chr17:7668402:> Detail (hg38) (TP53)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr17:7,571,720-7,590,856 |
| hg38 | chr17:7,668,402-7,687,538 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma | Adjuvant Chemotherapy | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 26899019 | Detail |
| cancer | Nutlin-3a | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 17671205 | Detail |
| cancer | AMGMDS3 | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 25730903 | Detail |
| leukemia | RG7112 | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 26459177 | Detail |
| colorectal cancer | Oxaliplatin,Capecitabine,Cetuximab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 24957073 | Detail |
| esophageal carcinoma | Chemotherapy | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 23515910 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Pooled analysis of TP53 mutations (exons 5-8) from 4 randomized trials (IALT, JBR10, CALGB-9633 and ... | CIViC Evidence | Detail |
| MDM2 Inhibitor Nutlin-3a induced senescence in presence of functional TP53 in murine primary fibrobl... | CIViC Evidence | Detail |
| MDM2 Inhibitor screen in a panel of 260 cancer cell lines with well characterized TP53 status shows... | CIViC Evidence | Detail |
| Phase I Trial of RG7112 in 116 heavily pretreated patients with AML, ALL, CML, CLL, sCLL demonstrate... | CIViC Evidence | Detail |
| In this retrospective biomarker analysis of the EXPERT-C trial, patients with TP53 wild-type status ... | CIViC Evidence | Detail |
| Patients with p53 wild type (as defined by low expression and/or wild-type tp53 gene) had a higher r... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr17:7,668,402-7,687,538
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- WILD TYPE
- Transcript 1 (CIViC Variant)
- ENST00000269305.4
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/369
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