree,GAD 24970933 Detail
0.019 Preleukemia Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. BeFree,GAD 25200248 Detail
0.019 Preleukemia The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in pat... BeFree,GAD 25481243 Detail
0.019 Preleukemia A zebrafish model of myelodysplastic syndrome produced through tet2 genomic edit... BeFree,GAD 25512612 Detail
0.019 Preleukemia Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently... BeFree,GAD 25619630 Detail
0.019 Preleukemia TET2 mutations predict response to hypomethylating agents in myelodysplastic syn... BeFree,GAD 25697572 Detail
0.019 Preleukemia Heterozygous germline mutations in the zinc finger transcription factor GATA2 ha... BeFree,GAD 26214525 Detail
0.120 Prostatic Neoplasms NA CTD_human Detail
0.120 Sezary syndrome NA CTD_human Detail
0.127 Thrombocythemia, Essential The study group included 13 MPN and four MDS/MPN patients (seven polycythemia ve... BeFree,GAD,ORPHANET 24845343 Detail
<0.001 thymoma Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n =... BeFree 25482724 Detail
0.002 Chromosomal translocation NA GAD Detail
<0.001 Trisomy NA BeFree Detail
<0.001 urticaria pigmentosa Loss of function of TET2 cooperates with constitutively active KIT in murine and... BeFree 24788138 Detail
<0.001 B-Cell Lymphomas NA BeFree Detail
<0.001 diffuse large B-cell lymphoma NA BeFree Detail
<0.001 Lymphoma, Large-Cell, Follicular NA BeFree Detail
<0.001 T-Cell Lymphoma Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-lik... BeFree 25501021 Detail
0.121 peripheral T-cell lymphoma TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lympho... BeFree,CTD_human 25501021 Detail
<0.001 Liver failure NA BeFree Detail
0.003 acute leukemia NA BeFree Detail
0.001 Monocytosis Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm charact... BeFree 24970933 Detail
<0.001 Tumor Progression Overexpression of Tet2 in melanoma cells re-established the 5hmC landscape and s... BeFree 25179374 Detail
<0.001 thymic carcinoma Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n =... BeFree 25482724 Detail
<0.001 Adult Acute Myeloblastic Leukemia NA BeFree Detail
<0.001 pediatric acute myeloblastic leukemia NA BeFree Detail
0.005 Mastocytosis, Systemic We exploit these findings to validate a combination treatment strategy targeting... BeFree,GAD 24788138 Detail
0.005 Mastocytosis, Systemic All patients with (A)SM-AHNMD (n=12) carried 1-4 (median 3) additional mutations... BeFree,GAD 25567135 Detail
<0.001 secondary myelofibrosis Among them, five patients (two PV, two MPN-U, and one MDS/MPN-U) progressed to M... BeFree 24845343 Detail
<0.001 Neoplasm, Residual NA BeFree Detail
0.002 Miller Dieker syndrome NA BeFree Detail
<0.001 Renal glomerular disease NA BeFree Detail
<0.001 Acquired aplastic anemia NA BeFree Detail
<0.001 Philadelphia chromosome positive chronic myelogenous leukemia Few patients in remission of Ph-positive chronic myelogenous leukemia (CML) deve... BeFree 25631405 Detail
<0.001 Refractory anemia with excess blasts in transformation (clinical) NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
0.002 secondary acute myeloid leukemia NA BeFree Detail
<0.001 de novo myelodysplastic syndromes NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
0.002 juvenile myelomonocytic leukemia NA BeFree Detail
<0.001 prediabetes syndrome NA BeFree Detail
0.005 Malignant neoplasm of prostate NA BeFree,GAD Detail
<0.001 Hematopoietic Neoplasms TET2 is involved in a variety of hematopoietic malignancies, mainly in myeloid m... BeFree 24693539 Detail
0.003 Hematologic Neoplasms NA BeFree Detail
<0.001 Dystonia Disorders NA BeFree Detail
<0.001 Overlap syndrome NA BeFree Detail
0.003 Chromosome 8, trisomy The aim of our study was 1) to define if the amplification of c-MYC, MLL and RUN... BeFree 26214902 Detail
<0.001 Enteropathy-Associated T-Cell Lymphoma NA BeFree Detail
<0.001 endometrial carcinoma NA BeFree Detail
<0.001 dementia NA BeFree Detail
<0.001 Severe depression NA BeFree Detail
<0.001 Carcinogenesis The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by... BeFree 25601757 Detail
0.002 Leukemogenesis Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enha... BeFree 25886910 Detail
<0.001 Lymphoid neoplasm Most mutations of TET2 have been identified in myeloid disorders, but some have ... BeFree 24693539 Detail
0.020 Leukemia, Myelomonocytic, Chronic TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (... BeFree 19474426 Detail
<0.001 prostate carcinoma NA BeFree Detail
<0.001 thrombocytosis The remaining cases usually lack the JAK2(V617F)mutation, have a platelet count ... BeFree 21350094 Detail
0.002 juvenile myelomonocytic leukemia Mutations in TET2, RUNX1 and JAK2(V617F) are involved in myelodysplastic and/or ... BeFree 20955399 Detail
<0.001 Epithelial ovarian cancer Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer. BeFree 25827305 Detail
