MAP2K7 UNDEREXPRESSION Detail (hg19) (MAP2K7)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr19:7,968,728-7,979,363 |
| hg38 | chr19:7,903,843-7,914,478 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| MEK 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-di... | MMMP | Detail |
| PD98059: selective MEK1-2 inhibitor. Administration of the PD98059-nanoparticles in melanoma-bearing... | MMMP | Detail |
| LY294002 is a PI3K inhibitor. Transgenic mice with constitutively activated RAS were used. Combined ... | MMMP | Detail |
| Rapamycin is a mTOR inhibitor. Combined treatment with rapamycin and PD325901 led to shrinkage of es... | MMMP | Detail |
| AZD6244 treatment decreased phospho-ERK in the tumors and significantly suppressed tumor growth. The... | MMMP | Detail |
| Akti4 is an AKT inhibitor. Suppression of the MAP kinase and PI3K/Akt pathways showed potent anti-me... | MMMP | Detail |
| Apoptosis induced by ATO is mediated by TNF | MMMP | Detail |
| Apoptosis induced by ATO is mediated by TNF | MMMP | Detail |
| Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.... | MMMP | Detail |
| Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.... | MMMP | Detail |
| 219476: CDK4 inhibitor. Investigators examined the effect of cotargeting both pathways with MEK inhi... | MMMP | Detail |
| LY294002 is a PI3K inhibitor. Multiple signaling pathways must be targeted to overcome drug resistan... | MMMP | Detail |
| LY294002 is a PI3K inhibitor. Multiple signaling pathways must be targeted to overcome drug resistan... | MMMP | Detail |
| ERK1/2 (which is activated by MEK1/2) is highly phosphorylated in melanoma metastases and protects m... | MMMP | Detail |
| MEK1/2 plays an important role in TNFalpha-resistance and is more important than NFkB, Akt, and p38M... | MMMP | Detail |
| LY294002 is a PI3K inhibitor. Both MEK and PI3K/AKT must be inhibited to restore BAD pro-apoptotic a... | MMMP | Detail |
| LY294002 is a PI3K inhibitor. Multiple signaling pathways must be targeted to overcome drug resistan... | MMMP | Detail |
| TW-37 inhibits Bcl-2, Bcl-xL and Mcl-1. This combination regimen is tumor selective through ROS/p53 ... | MMMP | Detail |
| Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO ... | MMMP | Detail |
| PD184352 is a MEK inhibitor | MMMP | Detail |
| BRAF(V600E) melanoma cells are less sensitive to apoptosis from metabolic stress (mediated by the LK... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr19:7,968,728-7,979,363
- Variant Type
- cnv
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