Methotrexate
Information
- Drug Name
- Methotrexate
- Description
- Entry(CIViC)
- 12
CIViC
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| 499 children from ALL trials treated with methotre... | SLCO1B1 |
SLCO1B1 p.Val174Ala (p.V174A) ( ENST00000256958.3 ) SLCO1B1 p.Val174Ala (p.V174A) ( ENST00000256958.3 ) |
Adverse Response | true | CIViC Evidence | detail |
| 499 children from ALL trials treated with methotre... | SLCO1B1 |
SLCO1B1 p.Asn130Asp (p.N130D) ( ENST00000256958.3 ) SLCO1B1 p.Asn130Asp (p.N130D) ( ENST00000256958.3 ) |
Adverse Response | true | CIViC Evidence | detail |
| 499 children from ALL trials treated with methotre... | TYMS |
TYMS RS34743033 ( ENST00000323274.15 ) TYMS RS34743033 ( ENST00000323274.15 ) |
Adverse Response | true | CIViC Evidence | detail |
| Several preclinical studies were testing drug resi... | TP53 |
TP53 p.Arg273His (p.R273H) ( ENST00000445888.6, ENST00000455263.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg273His (p.R273H) ( ENST00000504937.5, ENST00000510385.5, ENST00000445888.6, ENST00000576024.2, ENST00000604348.6, ENST00000455263.6, ENST00000504290.5, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) |
Resitance or Non-Reponse | true | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 L191F ... | PRPS1 | PRPS1 L191F PRPS1 L191F | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 S103T ... | PRPS1 | PRPS1 S103I PRPS1 S103I | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 S103N ... | PRPS1 | PRPS1 S103I PRPS1 S103I | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 K176N ... | PRPS1 | PRPS1 K176N PRPS1 K176N | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 D183E ... | PRPS1 | PRPS1 D183E PRPS1 D183E | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 A190T ... | PRPS1 | PRPS1 A190V PRPS1 A190V | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 T303S ... | PRPS1 | PRPS1 T303S PRPS1 T303S | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Lentiviral-mediated overexpression of PRPS1 N144S ... | PRPS1 | PRPS1 N144S PRPS1 N144S | Resitance or Non-Reponse | false | CIViC Evidence | detail |
| Inhibition of melanosome related protein gp100 lea... | PMEL | PMEL UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Antagonistic combinations with imexon included met... | ROS1 | ROS1 OVEREXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| Results based on both expression and forced expres... | DCT | DCT EXPRESSION | Resitance or Non-Reponse | true | MMMP | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03117751 | Active, not recruiting | Phase 2/Phase 3 | Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma | March 29, 2017 | March 31, 2028 |
| NCT05192889 | Active, not recruiting | Phase 1/Phase 2 | Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax | August 25, 2022 | July 2029 |
| NCT04214626 | Active, not recruiting | Phase 2 | R-CHOP Combined With Lenalidomide in the First-line Treatment for Patients With Diffuse Large B Cell Lymphoma | January 2, 2020 | January 2, 2025 |
| NCT02829424 | Active, not recruiting | Phase 4 | Multicenter Randomized Double Blind Controlled-study to Assess the Potential of Methotrexate Versus Placebo to Improve and Maintain Response to Anti TNF- Alpha Agents in Adult Patients With Moderate to Severe Psoriasis | January 23, 2017 | February 10, 2024 |
| NCT03792256 | Active, not recruiting | Phase 1 | Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) | April 11, 2019 | June 30, 2025 |
| NCT03020030 | Active, not recruiting | Phase 3 | Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents | March 3, 2017 | November 2034 |
| NCT01976182 | Active, not recruiting | Phase 2 | Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia | November 26, 2013 | May 26, 2027 |
| NCT02220985 | Active, not recruiting | Phase 2 | Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD | February 3, 2015 | April 1, 2025 |
| NCT02481310 | Active, not recruiting | Phase 1/Phase 2 | Combination Chemotherapy, Rituximab, and Ixazomib Citrate in Treating Patients With Non-Hodgkin Lymphoma | October 28, 2015 | July 2024 |
| NCT03710772 | Active, not recruiting | Phase 2 | Ibrutinib, Rituximab, Venetoclax, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma | May 1, 2019 | May 22, 2025 |
| NCT02143414 | Active, not recruiting | Phase 2 | Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia | June 30, 2015 | October 23, 2024 |
| NCT04909801 | Active, not recruiting | Phase 3 | A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate | September 15, 2021 | September 3, 2025 |
| NCT04169828 | Active, not recruiting | N/A | The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis | August 2, 2019 | March 1, 2025 |
| NCT03962465 | Active, not recruiting | Phase 1 | Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Patients With Relapsed/Refractory B-cell ALL | July 22, 2022 | July 2026 |
| NCT03680092 | Active, not recruiting | Phase 2 | Comparing Cyclophosphamide and Abatacept With Standard of Care Treatment Following Stem Cell Transplantation | November 26, 2019 | December 2027 |
| NCT03964090 | Active, not recruiting | Phase 2 | Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS) | June 27, 2019 | July 1, 2026 |
| NCT02427620 | Active, not recruiting | Phase 2 | Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma | June 3, 2015 | June 30, 2025 |
| NCT02828358 | Active, not recruiting | Phase 2 | Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement | April 1, 2017 | September 22, 2024 |
| NCT02329080 | Active, not recruiting | Phase 2 | New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement | December 2014 | December 2023 |
| NCT02723994 | Active, not recruiting | Phase 2 | A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia | September 30, 2016 | February 1, 2026 |
| NCT01920737 | Active, not recruiting | Phase 2 | A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia | August 2013 | August 2024 |
| NCT01856478 | Active, not recruiting | Phase 3 | LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy | May 23, 2013 | August 31, 2024 |
| NCT02883049 | Active, not recruiting | Phase 3 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations | February 29, 2012 | September 22, 2024 |
| NCT03589326 | Active, not recruiting | Phase 3 | A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia | October 4, 2018 | July 31, 2027 |
| NCT02299999 | Active, not recruiting | Phase 2 | SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer | April 7, 2014 | December 2024 |
| NCT03371667 | Active, not recruiting | Phase 3 | To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids | August 16, 2018 | December 2024 |
| NCT02710734 | Active, not recruiting | Phase 2 | Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN) | February 24, 2016 | February 2034 |
| NCT01424982 | Active, not recruiting | Phase 2 | Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia | October 5, 2011 | October 31, 2025 |
| NCT05623592 | Active, not recruiting | Phase 2 | Methotrexate as Remission Maintenance Therapy After Remission-Induction With Tocilizumab and Glucocorticoids in Giant Cell Arteritis | November 23, 2022 | November 2025 |
| NCT04293562 | Active, not recruiting | Phase 3 | A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations | July 21, 2020 | September 30, 2027 |
| NCT05918718 | Active, not recruiting | Phase 1/Phase 2 | Assessment of the Efficacy of Letrozole in the Treatment of Ectopic Pregnancy | January 20, 2023 | December 20, 2024 |
| NCT01228331 | Active, not recruiting | Phase 2/Phase 3 | Clofarabine or High-Dose Cytarabine and Pegaspargase in Children With ALL | October 2010 | December 2024 |
| NCT02277444 | Active, not recruiting | Phase 3 | A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy | December 17, 2014 | February 8, 2029 |
| NCT01190930 | Active, not recruiting | Phase 3 | Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma | August 9, 2010 | March 31, 2028 |
| NCT02114229 | Active, not recruiting | Phase 2 | Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors | May 14, 2014 | September 2027 |
| NCT03808610 | Active, not recruiting | Phase 1/Phase 2 | Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia | April 3, 2019 | December 31, 2026 |
| NCT02688140 | Active, not recruiting | Phase 3 | Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia | June 2016 | January 2025 |
| NCT02112916 | Active, not recruiting | Phase 3 | Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma | October 4, 2014 | September 22, 2024 |
| NCT01085617 | Active, not recruiting | Phase 3 | Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | December 2010 | December 2025 |
| NCT04329325 | Active, not recruiting | Phase 2 | Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia | March 30, 2020 | March 2025 |
| NCT02101853 | Active, not recruiting | Phase 3 | Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia | December 17, 2014 | September 22, 2024 |
| NCT00878254 | Active, not recruiting | Phase 2 | Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell Lymphoma | March 25, 2009 | September 2027 |
| NCT00792948 | Active, not recruiting | Phase 2 | Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia | September 1, 2009 | January 6, 2025 |
| NCT00683319 | Active, not recruiting | Observing Young Patients With Ependymoma Undergoing Standard Combination Chemotherapy | April 2008 | ||
| NCT02003222 | Active, not recruiting | Phase 3 | Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia | May 19, 2014 | December 4, 2024 |
| NCT03147612 | Active, not recruiting | Phase 2 | Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia | February 8, 2018 | February 28, 2025 |
| NCT04314193 | Active, not recruiting | Phase 4 | Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis | June 1, 2020 | July 2026 |
| NCT00557193 | Active, not recruiting | Phase 3 | Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | January 15, 2008 | June 28, 2024 |
| NCT02881086 | Active, not recruiting | Phase 3 | Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment | August 2016 | July 2025 |
| NCT00136435 | Active, not recruiting | Phase 2 | A Study in Adults With Untreated Acute Lymphoblastic Leukemia | June 2002 | July 2024 |
| NCT00544115 | Active, not recruiting | Phase 2 | Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders | October 16, 2001 | December 30, 2024 |
| NCT00476190 | Active, not recruiting | Phase 2 | ALL Adult Consortium Trial: Adult ALL Trial | April 2007 | December 2024 |
| NCT00470223 | Active, not recruiting | Phase 3 | Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma | March 2007 | December 2026 |
| NCT00408005 | Active, not recruiting | Phase 3 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma | January 22, 2007 | March 7, 2025 |
| NCT02845596 | Active, not recruiting | N/A | Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia | August 2016 | April 2024 |