0.002 secondary acute myeloid leukemia TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (... BeFree 19474426 Detail
0.008 Primary myelofibrosis We have studied the mutational status of TET2 (complete coding region), ASXL1 (e... BeFree 21904853 Detail
0.061 Leukemia, Myelocytic, Acute Among five patients diagnosed with MDS/MPN-U, three patients harboured RUNX1 (AM... BeFree 22571758 Detail
0.002 Myeloid Leukemia, Chronic Previous studies have reported FLT3 mutation in as many as 9.2% of myeloprolifer... BeFree 23846442 Detail
0.002 breast carcinoma Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 down... BeFree 25362856 Detail
0.002 breast carcinoma The efficacy of the software is verified through MDS and clustering and tested w... BeFree 25905921 Detail
0.128 polycythemia vera We have studied the mutational status of TET2 (complete coding region), ASXL1 (e... BeFree 21904853 Detail
0.012 Myeloproliferative disease TET2 defects were present in hematopoietic stem cells and preceded the JAK2 V617... BeFree 19474426 Detail
<0.001 Glycogen Storage Disease Type VI In a patient with 2 TET2 mutations, the analysis of 5 blood samples at different... BeFree 19564637 Detail
0.001 5q-syndrome NA BeFree Detail
<0.001 Refractory cytopenia with multilineage dysplasia TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cy... BeFree 26277372 Detail
<0.001 thrombocytosis NA BeFree Detail
<0.001 Leukemia secondary NA BeFree Detail
<0.001 Budd-Chiari syndrome NA BeFree Detail
0.001 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative The study group included 13 MPN and four MDS/MPN patients (seven polycythemia ve... BeFree 24845343 Detail
0.001 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative According to the 2008 WHO classification, the category of myelodysplastic/myelop... BeFree 25212680 Detail
0.120 Acute myeloid leukemia with multilineage dysplasia NA ORPHANET Detail
0.002 Chronic myeloproliferative disorder In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles de... BeFree 24845343 Detail
0.001 Myelodysplastic Syndrome with Isolated del(5q) NA BeFree Detail
0.001 Therapy-related myelodysplastic syndrome TP53 was the most common mutated gene in t-MDS (35.7%) as well as t-AML (33.3%),... BeFree 25573287 Detail
0.004 Myelodysplastic-Myeloproliferative Diseases Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neopla... BeFree 24845343 Detail
0.004 Myelodysplastic-Myeloproliferative Diseases According to the 2008 WHO classification, the category of myelodysplastic/myelop... BeFree 25212680 Detail
<0.001 blastic plasmacytoid dendritic cell neoplasm NA BeFree Detail
<0.001 Eosinophilic disorder NA BeFree Detail
<0.001 Refractory anemia with excess blasts I In MDS, TET2 expression was significantly reduced in RAEB-1/RAEB-2 compared to o... BeFree 25200248 Detail
<0.001 Refractory anemia with excess blasts II NA BeFree Detail
<0.001 Thymoma, type C Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n =... BeFree 25482724 Detail
<0.001 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome NA BeFree Detail
<0.001 Chronic Myelomonocytic Leukemia-1 NA BeFree Detail
0.001 Treatment related acute myeloid leukaemia NA BeFree Detail
<0.001 colorectal cancer Genome-wide analyses show that promoters marked by 5hmC in normal tissue, and th... BeFree 25853800 Detail
<0.001 Disorder characterized by eosinophilia NA BeFree Detail
<0.001 Milroy Disease Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently... BeFree 25619630 Detail
0.001 Chromosome 5, trisomy 5q NA BeFree Detail
<0.001 MYELOID TUMOR SUPPRESSOR NA BeFree Detail
<0.001 campomelic dysplasia NA BeFree Detail
<0.001 uterine corpus cancer NA BeFree Detail
0.003 Precursor Cell Lymphoblastic Leukemia Lymphoma NA BeFree,GAD Detail
<0.001 Extramedullary Hematopoiesis (disorder) NA BeFree Detail
<0.001 Refractory cytopenia of childhood TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cy... BeFree 26277372 Detail
<0.001 Refractory anemia with ring sideroblasts associated with marked thrombocytosis NA BeFree Detail
0.002 myeloid neoplasm TET2 is involved in a variety of hematopoietic malignancies, mainly in myeloid m... BeFree 24693539 Detail
0.002 myeloid neoplasm Mutations of the Ten-Eleven-Translocation 2 (TET2) gene have been identified in ... BeFree 24898826 Detail
0.002 myeloid neoplasm Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm charact... BeFree 24970933 Detail
0.002 myeloid neoplasm TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lympho... BeFree 25501021 Detail
0.002 myeloid neoplasm TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis ... BeFree 25510268 Detail
0.002 myeloid neoplasm Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently... BeFree 25619630 Detail
0.001 Refractory anemia, without ringed sideroblasts, without excess blasts NA BeFree Detail
<0.001 Emberger syndrome Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently... BeFree 25619630 Detail
