Annotation Detail
Information
- Associated Genes
- TYMS
- Associated Variants
-
TYMS RS34743033
(
ENST00000323274.15 )
TYMS RS34743033 ( ENST00000323274.15 ) - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- 499 children from ALL trials treated with methotrexate were genotyped for 8 SNPs in 5 genes. The TYMS rs34743033 tandem repeat polymorphism was the only significant predictor of stomatitis in a multiple regression model considering sex, age, MRD class, WBC, MTX AUC0-48h, and genotypes as independent variables (B = −0.48; 95% CI, −0.84, −0.12; R2 = 0.018; P = .009)
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1843
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5971
- Variant URL
- https://civic.genome.wustl.edu/links/variants/779
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Methotrexate
- Evidence Level
- B
- Clinical Significance
- Adverse Response
- Pubmed
- 23652803
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Methotrexate | Adverse Response | true |