| NCT00336024 | Active, not recruiting | Phase 3 | Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma | August 6, 2007 | December 31, 2028 |
| NCT00301925 | Active, not recruiting | Phase 3 | Combination Chemotherapy in Treating Patients With Early Stage Breast Cancer That Has Been Removed By Surgery | December 16, 2005 | September 2024 |
| NCT02611037 | Active, not recruiting | Phase 2 | Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural Mesothelioma | March 4, 2016 | December 2024 |
| NCT02553460 | Active, not recruiting | Phase 1/Phase 2 | Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I | January 29, 2016 | October 2031 |
| NCT02251821 | Active, not recruiting | Phase 2 | JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis | October 20, 2014 | December 28, 2025 |
| NCT05663866 | Active, not recruiting | Phase 2 | Premedication to Reduce Amivantamab Associated Infusion Related Reactions | May 18, 2023 | August 31, 2026 |
| NCT00003215 | Completed | Phase 3 | Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma | April 1997 | March 2004 |
| NCT00003217 | Completed | Phase 1 | Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia | March 1998 | September 2006 |
| NCT00003311 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma | May 20, 1998 | April 18, 2007 |
| NCT00003376 | Completed | Phase 3 | Two-Drug Combination Chemotherapy Compared With Four-Drug Combination Chemotherapy in Treating Patients With Advanced Cancer of the Urothelium | December 3, 1998 | |
| NCT00003388 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma | July 26, 1999 | |
| NCT00003436 | Completed | Phase 3 | Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia | July 1998 | December 2005 |
| NCT00003549 | Completed | Phase 2 | S9716: Combination Chemotherapy in Treating Patients With Merkel Cell Cancer | October 1998 | January 2003 |
| NCT00003577 | Completed | Phase 3 | Combination Chemotherapy With or Without Epirubicin in Treating Women With Stage I or Stage II Breast Cancer | March 1996 | September 2008 |
| NCT00003592 | Completed | Phase 3 | Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer | April 22, 1999 | March 2, 2004 |
| NCT00003593 | Completed | Phase 3 | Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome | June 1999 | April 2012 |
| NCT00003632 | Completed | Phase 2 | Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Central Nervous System Lymphoma | September 1998 | |
| NCT00003650 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma | February 1997 | November 2013 |
| NCT00003671 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia | December 1998 | February 2009 |
| NCT00003700 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia | January 1999 | January 2010 |
| NCT00003701 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Bladder Cancer | April 2, 1999 | June 15, 2007 |
| NCT00003702 | Completed | Phase 3 | Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia | June 1999 | |
| NCT00003776 | Completed | Phase 2 | Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma | December 1998 | March 2000 |
| NCT00003783 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia | March 1999 | March 2007 |
| NCT00003838 | Completed | Phase 2 | Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow | April 15, 1999 | June 18, 2020 |
| NCT00003868 | Completed | Phase 2 | Radiolabeled Monoclonal Antibody, Cyclophosphamide, and Total Body Irradiation Followed By Donor Stem Cell Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia | February 1999 | March 2005 |
| NCT00003870 | Completed | Phase 2 | Monoclonal Antibody Therapy, Cyclophosphamide, and Total-Body Irradiation Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Recurrent Acute Lymphocytic Leukemia | February 1999 | November 2001 |
| NCT00003893 | Completed | Phase 3 | Adjuvant Chemotherapy Plus Radiation Therapy in Treating Women With Early-Stage Breast Cancer | July 1998 | April 2006 |
| NCT00003934 | Completed | Phase 3 | Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia | June 1999 | |
| NCT00003937 | Completed | Phase 3 | Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma | September 1999 | June 2008 |
| NCT00004162 | Completed | Phase 1 | Liposomal Doxorubicin Plus Combination Chemotherapy in Treating Patients With AIDS-Associated Non-Hodgkin's Lymphoma | June 1997 | January 2001 |
| NCT00004228 | Completed | Phase 3 | Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma | June 2000 | March 31, 2015 |
| NCT00004231 | Completed | Phase 2 | Combination Chemotherapy, Bone Marrow or Peripheral Stem Cell Transplantation, and/or Biological Therapy in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma | October 1999 | August 2006 |
| NCT00004323 | Completed | Phase 2 | Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia | February 1995 | |
| NCT00004686 | Completed | Phase 2 | Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis | February 1994 | September 1999 |
| NCT00004748 | Completed | Phase 3 | Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis | November 1989 | |
| NCT00004784 | Completed | Phase 3 | Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis | January 1994 | |
| NCT00005086 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Stage IV Locally Advanced or Metastatic Bladder Cancer | August 1999 | April 2005 |
| NCT00005585 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia | April 2000 | |
| NCT00005596 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2000 | July 2007 |
| NCT00005603 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia | March 2000 | |
| NCT00005802 | Completed | Phase 1/Phase 2 | Chemotherapy Followed by Donor White Blood Cells Plus Interleukin-2 in Treating Patients With Acute Myeloid or Lymphocytic Leukemia | June 1999 | March 2005 |
| NCT00005854 | Completed | Phase 2 | Bone Marrow Transplantation in Treating Patients With Hematologic Cancer | December 1999 | October 2000 |
| NCT00005866 | Completed | Phase 3 | S9920 Busulfan Compared With Cyclophosphamide in Patients Undergoing Total-Body Irradiation Plus Peripheral Stem Cell Transplantation for Advanced Myelodysplastic Syndrome or Related Acute Myeloid Leukemia | February 2000 | March 2006 |
| NCT00005940 | Completed | Phase 2 | Radiolabeled BC8 Antibody, Busulfan, Cyclophosphamide Followed by Donor Stem Cell Transplant in Treating Patients With Acute Myelogenous Leukemia in First Remission | October 1999 | |
| NCT00005945 | Completed | Phase 3 | Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia | June 2000 | June 2008 |
| NCT00005977 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | September 2000 | September 2006 |
| NCT00005988 | Completed | Phase 1 | Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy | February 2000 | March 8, 2002 |
| NCT00006033 | Completed | Phase 2 | Interleukin-2 Gene or Methotrexate in Treating Patients With Recurrent or Refractory Stage III or Stage IV Head and Neck Cancer | June 2000 | June 2004 |
| NCT00006168 | Completed | Phase 3 | Ursodiol-Methotrexate for Primary Biliary Cirrhosis | January 1994 | March 2004 |
| NCT00006184 | Completed | Phase 2 | Chemotherapy, Stem Cell Transplantation and Donor and Patient Vaccination for Treatment of Multiple Myeloma | February 8, 2001 | January 12, 2008 |
| NCT00006258 | Completed | Phase 2 | Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma | November 1997 | January 2005 |
| NCT00006455 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma (ALCL 99) | November 26, 1999 | September 3, 2020 |
| NCT00006747 | Completed | Phase 2 | Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma | November 2000 | February 2003 |
| NCT00008151 | Completed | Phase 2 | Gemtuzumab Ozogamicin, Fludarabine, and Total-body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome | October 2000 | July 2002 |
| NCT00012051 | Completed | Phase 3 | Chemotherapy and Peripheral Stem Cell Transplant With or Without Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma | September 2000 | October 2007 |
| NCT00014274 | Completed | Phase 2/Phase 3 | Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium | January 2001 | |
| NCT00014469 | Completed | Phase 2 | Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Advanced Hematologic Cancer | December 2000 | May 2007 |
| NCT00015873 | Completed | Phase 3 | Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia | May 1999 | December 2009 |
| NCT00016302 | Completed | N/A | Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2001 | |
| NCT00018954 | Completed | Phase 2 | Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma | October 1992 | October 2002 |
| NCT00020943 | Completed | Phase 2 | Chemotherapy and Rituximab With Peripheral Stem Cell Transplantation in Treating Patients With Mantle Cell Lymphoma | June 2001 | September 2009 |
| NCT00022126 | Completed | Phase 2 | Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia | November 2002 | April 2006 |
| NCT00022516 | Completed | Phase 3 | Low-dose Oral Cyclophosphamide and Methotrexate Maintenance for Hormone Receptor-negative Early Breast Cancer | November 2000 | August 2016 |
| NCT00022737 | Completed | Phase 3 | Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia | October 2002 | |
| NCT00023998 | Completed | Phase 2 | Chemotherapy With or Without Trastuzumab in Treating Patients With Metastatic Osteosarcoma | July 2001 | May 2007 |
| NCT00024050 | Completed | Phase 2 | Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Myelodysplastic Syndrome | February 2001 | August 2007 |
| NCT00025545 | Completed | Phase 2 | Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia</p> | March 1996 | October 2002 |
| NCT00027547 | Completed | Phase 1/Phase 2 | Combination Chemotherapy and Total-Body Irradiation Followed by Peripheral Stem Cell or Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia | July 2001 | July 2004 |
| NCT00027573 | Completed | Phase 2 | Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic or Unresectable Kidney Cancer | October 2001 | June 2006 |
| NCT00027924 | Completed | Phase 2 | Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia or Myelodysplastic Syndrome | October 2001 | May 2003 |
| NCT00028600 | Completed | Phase 2 | Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma | November 2001 | February 2010 |
| NCT00028756 | Completed | Phase 3 | Comparison of Immediate and Delayed Adjuvant Chemotherapy in Treating Patients Who Have Undergone a Radical Cystectomy for Stage III or Stage IV Transitional Cell Carcinoma of the Bladder Urothelium | October 2001 | July 2014 |
| NCT00030264 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas | February 2001 | March 2016 |
| NCT00035074 | Completed | N/A | A Pharmacokinetic Study to Determine the Oral Bioavailability of Methotrexate in Patients With Inflammatory Bowel Disease | ||
| NCT00036153 | Completed | Phase 3 | Study to Assess Efficacy of Tacrolimus + Methotrexate Versus Placebo + Methotrexate in Treatment of Rheumatoid Arthritis | March 2002 | January 2004 |