0.144 myelodysplastic syndrome Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. BeFree,CTD_human,GAD 25200248 Detail
0.144 myelodysplastic syndrome The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in pat... BeFree,CTD_human,GAD 25481243 Detail
0.144 myelodysplastic syndrome A zebrafish model of myelodysplastic syndrome produced through tet2 genomic edit... BeFree,CTD_human,GAD 25512612 Detail
0.144 myelodysplastic syndrome Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently... BeFree,CTD_human,GAD 25619630 Detail
0.144 myelodysplastic syndrome TET2 mutations predict response to hypomethylating agents in myelodysplastic syn... BeFree,CTD_human,GAD 25697572 Detail
0.144 myelodysplastic syndrome Heterozygous germline mutations in the zinc finger transcription factor GATA2 ha... BeFree,CTD_human,GAD 26214525 Detail
<0.001 Cytogenetically normal acute myeloid leukemia TET2 gene mutation is unfavorable prognostic factor in cytogenetically normal ac... BeFree 24859829 Detail
<0.001 Cytogenetically normal acute myeloid leukemia TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implic... BeFree 24898826 Detail
0.008 Primary myelofibrosis NA BeFree,GAD Detail
0.002 Alcoholic Intoxication, Chronic NA GAD Detail
0.002 anemia We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain... BeFree 25512612 Detail
0.001 aplastic anemia NA BeFree Detail
0.121 Refractory anemias NA BeFree,ORPHANET Detail
0.124 Refractory anaemia with excess blasts NA BeFree,ORPHANET Detail
<0.001 Autoimmune Diseases Consequently, Tet1 and Tet2 deletion led to Foxp3 hypermethylation, impaired Tre... BeFree 26275994 Detail
0.003 Blast Phase NA BeFree,GAD Detail
0.122 Malignant neoplasm of breast Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 down... BeFree,GWASCAT 25362856 Detail
0.122 Malignant neoplasm of breast The efficacy of the software is verified through MDS and clustering and tested w... BeFree,GWASCAT 25905921 Detail
<0.001 Malignant neoplasm of endometrium NA BeFree Detail
0.121 renal cell carcinoma One out of 19 pediatric patients with RCC was a carrier of a TET2 mutation. BeFree,CTD_human 26277372 Detail
Annotation

Annotations

DescrptionSourceLinks
A 14-yr-old male was admitted to our hospital with MDS and the chromosomal abnormality 45,XY,der(5;1... DisGeNET Detail
Karyotype analysis was performed in 179 patients with AML or MDS with the different chromosomal aber... DisGeNET Detail
Tet2-deficient mice were more susceptible to endotoxin shock and dextran-sulfate-sodium-induced coli... DisGeNET Detail
Genome-wide analyses show that promoters marked by 5hmC in normal tissue, and those identified as TE... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acut... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma that harbor folli... DisGeNET Detail
NA DisGeNET Detail
RUNX1 translocations and amplifications have been implicated in acute myeloblastic leukemia, acute l... DisGeNET Detail
Tet2 mutations are drivers in haematological malignancies but Tet1 had an oncogenic role in MLL-rear... DisGeNET Detail
Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 downregulation has been ... DisGeNET Detail
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. DisGeNET Detail
We conclude that leukemia-associated TET2 mutations affect DNA methylation at NCGI regions containin... DisGeNET Detail
TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations. DisGeNET Detail
NA DisGeNET Detail
Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutations in adult patients ... DisGeNET Detail
A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing ost... DisGeNET Detail
In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles decreased according to... DisGeNET Detail
The total coding region of TET2 was analyzed by direct sequencing in 215 CN-AML patients younger tha... DisGeNET Detail
Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA ... DisGeNET Detail
Although the frequency of evolution from hypocellular MDS to AML is low, our results suggest that so... DisGeNET Detail
A significantly decreased TET2 expression was observed in bone marrow cells from AML (n = 53) and pa... DisGeNET Detail
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute... DisGeNET Detail
TP53 was the most common mutated gene in t-MDS (35.7%) as well as t-AML (33.3%), significantly highe... DisGeNET Detail
Our results also provide an explanation for the mutual exclusivity of WT1 and TET2 mutations in AML,... DisGeNET Detail
In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature o... DisGeNET Detail
What came first: MDS or AML? DisGeNET Detail
The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acut... DisGeNET Detail
This TP53 mutation pattern was strikingly similar to that observed in de novo MDS/AML. DisGeNET Detail
In addition, mutations in epigenetic regulators such as DNMT3A, TET2, and ASXL1 have recently been f... DisGeNET Detail
