RRM1 UNDEREXPRESSION Detail (hg38) (RRM1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr11:4,116,039-4,160,106 View the variant detail on this assembly version. |
| hg38 | chr11:4,094,809-4,138,876 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma | Cisplatin,Gemcitabine | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 24595080 | Detail |
| pancreatic cancer | Gemcitabine | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 19543324 | Detail |
| pancreatic cancer | Gemcitabine | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 17131328 | Detail |
| lung non-small cell carcinoma | Docetaxel,Gemcitabine,Vinorelbine | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 24647522 | Detail |
| lung non-small cell carcinoma | Gemcitabine,Paclitaxel,Vinorelbine | B |
Predictive
|
Supports
|
Sensitivity/Response |
Unknown
|
3 | 23038758 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In the personalized therapy group of this study, patients received chemotherapy based on RRM-1 IHC e... | CIViC Evidence | Detail |
| There were 68 patients enrolled in this study, 28 of which were treated with gemcitabine. Of those ... | CIViC Evidence | Detail |
| In this study, human pancreatic carcinoma cell line MiaPaCa2, which is a gemcitabine-sensitive cell ... | CIViC Evidence | Detail |
| In this study, 229 tumors were analyzed for RRM1 expression. This resulted in 146 that were negative... | CIViC Evidence | Detail |
| The study began with a total of 443 patients that were randomly assigned to either regimen A (Paclit... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- RRM1
- Genome
- hg38
- Position
- chr11:4,094,809-4,138,876
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- UNDEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000300738.5
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/1257
Genome browser