| NCT00036868 | Completed | Phase 2 | Combination Chemotherapy With Trastuzumab in Treating Women With Metastatic Breast Cancer | February 2002 | February 2010 |
| NCT00037102 | Completed | Phase 4 | Combination Therapy With Avonex and BiMonthly High Dose Intravenous Methotrexate in Multiple Sclerosis | July 2001 | December 2003 |
| NCT00038610 | Completed | Phase 2 | Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia | March 2001 | July 2014 |
| NCT00039130 | Completed | Phase 2 | Rituximab, Chemotherapy, and Filgrastim in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia | May 2002 | October 2014 |
| NCT00039377 | Completed | Phase 2 | Chemotherapy, Imatinib Mesylate, and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2002 | February 2014 |
| NCT00040690 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia | November 2008 | December 2008 |
| NCT00041132 | Completed | Phase 2 | S0213 Chemotherapy Plus Rituximab in Treating Patients With Mantle Cell Lymphoma | September 2002 | June 2011 |
| NCT00045305 | Completed | Phase 2 | Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes | October 24, 2006 | September 2014 |
| NCT00045539 | Completed | Phase 2 | Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma | October 2002 | January 2006 |
| NCT00048568 | Completed | Phase 3 | A Phase III Study of Abatacept (BMS-188667) in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate | December 2002 | October 2009 |
| NCT00049569 | Completed | N/A | Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia | January 2003 | |
| NCT00049634 | Completed | Phase 1/Phase 2 | Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Myeloproliferative Disorder | January 2002 | |
| NCT00051311 | Completed | Phase 2 | Modified Stem Cell Transplant Procedure to Treat Patients With Blood and Immune System Cancers | January 3, 2003 | September 25, 2014 |
| NCT00053196 | Completed | Phase 2 | Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer | December 2002 | August 2010 |
| NCT00054340 | Completed | Phase 1/Phase 2 | Combination Chemotherapy and Antithymocyte Globulin in Reducing Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplantation For Myelodysplastic Syndrome or Myeloproliferative Disorder | October 2002 | September 2006 |
| NCT00057811 | Completed | Phase 2 | Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma | June 2004 | July 2014 |
| NCT00059839 | Completed | Phase 3 | Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma | November 2003 | July 2014 |
| NCT00061945 | Completed | Phase 1/Phase 2 | Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia | June 2003 | October 2012 |
| NCT00068250 | Completed | Phase 1/Phase 2 | Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma | July 2003 | December 2016 |
| NCT00070135 | Completed | Phase 2 | Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission | January 2004 | June 15, 2016 |
| NCT00070174 | Completed | Phase 2 | Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy | December 2003 | December 2013 |
| NCT00074178 | Completed | Phase 2 | Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma | January 2000 | July 2006 |
| NCT00074191 | Completed | Phase 2 | Methotrexate, Procarbazine, Lomustine, Dexamethasone, and Cytarabine in Treating Patients With Primary CNS Lymphoma | January 2000 | October 2000 |
| NCT00074438 | Completed | Phase 2 | Study to Assess the Efficacy and Safety of Rituximab in Patients With Rheumatoid Arthritis | June 2003 | July 2011 |
| NCT00075725 | Completed | Phase 3 | Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia | December 29, 2003 | March 31, 2021 |
| NCT00082797 | Completed | Phase 2 | High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | July 12, 2005 | |
| NCT00083031 | Completed | Phase 2 | Metronomic Low-Dose Cyclophosphamide and Methotrexate With or Without Bevacizumab in Treating Women With Metastatic Breast Cancer | July 2003 | August 2009 |
| NCT00084838 | Completed | Phase 2 | Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT | February 2003 | March 2013 |
| NCT00089037 | Completed | Phase 1/Phase 2 | Sirolimus, Tacrolimus, and Methotrexate in Preventing Acute Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation | June 2003 | April 2005 |
| NCT00089349 | Completed | Phase 2 | Alemtuzumab With or Without Methotrexate and Mercaptopurine in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia | July 2004 | |
| NCT00096135 | Completed | N/A | Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes | November 2004 | |
| NCT00098774 | Completed | Phase 2 | Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Primary CNS Lymphoma | October 2004 | September 2014 |
| NCT00098839 | Completed | Phase 1/Phase 2 | Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL) | February 2005 | April 2011 |
| NCT00103285 | Completed | Phase 3 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 11, 2005 | March 31, 2021 |
| NCT00106522 | Completed | Phase 3 | A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis Currently on Methotrexate Therapy | May 2005 | November 2007 |
| NCT00106535 | Completed | Phase 3 | A Study to Assess the Effect of Tocilizumab + Methotrexate on Prevention of Structural Joint Damage in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA) | January 2005 | July 2012 |
| NCT00106548 | Completed | Phase 3 | A Study to Assess the Effect of Tocilizumab + Methotrexate on Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis | October 2007 | |
| NCT00109408 | Completed | Phase 3 | A Study to Assess the Safety and Efficacy of Tocilizumab in Patients With Active Rheumatoid Arthritis | July 2005 | December 2007 |
| NCT00109837 | Completed | Phase 2 | S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | April 2005 | November 2014 |
| NCT00112034 | Completed | Phase 4 | AVONEX® Combination Trial - "ACT" | June 2003 | May 2007 |
| NCT00112645 | Completed | Phase 1 | Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors | April 2005 | February 2011 |
| NCT00119301 | Completed | Phase 1 | Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma | April 2005 | |
| NCT00121134 | Completed | N/A | Bevacizumab With or Without Cyclophosphamide and Methotrexate: A Pilot Study in Women With Operable Breast Cancer | June 2005 | May 2011 |
| NCT00122382 | Completed | Phase 3 | Remission and Joint Damage Progression in Early Rheumatoid Arthritis | July 2005 | February 2009 |
| NCT00124111 | Completed | Phase 2 | A Study of Cyclophosphamide/Methotrexate/5-Fluorouracil (CMF) With Pegfilgrastim in Subjects With Breast Cancer | ||
| NCT00130195 | Completed | Phase 2 | Study of Imatinib-Combined Chemotherapy for BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) | September 2002 | May 2008 |
| NCT00132899 | Completed | Phase 3 | COMMIT (Combination Of Maintenance Methotrexate-Infliximab Trial) | December 2005 | July 2008 |
| NCT00133991 | Completed | Phase 2 | Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Leukemia | July 2005 | August 2013 |
| NCT00134030 | Completed | Phase 3 | Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma | November 14, 2005 | September 30, 2022 |
| NCT00146614 | Completed | Phase 2 | Tacrolimus, Sirolimus and Methotrexate as Graft Versus Host Disease Prophylaxis After Blood Stem Cell Transplantation | July 2002 | April 2003 |
| NCT00153530 | Completed | Phase 4 | Whole Brain Irradiation in Primary Central Nervous System (CNS) Lymphoma (PCNSL) | May 2000 | May 2009 |
| NCT00154336 | Completed | Phase 2 | A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis. | July 2004 | August 2005 |
| NCT00161655 | Completed | Phase 4 | Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis | April 2005 | December 2006 |
| NCT00165178 | Completed | Phase 3 | Treatment of Acute Lymphoblastic Leukemia in Children | September 2000 | May 2011 |
| NCT00176462 | Completed | Phase 2 | CINJALL: Treatment for Children With Acute Lymphocytic Leukemia | February 2001 | September 2008 |
| NCT00187122 | Completed | N/A | Treatment for Patients With Stage III or IV Non-Hodgkin Lymphoma | March 1993 | June 2004 |
| NCT00189488 | Completed | Phase 2 | Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation | December 2005 | August 2013 |
| NCT00193011 | Completed | Phase 3 | Weekly Docetaxel and CMF in the Adjuvant Treatment of Elderly Women With High-Risk Breast Cancer | March 2002 | August 2004 |
| NCT00194272 | Completed | Phase 3 | Two-Dose Methotrexate for Ectopic Pregnancy | March 2001 | June 2007 |
| NCT00194779 | Completed | Phase 2 | Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery | October 2003 | June 2011 |
| NCT00195494 | Completed | Phase 4 | Study Comparing Etanercept and Methotrexate vs. Methotrexate Alone in Rheumatoid Arthritis | November 2004 | March 2008 |
| NCT00195663 | Completed | Phase 3 | Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid Arthritis | December 2000 | April 2012 |
| NCT00198978 | Completed | Phase 4 | German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | January 2003 | June 2014 |
| NCT00198991 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) | April 2003 | June 30, 2013 |
| NCT00199004 | Completed | Phase 4 | Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab | April 2004 | March 2009 |
| NCT00199017 | Completed | Phase 4 | German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults | April 2004 | |
| NCT00199056 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) | October 1999 | December 2005 |
| NCT00199069 | Completed | Phase 4 | German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) | April 1993 | May 2001 |
| NCT00199082 | Completed | Phase 4 | Newly Diagnosed Mature B-ALL, Burkitt's Lymphoma and Other High-grade Lymphoma in Adults | July 2002 | June 2010 |
| NCT00199095 | Completed | Phase 4 | Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia | February 1997 | June 2003 |
| NCT00206219 | Completed | Phase 3 | Head and Neck Phase III Iressa Versus Methotrexate Refractory: Iressa Versus Methotrexate (IMEX) | November 2003 | September 2007 |
| NCT00209859 | Completed | Phase 4 | Methotrexate and Cyclosporine in Treatment of Early Rheumatoid Arthritis | October 1998 | November 2007 |
| NCT00215046 | Completed | Phase 2 | Vinblastine and Methotrexate in Children With Pulmonary Vein Stenosis | March 2000 | October 2006 |
| NCT00234845 | Completed | Phase 3 | Adalimumab in Combination With Methotrexate vs Methotrexate Alone in Early Rheumatoid Arthritis | March 2003 | |
| NCT00234936 | Completed | Phase 3 | Quality of Life Study With Adalimumab in Rheumatoid Arthritis | December 2003 | |
| NCT00235859 | Completed | Phase 3 | Adalimumab Administered in Korean Rheumatoid Arthritis Subjects Treated With Methotrexate | July 2003 | |
| NCT00241189 | Completed | Phase 1/Phase 2 | Rapamycin vs Methotrexate in Diffuse SSc | August 2002 | June 2006 |