Karyotype analysis was performed in 179 patients with AML or MDS with the different chromosomal aber... DisGeNET Detail
TET2 enzymatically converts 5-methylcytosine to 5-hydroxymethylcytosine as well as other covalently ... DisGeNET Detail
NA DisGeNET Detail
The study group included 13 MPN and four MDS/MPN patients (seven polycythemia vera (PV); four essent... DisGeNET Detail
TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis of myeloid malignanc... DisGeNET Detail
TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding S... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been sho... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Where TET2 and SRSF2-P95 mutation both correlated with advanced disease phenotypes, SRSF2-P95 hotspo... DisGeNET Detail
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mas... DisGeNET Detail
Overexpression of Tet2 in melanoma cells re-established the 5hmC landscape and suppressed cancer pro... DisGeNET Detail
NA DisGeNET Detail
The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the Hoehn and Ya... DisGeNET Detail
NA DisGeNET Detail
Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm characterized by myelodyspl... DisGeNET Detail
We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain. tet2(m/m) (homozyg... DisGeNET Detail
NA DisGeNET Detail
In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles decreased according to... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The study group included 13 MPN and four MDS/MPN patients (seven polycythemia vera (PV); four essent... DisGeNET Detail
NA DisGeNET Detail
Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm characterized by myelodyspl... DisGeNET Detail
Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. DisGeNET Detail
The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysp... DisGeNET Detail
A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. DisGeNET Detail
Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently described MonoMAC s... DisGeNET Detail
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.Blood... DisGeNET Detail
Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been sho... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The study group included 13 MPN and four MDS/MPN patients (seven polycythemia vera (PV); four essent... DisGeNET Detail
Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n = 2; 4%)], chromatin ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mas... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice. DisGeNET Detail
TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma that harbor folli... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm characterized by myelodyspl... DisGeNET Detail
Overexpression of Tet2 in melanoma cells re-established the 5hmC landscape and suppressed cancer pro... DisGeNET Detail
Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n = 2; 4%)], chromatin ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We exploit these findings to validate a combination treatment strategy targeting the epigenetic dere... DisGeNET Detail
All patients with (A)SM-AHNMD (n=12) carried 1-4 (median 3) additional mutations in 11 genes tested,... DisGeNET Detail
Among them, five patients (two PV, two MPN-U, and one MDS/MPN-U) progressed to MF and three patients... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Few patients in remission of Ph-positive chronic myelogenous leukemia (CML) develop Ph-negative MDS/... DisGeNET Detail
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TET2 is involved in a variety of hematopoietic malignancies, mainly in myeloid malignancies. DisGeNET Detail
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The aim of our study was 1) to define if the amplification of c-MYC, MLL and RUNX1 genes is related ... DisGeNET Detail
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The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by modulating DNA meth... DisGeNET Detail
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction ... DisGeNET Detail
Most mutations of TET2 have been identified in myeloid disorders, but some have also recently been d... DisGeNET Detail
TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (19%), in 24 of 198 p... DisGeNET Detail
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The remaining cases usually lack the JAK2(V617F)mutation, have a platelet count less than 600 × 10(3... DisGeNET Detail
Mutations in TET2, RUNX1 and JAK2(V617F) are involved in myelodysplastic and/or myeloproliferative s... DisGeNET Detail
Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer. DisGeNET Detail
TET2 defects were observed in 15 of 81 patients with myelodysplastic syndromes (19%), in 24 of 198 p... DisGeNET Detail
We have studied the mutational status of TET2 (complete coding region), ASXL1 (exon12), IDH1 (R132),... DisGeNET Detail
Among five patients diagnosed with MDS/MPN-U, three patients harboured RUNX1 (AML1) mutations; one c... DisGeNET Detail
