chr7:140753336:> Detail (hg38) (BRAF)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:140,453,136-140,481,403 |
| hg38 | chr7:140,753,336-140,781,603 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer | Panitumumab,Cetuximab | B |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 25673558 | Detail |
| colorectal cancer | Cetuximab | D |
Predictive
|
Supports
|
Resistance | Somatic | 2 | 22586653 | Detail |
| colorectal cancer | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 19603024 | Detail | |
| colorectal cancer | Oxaliplatin | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 19603024 | Detail |
| colorectal cancer | Irinotecan | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 19603024 | Detail |
| colorectal cancer | Bevacizumab | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 19603024 | Detail |
| colorectal cancer | Cetuximab | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 19603024 | Detail |
| colorectal cancer | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 19603024 | Detail | |
| colorectal cancer | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 4 | 21641636 | Detail | |
| colorectal cancer | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 4 | 24112392 | Detail | |
| cancer | Trametinib | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 22169769 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| A quantitative synthesis was performed on nine studies comparing treatment of metastatic colorectal ... | CIViC Evidence | Detail |
| A cohort of patient-derived xenografts (PDX) from 85 patients with metastatic colorectal cancer was ... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 168 metastatic colorectal cancer patients who received fi... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 100 metastatic colorectal cancer patients who received FO... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 44 metastatic colorectal cancer patients who received FOL... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 97 metastatic colorectal cancer patients who received bev... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 92 metastatic colorectal cancer patients who received cet... | CIViC Evidence | Detail |
| This was a retrospective clinical study of 168 metastatic colorectal cancer patients who received fi... | CIViC Evidence | Detail |
| In the Medical Research Council (MRC) COIN trial, ISRCTN27286448, patients who presented with advanc... | CIViC Evidence | Detail |
| A meta analysis was performed using data from 21 published studies (n = 9885 patients) to assess pro... | CIViC Evidence | Detail |
| In this screen of 218 solid cancer cell lines, BRAF mutations were predictive of response to the MEK... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr7:140,753,336-140,781,603
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- MUTATION
- Transcript 1 (CIViC Variant)
- ENST00000288602.6
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/399
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