| NCT00243412 | Completed | Phase 2 | A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate | August 2005 | February 2009 |
| NCT00245037 | Completed | Phase 1/Phase 2 | Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer | June 2005 | August 2015 |
| NCT00251641 | Completed | Phase 3 | The Effects of Infliximab Versus Methotrexate in the Treatment of Moderate to Severe Psoriasis (Study P04271AM2)(COMPLETED) | September 1, 2005 | June 1, 2008 |
| NCT00252668 | Completed | Phase 4 | Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects | June 2004 | September 2005 |
| NCT00259610 | Completed | Phase 4 | Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) | May 2004 | June 2009 |
| NCT00264550 | Completed | Phase 3 | An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy | December 2005 | May 2012 |
| NCT00266227 | Completed | Phase 3 | A Study of Retreatment With Rituximab in Patients With Rheumatoid Arthritis Receiving Background Methotrexate | January 2006 | |
| NCT00267865 | Completed | Phase 2 | Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma | September 14, 2006 | September 19, 2019 |
| NCT00268528 | Completed | Study to Assess Compliance With Long-Term Mercaptopurine Treatment in Young Patients With Acute Lymphoblastic Leukemia in Remission | May 30, 2005 | June 30, 2020 | |
| NCT00276601 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Acute Promyelocytic Leukemia | October 2004 | June 2013 |
| NCT00276757 | Completed | N/A | Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis | April 2001 | June 2013 |
| NCT00281983 | Completed | Phase 1/Phase 2 | Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia | June 2000 | July 2010 |
| NCT00282308 | Completed | Phase 2 | A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate | January 23, 2006 | May 28, 2012 |
| NCT00283985 | Completed | Phase 2 | Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma | February 2006 | June 2012 |
| NCT00290433 | Completed | Phase 2 | Efficacy of the HCVIDDOXIL Regimen in Patients With Newly Diagnosed Peripheral T-Cell Lymphoma | September 2003 | July 2015 |
| NCT00290498 | Completed | Phase 2 | Study of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or Younger | August 1, 2005 | August 11, 2017 |
| NCT00296023 | Completed | N/A | Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer | January 1999 | June 2008 |
| NCT00299104 | Completed | Phase 3 | A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis | January 2006 | July 2013 |
| NCT00299130 | Completed | Phase 3 | A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid Arthritis | October 2005 | July 2013 |
| NCT00299182 | Completed | Phase 1/Phase 2 | Study of AMG 531 to Evaluate the Safety & Efficacy in Patients With Non-Hodgkin's Lymphoma | March 2006 | April 2012 |
| NCT00301834 | Completed | Phase 2 | Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders | January 2005 | September 2011 |
| NCT06426979 | Completed | N/A | Sequential Letrozole and Methotrexate Therapy Role in Treatment of Tubal Ectopic Pregnancy | January 1, 2023 | January 1, 2024 |
| NCT00000395 | Completed | Phase 2 | Antifolate Effectiveness in Arthritis | September 1996 | August 2002 |
| NCT00000658 | Completed | Phase 3 | A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma | February 1996 | |
| NCT00000689 | Completed | Phase 1 | Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma | March 1991 | |
| NCT00000703 | Completed | N/A | Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members | March 1990 | |
| NCT00000834 | Completed | Phase 1 | A Phase I Study of Methotrexate for HIV Infection | June 2002 | |
| NCT00001498 | Completed | Phase 2 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | February 1996 | December 2000 |
| NCT00001677 | Completed | Phase 2 | Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and Efficacy | June 1998 | April 2000 |
| NCT00002456 | Completed | Phase 3 | Graft-Versus-Host Disease Prevention in Treating Patients Who Are Undergoing Bone Marrow Transplantation | May 1986 | April 2002 |
| NCT00002463 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors | February 1989 | January 2008 |
| NCT00002471 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | February 1990 | January 2003 |
| NCT00002476 | Completed | Phase 3 | Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer | January 1990 | January 2010 |
| NCT00002489 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors | October 1991 | June 2002 |
| NCT00002494 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia | May 1992 | January 2006 |
| NCT00002514 | Completed | Phase 3 | Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission | May 7, 1993 | |
| NCT00002524 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma | June 1993 | October 2005 |
| NCT00002542 | Completed | Phase 3 | Tamoxifen in Treating Women With High-Risk Breast Cancer | July 20, 1993 | January 11, 2011 |
| NCT00002547 | Completed | Phase 2 | Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome | August 1987 | October 2003 |
| NCT00002552 | Completed | Phase 2 | Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma | October 1993 | October 2003 |
| NCT00002554 | Completed | Phase 2 | Monoclonal Antibody Followed by Bone Marrow Transplantation in Treating Patients With Acute Myelogenous Leukemia in Remission or First Relapse | November 1993 | December 1999 |
| NCT00002571 | Completed | Phase 2 | SWOG-9320 Combination Chemotherapy, Radiation Therapy, and Antiviral Therapy in Treating Patients With AIDS-Related Lymphoma | June 1994 | July 2011 |
| NCT00002578 | Completed | Phase 2 | Gallium Nitrate in Treating Patients With AIDS-Related Non-Hodgkin's Lymphoma | August 1994 | |
| NCT00002579 | Completed | Phase 3 | Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer | March 1993 | |
| NCT00002580 | Completed | Phase 3 | Tamoxifen, Ovarian Ablation, and/or Combination Chemotherapy in Treating Premenopausal Women With Stage I, Stage II, or Stage IIIA Invasive Breast Cancer | June 1993 | |
| NCT00002581 | Completed | Phase 3 | Tamoxifen With or Without Combination Chemotherapy in Treating Postmenopausal Women With Operable Invasive Breast Cancer | June 1993 | |
| NCT00002582 | Completed | Phase 3 | Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer | June 1993 | April 2007 |
| NCT00002590 | Completed | Phase 2 | Combination Chemotherapy in Treating Children With Lymphoma | July 1994 | March 2007 |
| NCT00002598 | Completed | Phase 2 | Combination Chemotherapy and Interferon Alfa in Treating Patients With Chronic Myelogenous Leukemia | June 1994 | June 2004 |
| NCT00002618 | Completed | Phase 3 | Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma | December 1994 | September 2006 |
| NCT00002657 | Completed | Phase 2 | SWOG-9239 Reduction of Immunosuppression Plus Interferon Alfa and Combination Chemotherapy in Treating Patients With Malignant Tumors That Develop After Organ Transplant | May 1995 | July 2011 |
| NCT00002665 | Completed | Phase 2 | SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia | July 1995 | December 2003 |
| NCT00002676 | Completed | Phase 2 | Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma | July 1995 | October 2006 |
| NCT00002691 | Completed | Phase 2 | Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma | August 1995 | June 2000 |
| NCT00002700 | Completed | Phase 3 | Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia | August 1995 | |
| NCT00002704 | Completed | Phase 2 | Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia | January 1996 | |
| NCT00002744 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | May 1996 | March 2007 |
| NCT00002755 | Completed | Phase 3 | Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer | November 1995 | June 1999 |
| NCT00002756 | Completed | Phase 2 | Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia | June 1996 | March 2012 |
| NCT00002757 | Completed | Phase 3 | TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma | June 2001 | October 2009 |
| NCT00002766 | Completed | Phase 3 | Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma | March 1996 | September 2011 |
| NCT00002768 | Completed | Phase 2 | Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Acute Myeloid Leukemia in Second Remission | June 1996 | March 2009 |
| NCT00002784 | Completed | Phase 3 | High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Combination Chemotherapy in Treating Women With High-Risk Breast Cancer | June 1996 | December 2011 |
| NCT00002785 | Completed | Phase 2 | Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia | July 1996 | March 2007 |
| NCT00002789 | Completed | Phase 3 | Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myeloid Leukemia | May 1996 | September 2001 |
| NCT00002792 | Completed | Phase 2 | Combination Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloproliferative Disorders | June 1996 | April 2003 |
| NCT00002798 | Completed | Phase 3 | Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome | August 1996 | |
| NCT00002805 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome | August 1997 | June 2008 |
| NCT00002809 | Completed | Phase 2 | Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer | August 1996 | December 2003 |
| NCT00002812 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia | September 1996 | |
| NCT00002816 | Completed | Phase 3 | Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia | December 1996 | April 2006 |
| NCT00002831 | Completed | Phase 1/Phase 2 | Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia | August 1, 1995 | December 31, 2002 |
| NCT00002835 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Lymphoma | October 30, 1995 | February 4, 2004 |
| NCT00002865 | Completed | Phase 2 | High-Intensity, Brief-Duration Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia | April 1995 | August 2001 |
| NCT00002919 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Stage II Bladder Cancer | November 1996 | January 2003 |
| NCT00002970 | Completed | Phase 2 | 506U78 in Treating Patients With Refractory Hematologic Cancer | June 1997 | |
| NCT00003012 | Completed | Phase 3 | Combination Chemotherapy Following Surgery in Treating Women With Early Stage Breast Cancer | October 1996 | |
| NCT00003013 | Completed | Phase 3 | Chemotherapy Plus Surgery in Treating Women With Breast Cancer | October 1996 | March 2009 |
| NCT00003019 | Completed | Phase 2 | Vinblastine and Methotrexate in Treating Children With Desmoid Tumors | August 1997 | September 2006 |
| NCT00003061 | Completed | Phase 2 | Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Primary CNS Lymphoma | July 1997 | |
| NCT00003187 | Completed | Phase 2/Phase 3 | Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma | May 1995 | February 2005 |
| NCT00003209 | Completed | Phase 3 | Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer | December 1997 | |
| NCT00344253 | Completed | Phase 3 | Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis | March 2006 | January 2012 |