Previous studies have reported FLT3 mutation in as many as 9.2% of myeloproliferative neoplasms (MPN... DisGeNET Detail
Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 downregulation has been ... DisGeNET Detail
The efficacy of the software is verified through MDS and clustering and tested with available 11 fam... DisGeNET Detail
We have studied the mutational status of TET2 (complete coding region), ASXL1 (exon12), IDH1 (R132),... DisGeNET Detail
TET2 defects were present in hematopoietic stem cells and preceded the JAK2 V617F mutation in the fi... DisGeNET Detail
In a patient with 2 TET2 mutations, the analysis of 5 blood samples at different phases of her disea... DisGeNET Detail
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TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood... DisGeNET Detail
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The study group included 13 MPN and four MDS/MPN patients (seven polycythemia vera (PV); four essent... DisGeNET Detail
According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplas... DisGeNET Detail
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In one patient (MDS/MPN-U) evolving to AML, the number of JAK2 mutant alleles decreased according to... DisGeNET Detail
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TP53 was the most common mutated gene in t-MDS (35.7%) as well as t-AML (33.3%), significantly highe... DisGeNET Detail
Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) may tr... DisGeNET Detail
According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplas... DisGeNET Detail
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In MDS, TET2 expression was significantly reduced in RAEB-1/RAEB-2 compared to other WHO 2008 classi... DisGeNET Detail
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Genes in histone modification [BAP1 (n = 6; 13%), SETD2 (n = 5; 11%), ASXL1 (n = 2; 4%)], chromatin ... DisGeNET Detail
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Genome-wide analyses show that promoters marked by 5hmC in normal tissue, and those identified as TE... DisGeNET Detail
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Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently described MonoMAC s... DisGeNET Detail
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TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood... DisGeNET Detail
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TET2 is involved in a variety of hematopoietic malignancies, mainly in myeloid malignancies. DisGeNET Detail
Mutations of the Ten-Eleven-Translocation 2 (TET2) gene have been identified in patients with variou... DisGeNET Detail
Comutation of TET2 and SRSF2 was highly predictive of a myeloid neoplasm characterized by myelodyspl... DisGeNET Detail
TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma that harbor folli... DisGeNET Detail
TET2 functions as a bona fide tumor suppressor particularly in the pathogenesis of myeloid malignanc... DisGeNET Detail
Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently described MonoMAC s... DisGeNET Detail
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Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently described MonoMAC s... DisGeNET Detail
Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. DisGeNET Detail
The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysp... DisGeNET Detail
A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. DisGeNET Detail
Guanine-adenine-thymine-adenine 2 (GATA2) mutated disorders include the recently described MonoMAC s... DisGeNET Detail
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.Blood... DisGeNET Detail
Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been sho... DisGeNET Detail
TET2 gene mutation is unfavorable prognostic factor in cytogenetically normal acute myeloid leukemia... DisGeNET Detail
TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolution... DisGeNET Detail
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We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain. tet2(m/m) (homozyg... DisGeNET Detail
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Consequently, Tet1 and Tet2 deletion led to Foxp3 hypermethylation, impaired Treg cell differentiati... DisGeNET Detail
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Genetic mutations of TET2 gene were associated with leukaemia, whereas TET1 downregulation has been ... DisGeNET Detail
The efficacy of the software is verified through MDS and clustering and tested with available 11 fam... DisGeNET Detail
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One out of 19 pediatric patients with RCC was a carrier of a TET2 mutation. DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386626619 dbSNP
Genome
hg38
Position
chr4:105,145,875-105,279,816
Variant Type
snv
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