IFNAR1 OVEREXPRESSION Detail (hg19) (IFNAR1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr21:34,696,692-34,732,170 |
| hg38 | chr21:33,324,387-33,359,864 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In an in vivo murine model, diosmin (a flavonoid) and interferon-alpha showed synergic anti-melanoma... | MMMP | Detail |
| IFN-alpha2b and thalidomide synergistically inhibit tumor-induced angiogenesis | MMMP | Detail |
| IFN-beta and TRAIL/Apo2L combination treatment had more potent apoptotic and anti-growth effects whe... | MMMP | Detail |
| Adjuvant setting; IFN alone increased survival | MMMP | Detail |
| Metastatic human melanoma cells treated with IFN-beta plus mezerein (phorbol ester analog from the p... | MMMP | Detail |
| This meta-analysis of 8 trials shows no overall survival advantage for the addition of IFN to chemot... | MMMP | Detail |
| Phase III RCT. Setting: advanced disease. No therapeutic benefit was observed by adding INF | MMMP | Detail |
| Despite stabilizing IFNAR, Sorafenib - while inhibiting melanoma cell growth by itself - attenuated ... | MMMP | Detail |
| Pretreatment of 1205Lu cells with MEK1 inhibitor PD098059 noticeably enhanced the anti-proliferative... | MMMP | Detail |
| This drug combination works also in Bcl-2 or Mcl-1 expressing tumors | MMMP | Detail |
| Epigallocatechin-3-gallate (EGCG) sensitizes melanoma cells to interferon induced growth inhibition ... | MMMP | Detail |
| Activation of IFNAR and TLR3 shows synergistic therapeutic potential (inhibition of melanoma cell su... | MMMP | Detail |
| IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor act... | MMMP | Detail |
| Overall response rate: 18% (not greater than expected with DTIC alone) | MMMP | Detail |
| In this phase II trial, no objective responses were noted; three patients demonstrated disease stabi... | MMMP | Detail |
| This phase II RCT showed that addition of IFN to bevacizumab was not associated with clinical benefi... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr21:34,696,692-34,732,170
- Variant Type
- cnv
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