| NCT00346359 | Completed | Phase 2 | Fludarabine and Busulfan Followed by Donor Peripheral Stem Cell Transplant and Antithymocyte Globulin, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Cancer | March 2006 | November 2007 |
| NCT00354393 | Completed | Phase 2 | Combination Chemotherapy With or Without Surgery & Chemoradiotherapy in Patients With Malignant Pleural Mesothelioma | August 2002 | June 2009 |
| NCT00357084 | Completed | Phase 2 | Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant | May 2006 | |
| NCT00361335 | Completed | Phase 3 | A Study of Safety and Effectiveness of Golimumab in Participants With Active Rheumatoid Arthritis Despite Methotrexate Therapy | September 2006 | September 2009 |
| NCT00365001 | Completed | Phase 1 | A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis. | April 2008 | |
| NCT00368654 | Completed | Phase 1/Phase 2 | Evaluate Whether Combination Therapy With Methotrexate and Raptiva in Psoriasis Patients is Safe and Increases Efficacy | January 2007 | May 2008 |
| NCT00369226 | Completed | Phase 1/Phase 2 | Bortezomib Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease (GVHD) After Mismatched Allogeneic Non-Myeloablative Blood Stem Cell Transplantation | August 2006 | September 2011 |
| NCT00372619 | Completed | Phase 1/Phase 2 | Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia | March 2007 | August 2012 |
| NCT00381680 | Completed | Phase 3 | Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia | March 2007 | |
| NCT00382109 | Completed | Phase 3 | Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission | March 2007 | June 30, 2017 |
| NCT00385788 | Completed | Phase 2 | Allogeneic Blood Stem Cell Transplantation and Adoptive Immunotherapy for Hodgkin's Disease | July 2005 | August 2016 |
| NCT00390793 | Completed | Phase 2 | Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. | September 28, 2006 | February 2, 2024 |
| NCT00392834 | Completed | Phase 2 | Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma | September 2006 | July 2013 |
| NCT00396747 | Completed | Phase 4 | A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study | June 2003 | September 2005 |
| NCT00400946 | Completed | Phase 3 | Treatment of Acute Lymphoblastic Leukemia in Children | April 2005 | June 2019 |
| NCT00402558 | Completed | Phase 1 | Alloreactive NK Cells for Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) | May 2006 | April 2014 |
| NCT00405275 | Completed | N/A | Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy | July 2007 | May 2012 |
| NCT00406393 | Completed | Phase 3 | Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402) | November 2006 | October 2015 |
| NCT00409838 | Completed | Phase 3 | A Phase III Study of Abatacept in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate | April 2007 | December 2011 |
| NCT00416819 | Completed | N/A | Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Primary CNS Lymphoma | September 2003 | February 2012 |
| NCT00420927 | Completed | Phase 4 | Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis | December 2006 | July 2010 |
| NCT00424502 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker. | January 2007 | October 2009 |
| NCT00430118 | Completed | Phase 3 | Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia | July 2000 | January 2012 |
| NCT00439283 | Completed | Phase 3 | Study of Two Schedules of Infliximab Maintenance Therapy in Ankylosing Spondylitis | April 2003 | December 2004 |
| NCT00439556 | Completed | Phase 2 | Bortezomib and Chemotherapy in Treating Participants With Lymphoid Malignancies Undergoing Stem Cell Transplant | February 13, 2007 | June 7, 2018 |
| NCT00440726 | Completed | Phase 1/Phase 2 | Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) | August 4, 2006 | February 26, 2011 |
| NCT00441961 | Completed | N/A | Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis | October 2006 | June 2011 |
| NCT00443430 | Completed | Phase 4 | Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis | May 2007 | October 2010 |
| NCT00445744 | Completed | N/A | Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome | December 2006 | June 2013 |
| NCT00445770 | Completed | Phase 3 | Study Evaluating the Efficacy and Safety of Etanercept and Methotrexate in Japanese Subjects With Rheumatoid Arthritis | July 2006 | July 2010 |
| NCT00446784 | Completed | Phase 1 | Study Of The Safety Of CE 224,545 And Methotrexate In Patients With Rheumatoid Arthritis | April 2007 | August 2007 |
| NCT00448201 | Completed | Phase 2 | Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease | January 7, 2011 | May 23, 2012 |
| NCT00448357 | Completed | Phase 1/Phase 2 | Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen | October 2005 | November 2015 |
| NCT00450801 | Completed | Phase 2 | R-MACLO-IVAM and Thalidomide in Untreated Mantle Cell Lymphoma | April 2004 | July 2015 |
| NCT00458250 | Completed | Phase 1 | Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H | September 2006 | February 2008 |
| NCT00458848 | Completed | Phase 2 | Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia | October 2004 | March 2014 |
| NCT00462345 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies. | June 2007 | July 2009 |
| NCT00463008 | Completed | N/A | Pharmacologic Study of Methotrexate in Patients Undergoing Stereotactic Biopsy for Recurrent High-Grade Glioma | May 2004 | April 2007 |
| NCT00468546 | Completed | Phase 3 | A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy | May 2003 | July 2012 |
| NCT00477412 | Completed | Phase 1/Phase 2 | Bortezomib, Rituximab and Combination Chemotherapy in Treating Participants With Mantle Cell Lymphoma | April 3, 2007 | October 28, 2020 |
| NCT00482833 | Completed | Phase 3 | Phase III Trial in Acute Promyelocytic Leukemia Patients | August 2007 | October 17, 2019 |
| NCT00489203 | Completed | Phase 2 | Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer | April 2007 | |
| NCT00492856 | Completed | Phase 3 | S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic Leukemia | June 1, 2007 | May 4, 2016 |
| NCT00494897 | Completed | Phase 4 | PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia | June 1996 | December 2007 |
| NCT00496665 | Completed | Phase 1 | ZD6474 (Zactima) and Metronomic Chemotherapy in Advanced Breast Cancer | July 2007 | March 2009 |
| NCT00498589 | Completed | Phase 2 | Comparison of Methotrexate vs Placebo in Corticosteroid-dependent Ulcerative Colitis | September 2007 | June 2014 |
| NCT00502853 | Completed | Phase 4 | A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. | October 25, 2007 | July 23, 2010 |
| NCT00502996 | Completed | Phase 3 | A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid Arthritis. | February 2006 | December 2008 |
| NCT00504777 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Agents. | July 2007 | March 2010 |
| NCT00506155 | Completed | Phase 2 | Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial Cancer | June 2007 | August 2014 |
| NCT00506922 | Completed | Phase 1/Phase 2 | Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT | September 2000 | November 2009 |
| NCT00513474 | Completed | Phase 1 | Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant | January 2008 | February 12, 2013 |
| NCT00513981 | Completed | Phase 1 | High-Dose Methotrexate in Treating Young Patients With Solid Tumors | March 2007 | August 2009 |
| NCT00521430 | Completed | N/A | Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease | April 2004 | September 2008 |
| NCT00526175 | Completed | Phase 4 | LAL-BR/2001: Study Treatment to Low Risk ALL | June 2001 | December 2015 |
| NCT00526409 | Completed | Phase 4 | LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia | June 2005 | October 2014 |
| NCT00535782 | Completed | Phase 3 | A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis | October 31, 2007 | January 31, 2011 |
| NCT00536978 | Completed | Phase 2 | Natural Killer (NK) Cell Adback After Allogeneic Stem Cell Transplant With Campath-IH Plus Chemorx for Patients With Lymphoid Malignancies | September 2007 | November 2010 |
| NCT00551460 | Completed | Phase 2 | S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia | November 15, 2007 | February 5, 2018 |
| NCT00553202 | Completed | Phase 2 | Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia | January 2008 | March 31, 2020 |
| NCT00565409 | Completed | Phase 4 | Study Comparing Etanercept in Combination With Methotrexate in Subjects With Rheumatoid Arthritis | March 2008 | May 2011 |
| NCT00574496 | Completed | Phase 2 | Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin Lymphoma | November 13, 2007 | August 2, 2022 |
| NCT00576433 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor. | December 2007 | November 2010 |
| NCT00578305 | Completed | Phase 3 | A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate | November 2007 | May 2013 |
| NCT00579644 | Completed | Phase 3 | Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone | March 28, 2001 | May 31, 2006 |
| NCT00586846 | Completed | Phase 2 | Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed Osteosarcoma | July 2003 | February 2009 |
| NCT00587873 | Completed | Phase 2 | Sequential Administration of Oral 6-Thioguanine (6-TG) After Methotrexate (MTX) in Patients With Relapsed Hodgkin's Disease (Phase II) | March 1994 | June 2009 |
| NCT00588536 | Completed | Phase 2 | Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCH | January 1995 | June 2009 |
| NCT00589563 | Completed | Phase 2 | Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer | May 2007 | February 2012 |
| NCT00612274 | Completed | Early Phase 1 | Sirolimus, Tacrolimus and Short Course Methotrexate for Prevention of Acute GVHD in Recipients of Mismatched Unrelated Donor Allogeneic Stem Cell Transplantation | October 2007 | October 2014 |
| NCT00613457 | Completed | Phase 3 | Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia | September 2000 | July 2006 |
| NCT00618501 | Completed | Phase 2 | Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | October 2005 | January 2009 |
| NCT00627666 | Completed | Phase 2 | Donor Stem Cell Transplant After Busulfan, Fludarabine, and Antithymocyte Globulin in Treating Patients With Hematological Cancer | January 2003 | June 2010 |
| NCT00636909 | Completed | Phase 2 | Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorders | July 1999 | |
| NCT00642460 | Completed | Phase 3 | A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA) | May 2008 | August 2014 |
| NCT00645632 | Completed | N/A | Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma | November 1990 | January 2008 |
| NCT00651040 | Completed | Phase 3 | Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM | May 2008 | November 2014 |
| NCT00653068 | Completed | Phase 3 | Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System | February 10, 2009 | March 31, 2024 |
