Annotation Detail

Information
Associated Genes
PTGS2
Associated Variants
PTGS2 OVEREXPRESSION ( ENST00000367468.10 )
PTGS2 OVEREXPRESSION ( ENST00000367468.10 )
Associated Disease
colorectal cancer
Source Database
CIViC Evidence
Description
Mail-in surveys conducted every two years since 1980 evaluated 82,911 woman and 47,363 men for regular aspirin use. In this cohort, aspirin use was associated with a lower relative risk of colorectal cancer (RR=0.73; 95% CI 0.69-0.87; p<0.001). Immunohistochemical analysis was employed on a subset of 636 cases to evaluate COX2 overexpression. Of these tumors, 67% had moderate or strong COX2 expression and 33% had weak or absent COX-2 expression. In tumors with COX-2 overexpression, regular aspirin use conferred significant risk reduction of colorectal cancer (RR=0.64; 95%CI 0.52-0.78) however, in tumors with reduced COX2 expression, aspirin use had no influence on colorectal cancer incidence (RR=0.96, 95%CI 0.73-1.26).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1573
Gene URL
https://civic.genome.wustl.edu/links/genes/4659
Variant URL
https://civic.genome.wustl.edu/links/variants/619
Rating
3
Evidence Type
Predictive
Disease
Colorectal Cancer
Evidence Direction
Supports
Drug
Aspirin
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
17522398
Drugs
Drug NameSensitivitySupported
AspirinSensitivitytrue