| NCT00654368 | Completed | Phase 4 | CAMEO: Canadian Methotrexate and Etanercept Outcome Study | June 2008 | February 2013 |
| NCT00659412 | Completed | Phase 2 | A Placebo-controlled Study With an Extension Examining the Safety and Efficacy of Alefacept in Psoriatic Arthritis | September 2003 | March 2005 |
| NCT00667342 | Completed | Phase 2 | A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma | June 3, 2008 | August 2017 |
| NCT00669877 | Completed | Phase 2 | Rituximab and Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) for Burkitt's and Burkitt's -Like Leukemia/Lymphoma | August 2002 | October 2015 |
| NCT00671034 | Completed | Phase 3 | Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia | July 21, 2008 | March 31, 2021 |
| NCT00679731 | Completed | Phase 3 | A Study of Safety and Efficacy Comparing ABT-874 Versus Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis | April 2008 | November 2009 |
| NCT00695188 | Completed | Phase 4 | Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis | May 2008 | December 2010 |
| NCT00701129 | Completed | Phase 4 | An Exploratory Study of the Safety and Efficacy of Prophylactic Immunomodulatory Treatment in Myozyme-naive Cross-Reacting Immunologic Material (CRIM[-]) Patients With Infantile-Onset Pompe Disease | October 2009 | March 2013 |
| NCT00707083 | Completed | Phase 3 | Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia | May 1, 2008 | March 1, 2020 |
| NCT00718718 | Completed | Phase 2 | A Study of Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy | August 11, 2008 | March 3, 2011 |
| NCT00720109 | Completed | Phase 2/Phase 3 | Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | July 14, 2008 | March 31, 2020 |
| NCT00727831 | Completed | Phase 1/Phase 2 | Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | July 2008 | July 2011 |
| NCT00741455 | Completed | N/A | Chemotherapy Followed by Allogeneic Stem Cell Transplantation for Hematologic Malignancies | June 2004 | May 1, 2020 |
| NCT00742924 | Completed | Phase 1 | Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma | August 2008 | |
| NCT00754572 | Completed | Phase 3 | A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis | February 2009 | October 2012 |
| NCT00759811 | Completed | Phase 2/Phase 3 | METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial) | December 2007 | November 2008 |
| NCT00760864 | Completed | Phase 2 | Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis | August 2004 | September 2005 |
| NCT00760968 | Completed | Phase 2 | Efficacy and Safety of TAK-783 in Subjects With Rheumatoid Arthritis | August 2007 | February 2009 |
| NCT00767325 | Completed | Phase 3 | A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography | December 2008 | October 2011 |
| NCT00783510 | Completed | Juvenile Idiopathic Arthritis (JIA) Registry | July 11, 2008 | February 1, 2024 | |
| NCT00787761 | Completed | Phase 2 | Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer | April 2007 | May 2012 |
| NCT00791531 | Completed | Phase 1 | Assessment of Safety and Pharmacokinetics of a Low Dose of Methotrexate in Healthy Adult Male Kenyan Volunteers | March 2009 | August 2009 |
| NCT00808509 | Completed | Phase 4 | A Pilot Study of the Feasibility of Discontinuation of Adalimumab in Stable Rheumatoid Arthritis Patients in Clinical Remission | January 2009 | September 2012 |
| NCT00808639 | Completed | Phase 2 | Dose-Dense MVAC With Pegfilgrastim Support in Subjects With Muscle-Invasive Urothelial Carcinoma | December 2008 | September 2016 |
| NCT00809172 | Completed | Phase 3 | Study of Methotrexate Efficacy Versus Cyclosporine in Moderate to Severe Atopic Dermatitis Patients | December 2008 | April 2012 |
| NCT00810199 | Completed | Phase 3 | A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment | March 2009 | January 2013 |
| NCT00814138 | Completed | Phase 2 | Efficacy of Methotrexate in Myasthenia Gravis | April 2009 | January 2014 |
| NCT00847886 | Completed | Phase 1 | Study of LX3305 and Methotrexate in Subjects With Stable Rheumatoid Arthritis | February 2009 | March 2009 |
| NCT00851318 | Completed | Phase 3 | Long-term Treatment Study of Certolizumab Pegol (CDP870) as Add-on Medication to Methotrexate in Japanese Rheumatoid Arthritis (RA) Patients | March 2009 | June 2013 |
| NCT00857389 | Completed | Phase 2 | Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies | March 2, 2009 | March 9, 2019 |
| NCT00860574 | Completed | Phase 2 | Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia | February 2009 | |
| NCT00866307 | Completed | Phase 1 | Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011) | February 23, 2009 | March 31, 2021 |
| NCT00866749 | Completed | Phase 2 | Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma | September 12, 2006 | July 26, 2018 |
| NCT00866918 | Completed | Phase 3 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia | March 9, 2009 | September 30, 2022 |
| NCT00873093 | Completed | Phase 2 | Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | March 2009 | September 2014 |
| NCT00880815 | Completed | Phase 1 | Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant | February 17, 2009 | May 28, 2019 |
| NCT00896168 | Completed | Phase 4 | An Efficacy and Safety Study of Infliximab in Participants With Rheumatoid Arthritis | June 2007 | April 2008 |
| NCT00901550 | Completed | N/A | The Chinese University of Hong Kong Early Arthritis Study | November 2008 | October 2011 |
| NCT00905034 | Completed | Phase 2 | Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) Salvage | March 2009 | February 2015 |
| NCT00919503 | Completed | Phase 2 | Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders | July 31, 2009 | June 10, 2020 |
| NCT00928018 | Completed | Phase 3 | Tacrolimus/Sirolimus/Methotrexate vs Tacrolimus/Methotrexate or Cyclosporine/Mycophenolate Mofetil for GVHD Prophylaxis After Reduced Intensity Allogeneic Stem Cell Transplantation for Patients With Lymphoma | June 2009 | November 2014 |
| NCT00932113 | Completed | Phase 4 | Mechanism of Action Study for Psoriasis | June 2009 | May 1, 2017 |
| NCT00934648 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Methotrexate | October 2007 | November 2010 |
| NCT00950989 | Completed | Phase 2 | Brodalumab (AMG 827) in Rheumatoid Arthritis (RA) Participants With Inadequate Response to Methotrexate | December 30, 2009 | February 11, 2011 |
| NCT00959036 | Completed | Phase 1/Phase 2 | Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis | September 2009 | January 2011 |
| NCT00965653 | Completed | Phase 1 | A Study of Subcutaneously Administered Tocilizumab in Patients With Rheumatoid Arthritis | August 2009 | July 2011 |
| NCT00967057 | Completed | Phase 3 | Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia | October 2002 | December 2011 |
| NCT00968253 | Completed | Phase 1/Phase 2 | RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia | November 2009 | December 2015 |
| NCT00973752 | Completed | Phase 2 | Treatment of Older Adults With Acute Lymphoblastic Leukemia | August 2009 | April 2016 |
| NCT00989703 | Completed | Phase 1 | GLPG0259 Multiple Ascending Dose and Methotrexate Drug-drug Interaction (DDI) in Healthy Subjects | September 2009 | January 2010 |
| NCT00992602 | Completed | Phase 2 | Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer | April 2011 | October 2014 |
| NCT00993135 | Completed | Kidney Dysfunction in Children and Young Adults Who Have Received Methotrexate for Acute Lymphoblastic Leukemia | December 2008 | ||
| NCT00993317 | Completed | Phase 3 | A Study of CDP870 as Add-on Meditation to Methotrexate (MTX) in Patients With Rheumatoid Arthritis | October 2009 | August 2011 |
| NCT01000610 | Completed | Phase 4 | A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate | March 17, 2008 | May 16, 2012 |
| NCT01001208 | Completed | Phase 3 | The Efficacy and Safety of Adding Methotrexate to Etanercept in Psoriasis | November 2009 | February 2011 |
| NCT01007435 | Completed | Phase 3 | A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis | October 31, 2009 | January 28, 2014 |
| NCT01009242 | Completed | Phase 1/Phase 2 | To Evaluate the Blood Levels and Safety of IV and Subcutaneous CDP6038 in Subjects With Rheumatoid Arthritis Using Methotrexate | October 2009 | September 2010 |
| NCT01010581 | Completed | Phase 2 | SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis | November 2009 | July 2011 |
| NCT01011920 | Completed | Phase 2 | Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma | November 2009 | March 2017 |
| NCT01020734 | Completed | Phase 2 | Donor Stem Cell Transplant or Bone Marrow Transplant in Treating Patients With Acute Myeloid Leukemia in Remission | May 2011 | July 2015 |
| NCT01027000 | Completed | Phase 2 | Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | February 2010 | April 2023 |
| NCT01034137 | Completed | Phase 3 | A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid Arthritis | January 2010 | September 2014 |
| NCT01056614 | Completed | Phase 2 | Fludarabine Phosphate, Busulfan, and Anti-Thymocyte Globulin Followed By Donor Peripheral Blood Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Myeloid Malignancies | September 2004 | April 2016 |
| NCT01059773 | Completed | Phase 4 | A Safety and Efficacy Study of Ustekinumab in Patients With Plaque Psoriasis Who Have Had an Inadequate Response to Methotrexate | October 2009 | August 2011 |
| NCT01061736 | Completed | Phase 2/Phase 3 | Evaluation of Sarilumab (SAR153191/REGN88) on Top of Methotrexate in Rheumatoid Arthritis Patients | March 2010 | October 2013 |
| NCT01063062 | Completed | Phase 3 | A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE) | February 28, 2010 | January 17, 2011 |
| NCT01079988 | Completed | Phase 4 | Study of Therapeutic Options for Subjects Discontinuing Efalizumab and Experiencing Disease Recurrence | February 2004 | April 2005 |
| NCT01104025 | Completed | Phase 2 | Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis | April 2010 | April 2016 |
| NCT01117441 | Completed | Phase 3 | International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia | June 2010 | December 31, 2021 |
| NCT01123265 | Completed | National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study | June 2010 | June 2014 | |
| NCT01142726 | Completed | Phase 3 | Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis | December 2010 | October 2014 |
| NCT01156883 | Completed | N/A | Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia | April 2010 | October 31, 2017 |
| NCT01162421 | Completed | Phase 4 | A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis | September 2010 | July 2015 |
| NCT01163747 | Completed | Phase 4 | A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA) | September 2010 | June 2012 |
| NCT01168219 | Completed | Phase 2 | Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia | July 15, 2010 | February 1, 2020 |
| NCT01172639 | Completed | Phase 4 | Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis. | February 2009 | June 2015 |
| NCT01177371 | Completed | Phase 2 | High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma | March 1988 | February 2010 |
| NCT01181271 | Completed | Phase 2 | Tandem Auto-Allo Transplant for Lymphoma | August 2010 | February 2016 |
| NCT01185288 | Completed | Phase 4 | A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) | September 2010 | January 2013 |
| NCT01185301 | Completed | Phase 3 | Study to Determine the Effects of Different Doses of Methotrexate (MTX) When Taken With Adalimumab in Subjects With Early Rheumatoid Arthritis (RA) | October 2010 | September 2012 |
| NCT01185353 | Completed | Phase 2 | A Study in Participants With Rheumatoid Arthritis on Background Methotrexate Therapy | October 2010 | March 2014 |
| NCT01187264 | Completed | Phase 4 | Dose Ranging Study to Compare the Efficacy and Safety of Methotrexate in Plaque Type Psoriasis | August 2008 | September 2009 |
| NCT01188798 | Completed | Phase 3 | Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies | September 2010 | February 2012 |
| NCT01225393 | Completed | Phase 2 | A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid Arthritis | November 2010 | |
| NCT01225874 | Completed | N/A | Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALL | December 1999 | |
| NCT01230983 | Completed | Phase 3 | Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma | June 1996 | October 2004 |
| NCT01232920 | Completed | Phase 3 | First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot Trial | October 2010 | June 2012 |
| NCT01235507 | Completed | Phase 3 | A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER) | February 2011 | December 2012 |
| NCT01245452 | Completed | N/A | Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or Methotrexate | May 2010 | June 2013 |
| NCT01251614 | Completed | Phase 3 | A Double Blind Study in Pediatric Subjects With Chronic Plaque Psoriasis, Studying Adalimumab vs. Methotrexate | December 2010 | February 2015 |
| NCT01256398 | Completed | Phase 2 | Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | December 14, 2010 | November 15, 2021 |
| NCT01308255 | Completed | Phase 4 | Infliximab as Induction Therapy in Early Rheumatoid Arthritis (IDEA) | September 2006 | February 2011 |
| NCT01313858 | Completed | A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554) | April 2010 | September 2015 | |
| NCT01319981 | Completed | Phase 2 | Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia | March 5, 2013 | November 11, 2020 |
| NCT01323920 | Completed | Phase 2 | Bortezomib-based GVHD Prophylaxis After Allogeneic Transplant for Patients Without Matched Related Donors | May 2011 | November 2013 |
| NCT01338987 | Completed | Phase 2 | Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation | April 19, 2011 | November 19, 2020 |
| NCT01345682 | Completed | Phase 3 | LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy | January 5, 2012 | December 6, 2016 |
| NCT01353859 | Completed | Phase 3 | A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs | March 2011 | July 2012 |
| NCT01358253 | Completed | Phase 4 | Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia | December 2010 | December 2012 |
| NCT01363128 | Completed | Phase 2 | Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | July 12, 2011 | April 8, 2020 |
| NCT01373151 | Completed | Phase 2 | Phase IIB Rheumatoid Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to Methotrexate | June 2011 | June 2015 |
| NCT01379209 | Completed | Phase 1/Phase 2 | Intravenous Administration of RGI-2001 in Patient Undergoing Allogenic Hematopoietic Stem Cell Transplantation (AHSCT) | September 2011 | April 2017 |
| NCT01382940 | Completed | Phase 4 | A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis | July 26, 2011 | January 6, 2013 |
| NCT01390402 | Completed | Phase 2 | Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG | January 2012 | November 2014 |
| NCT01393405 | Completed | Phase 2 | Methotrexate in Induction and Maintenance of Steroid Free Remission in Ulcerative Colitis | February 2012 | April 2017 |
| NCT01399372 | Completed | Phase 2 | Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma | September 2011 | May 20, 2022 |
| NCT01399697 | Completed | Phase 4 | A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate | September 2011 | May 2014 |
| NCT01403415 | Completed | Phase 1 | Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma | September 2011 | |
| NCT01404429 | Completed | Phase 4 | Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis | May 2011 | July 2012 |
| NCT01411267 | Completed | Phase 1 | AC220 for Children With Relapsed/Refractory ALL or AML | September 1, 2011 | September 12, 2013 |
| NCT01412879 | Completed | Phase 2 | S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma | November 2011 | March 2021 |
| NCT01432145 | Completed | Phase 2 | A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective Tumours | May 2011 | May 2015 |
| NCT01451515 | Completed | Phase 2 | NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma | May 25, 2012 | May 31, 2022 |
| NCT01469013 | Completed | Phase 2 | Oral Baricitinib (LY3009104)Treatment in Japanese Participants With Active Rheumatoid Arthritis on Background Methotrexate Therapy | November 2011 | December 2013 |
| NCT01471444 | Completed | Phase 3 | Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) | November 2, 2011 | December 14, 2020 |
| NCT01481272 | Completed | Phase 2 | Ofatumumab With IVAC Salvage Chemotherapy in Diffuse Large B Cell Lymphoma Patients | November 2011 | December 2018 |
| NCT01490723 | Completed | Phase 2 | Zevalin-Containing Nonmyeloablative Conditioning for Stem Cell Transplantation (SCT) | January 2013 | April 24, 2019 |
| NCT01491958 | Completed | Phase 2 | Safety & Efficacy of Atorvastatin for Prophylaxis of Acute Graft Versus Host Disease in Patients With Hematological Malignancies HLA- Donor Hematopoietic Stem Cell Transplantation | December 10, 2011 | June 27, 2016 |
| NCT01519791 | Completed | Phase 3 | A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid Arthritis | January 2012 | September 2015 |
| NCT01527149 | Completed | Phase 2 | Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma | December 6, 2011 | January 11, 2024 |
| NCT01528163 | Completed | Phase 2 | Study Comparing Two Treatments in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | February 2012 | November 2014 |
| NCT01529827 | Completed | Phase 2 | Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies | February 28, 2012 | August 29, 2019 |
| NCT01535053 | Completed | Phase 3 | Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia | June 18, 2012 | July 17, 2020 |
| NCT01554696 | Completed | Phase 2 | A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to Methotrexate | July 6, 2012 | February 11, 2014 |
| NCT01558089 | Completed | Good EULAR Response In Patients With Early Rheumatoid Arthritis | March 2013 | May 2015 | |
| NCT01572662 | Completed | Phase 2 | Allogeneic Transplantation Using Timed Sequential Busulfan and Fludarabine Conditioning | April 11, 2012 | August 11, 2022 |
| NCT01578499 | Completed | Phase 3 | A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Participants With CD30-Positive Cutaneous T-Cell Lymphoma (ALCANZA Study) | June 11, 2012 | July 6, 2018 |
| NCT01587989 | Completed | Phase 3 | A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to Methotrexate | February 2012 | February 2014 |
| NCT01594333 | Completed | Phase 3 | Cardiovascular Inflammation Reduction Trial | April 2013 | October 30, 2019 |
| NCT01613079 | Completed | Phase 2/Phase 3 | Efficacy and Safety of Tripterygium Wilfordii in Patients With Rheumatoid Arthritis | May 2012 | June 2013 |
| NCT01614197 | Completed | Phase 1 | A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma | July 3, 2015 | September 4, 2020 |
| NCT01619176 | Completed | N/A | Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood | October 2012 | December 2014 |
| NCT01654575 | Completed | N/A | Methotrexate in Symptomatic Knee Osteoarthritis | July 2011 | January 2012 |
| NCT01664910 | Completed | Phase 1/Phase 2 | CMC-544 and Allogeneic Transplantation for CD22 Positive-Lymphoid Malignancies | October 29, 2012 | June 28, 2023 |
| NCT01700946 | Completed | Phase 2 | Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma | April 15, 2013 | July 24, 2021 |
| NCT01709578 | Completed | Phase 3 | To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET) | October 2012 | March 2015 |
| NCT01710358 | Completed | Phase 3 | A Study in Moderate to Severe Rheumatoid Arthritis | October 2012 | September 2015 |
| NCT01711359 | Completed | Phase 3 | A Study in Participants With Moderate to Severe Rheumatoid Arthritis | November 2012 | August 2015 |
| NCT01737671 | Completed | Early Phase 1 | Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study | December 27, 2012 | January 11, 2018 |
| NCT01754389 | Completed | Phase 2 | Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell Transplant | January 2013 | November 2016 |
| NCT01754805 | Completed | Phase 1 | A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis | January 22, 2010 | March 25, 2010 |
| NCT01758198 | Completed | Phase 4 | Abatacept Post-marketing Clinical Study in Japan | April 11, 2013 | December 26, 2016 |
| NCT01760226 | Completed | Early Phase 1 | Dose Adjusted EPOCH-R, to Treat Mature B Cell Malignancies | January 2013 | December 2016 |
| NCT01768572 | Completed | Phase 3 | To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN) | March 2013 | October 2014 |
| NCT01769209 | Completed | Phase 2 | Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia | March 2013 | July 4, 2017 |
| NCT01788501 | Completed | Phase 2/Phase 3 | Tacrolimus/Methotrexate Versus Cyclosporine/Methotrexate for Prophylaxis of Graft Versus Host Disease | November 2011 | March 1, 2017 |
| NCT01789255 | Completed | Phase 2 | Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies | June 2013 | March 2014 |
| NCT01790568 | Completed | Phase 2 | Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell Transplant | December 2014 | October 31, 2017 |
| NCT01791153 | Completed | Phase 3 | An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) | July 22, 2013 | June 4, 2018 |
| NCT01812954 | Completed | Economic Evaluation of Systemic Treatments for Moderate-to-severe Psoriasis | March 2013 | June 2014 | |
| NCT01829295 | Completed | Phase 3 | Methotrexate and Mycophenolate Mofetil for UVEITIS | August 2013 | August 9, 2018 |
| NCT01850680 | Completed | Phase 1 | Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid Arthritis | April 2013 | December 2013 |
| NCT01858740 | Completed | Phase 2 | Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children | April 10, 2014 | July 30, 2023 |
| NCT01870128 | Completed | Phase 3 | Comparison of Three Different Treatment Regimes in Early Rheumatoid Arthritis: A Randomized Open-labelled Trial | August 2009 | June 2011 |
| NCT01871649 | Completed | Phase 3 | Initial Treatment With Golimumab in Early PsA | August 2013 | November 2018 |
| NCT01876004 | Completed | Phase 4 | Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy | September 2011 | June 2013 |
| NCT01884623 | Completed | Phase 3 | Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer | November 6, 2013 | October 12, 2021 |
| NCT01884636 | Completed | Phase 1 | A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Methotrexate | February 2013 | March 2013 |
| NCT01895764 | Completed | Phase 4 | Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) | March 2013 | April 2015 |
| NCT01900431 | Completed | Phase 2 | Phase II Study to Analyze Sarilumab in Non-Infectious Uveitis | October 2013 | April 2016 |
| NCT01941095 | Completed | Phase 3 | A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis | November 20, 2013 | July 10, 2016 |
| NCT01951885 | Completed | Phase 3 | Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention | July 7, 2014 | August 11, 2021 |
| NCT01976364 | Completed | Phase 3 | Open-Label Extension Study Of Tofacitinib In Psoriatic Arthritis | February 17, 2014 | May 20, 2019 |
| NCT01979536 | Completed | Phase 2 | Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma | November 13, 2013 | March 31, 2024 |
| NCT01984099 | Completed | Phase 3 | RCT on the Efficacy of Methotrexate for the Prevention of GTD | December 2011 | August 2013 |
| NCT01987479 | Completed | Phase 3 | A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid Arthritis | January 30, 2014 | May 26, 2016 |
| NCT01995201 | Completed | Phase 3 | A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid Arthritis | September 2013 | March 2016 |
| NCT02001987 | Completed | Phase 3 | A Study of Tocilizumab (RoActemra) in Tocilizumab-Naive Participants With Rheumatoid Arthritis and Inadequate Response to Non-Biologic Disease-Modifying Antirheumatic Drugs (DMARDs) and/or Biologic Therapy | January 2014 | December 2015 |
| NCT02006706 | Completed | Phase 3 | A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD Therapy | August 10, 2006 | November 23, 2007 |
| NCT02017964 | Completed | Phase 2 | Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic Medulloblastoma | December 24, 2013 | December 31, 2022 |
| NCT02029599 | Completed | Phase 2 | The Efficacy and Safety of Fang yi Qing Feng Shi Granules in Subjects With Rheumatoid Arthritis | March 2014 | |
| NCT02037191 | Completed | Phase 3 | The Efficiency Of The Methotrexate At Patients Affected By Grave Pelade | February 2014 | December 2017 |
| NCT02046603 | Completed | Phase 3 | A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent | March 4, 2014 | August 4, 2016 |
| NCT02046616 | Completed | Phase 3 | A Study of Subcutaneous (SC) Tocilizumab (RoActemra/Actemra) in Participants With Active Rheumatoid Arthritis (RA) and Inadequate Response to Disease-Modifying Anti-Rheumatic Drugs (DMARDs) | May 28, 2014 | September 13, 2016 |
| NCT02057250 | Completed | Phase 3 | To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis | March 2014 | March 2016 |
| NCT02065713 | Completed | Phase 3 | Efficacy of Golimumab in Combination With Methotrexate (MTX) Versus MTX Monotherapy, in Improving Dactylitis, in MTX naïve Psoriatic Arthritis Patients | August 2014 | June 2017 |
| NCT02074319 | Completed | Phase 1 | RCT of Methotrexate Added to Treatment As Usual in Schizophrenia | December 2013 | August 2015 |
| NCT02076659 | Completed | Phase 1 | Combination Therapy of F8IL10 and Methotrexate in Rheumatoid Arthritis Patients | September 2011 | April 13, 2017 |
| NCT02076997 | Completed | N/A | Individualized High Dose Methotrexate to Treat Cancer in Children Who Have a Significant Risk for Side Effects to Methotrexate | January 1, 2014 | May 10, 2019 |
| NCT02093026 | Completed | Phase 2 | Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA) | August 2002 | December 2012 |
| NCT02097173 | Completed | Phase 1 | Bioavailability in Patient With Psoriasis: Metoject Prefilled Pen | May 2013 | |
| NCT02097745 | Completed | Phase 3 | A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies | June 2004 | June 2013 |
| NCT02105636 | Completed | Phase 3 | Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141) | May 29, 2014 | September 10, 2021 |
| NCT02115204 | Completed | Phase 3 | 4 x Epirubicin, Cyclophosphamide, Followed by 4 x Docetaxel Versus 6 x CMF / 6 x CEF | June 2000 | August 2010 |
| NCT02122081 | Completed | Phase 1 | Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies | July 27, 2015 | September 6, 2022 |
| NCT02129582 | Completed | Phase 1 | Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies | November 5, 2014 | March 5, 2020 |
| NCT02151851 | Completed | Phase 3 | A Study of Certolizumab Pegol as Additional Therapy in Chinese Patients With Active Rheumatoid Arthritis | July 2014 | June 2016 |
| NCT02152696 | Completed | Phase 3 | Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location | July 25, 2014 | August 19, 2019 |
| NCT02177071 | Completed | Phase 4 | A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy | October 9, 2015 | October 2021 |
| NCT02177695 | Completed | Phase 2 | S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer | August 28, 2014 | December 1, 2022 |
| NCT02196701 | Completed | Phase 3 | Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR Study | August 5, 2014 | March 17, 2017 |
| NCT02206035 | Completed | Phase 2 | A Study of Tacrolimus/Methotrexate and Tocilizumab to Prevent Acute Graft-Versus-Host Disease (AGVD) After Allogeneic Hematopoietic Stem Cell Transplant | December 2014 | September 2018 |
| NCT02228772 | Completed | Phase 1 | Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults | December 2014 | November 2019 |
| NCT02252042 | Completed | Phase 3 | Pembrolizumab (MK-3475) Versus Standard Treatment for Recurrent or Metastatic Head and Neck Cancer (MK-3475-040/KEYNOTE-040) | November 17, 2014 | August 15, 2022 |
| NCT02269358 | Completed | Phase 4 | Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation | July 2015 | October 9, 2018 |
| NCT02280694 | Completed | Phase 2 | Low Dose Metronomic Poly-chemotherapy for Metastatic CRC | January 2015 | December 2019 |
| NCT02293109 | Completed | Phase 1 | Carfilzomib and Hyper-CVAD in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoma | December 17, 2015 | January 11, 2018 |
| NCT02293902 | Completed | Phase 3 | A Study Assessing the Efficacy and Safety of Sarilumab Added to MTX in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis (SARIL-RA-KAKEHASI) | November 2014 | October 2016 |
| NCT02305849 | Completed | Phase 3 | A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment | July 25, 2014 | November 28, 2017 |
| NCT02309359 | Completed | Phase 2 | A Dose-Range Finding Study for ALX-0061 Combination Therapy in Subjects With Rheumatoid Arthritis | January 2015 | August 2016 |
| NCT02328755 | Completed | Phase 1/Phase 2 | Peginterferon Alfa-2a to Enhance Anti-leukemic Responses After Allogeneic Transplantation in Acute Myeloid Leukemia | January 2015 | March 25, 2019 |
| NCT02330380 | Completed | Comparative Effectiveness of Psoriasis Treatments on Systemic Inflammation | April 2013 | December 2016 | |
| NCT02339441 | Completed | Treatment Outcome in Early Diffuse Cutaneous Systemic Sclerosis | June 2010 | March 2016 | |
| NCT02345850 | Completed | Phase 3 | Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301) | August 2015 | October 5, 2020 |
| NCT02347332 | Completed | Phase 3 | Phase III Study of Vinflunine Plus Methotrexate Versus Methotrexate Alone in Patients With Head and Neck Cancer | April 25, 2014 | November 23, 2018 |
| NCT02366091 | Completed | Phase 2 | Inflammation and Coronary Endothelial Function | January 2015 | September 1, 2020 |
| NCT02373579 | Completed | Phase 2 | Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia | June 2012 | October 2014 |
| NCT02374021 | Completed | Phase 4 | Treatments Against RA and Effect on FDG-PET/CT | July 2016 | May 2021 |
| NCT02376790 | Completed | Phase 3 | Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis | March 3, 2015 | July 6, 2018 |
| NCT02379091 | Completed | Phase 2 | Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA) | December 17, 2014 | December 5, 2016 |
| NCT02383901 | Completed | A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX | September 2014 | May 2016 | |
| NCT02385110 | Completed | Phase 2 | Alemtuzumab or Tocilizumab in Combination With Etoposide and Dexamethasone for the Treatment of Adult Patients With Hemophagocytic Lymphohistiocytosis | September 23, 2015 | January 24, 2023 |
| NCT02389400 | Completed | Phase 2 | Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis | January 2014 | September 2017 |
| NCT02393859 | Completed | Phase 3 | Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL) | November 10, 2015 | November 21, 2022 |
| NCT02412670 | Completed | Phase 2 | Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer | August 27, 2015 | May 10, 2022 |
| NCT02433184 | Completed | Phase 4 | Very Early Versus Delayed Etanercept in Patients With RA | July 2011 | July 2019 |
| NCT02451748 | Completed | Phase 4 | IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA | August 2015 | December 2017 |
| NCT02458339 | Completed | Phase 1 | Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors | June 15, 2015 | March 1, 2019 |
| NCT02480946 | Completed | Phase 1 | Safety and Tolerability Study of MBS2320 in Healthy Subjects and Subjects With Rheumatoid Arthritis | July 2015 | March 2017 |
| NCT02487069 | Completed | N/A | Allo-HSCT With Alternative Donor in Treatment of Hematologic Malignancy | June 2015 | February 29, 2020 |
| NCT02504268 | Completed | Phase 3 | Effects of Abatacept in Patients With Early Rheumatoid Arthritis | September 3, 2015 | March 19, 2020 |
| NCT02504359 | Completed | Phase 1 | Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma | July 20, 2015 | September 9, 2020 |
| NCT02523976 | Completed | Phase 2 | Dasatinib Combined With Chemotherapy in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia | August 1, 2015 | December 31, 2021 |
| NCT02553018 | Completed | Phase 3 | Comparison of Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated by Methotrexate Either by Auto-injector or by Conventional Sub-cutaneous Syringe | September 2015 | August 2017 |
| NCT02557100 | Completed | Phase 4 | Study to Assess Changes in the Immune Profile in Adults With Early Rheumatoid Arthritis | November 19, 2015 | March 28, 2019 |
| NCT02608112 | Completed | Study to Describe Real World Drug Retention Rate of the Tocilizumab at One Year | December 31, 2015 | July 26, 2018 | |
| NCT02634801 | Completed | Phase 3 | A Study of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque Psoriasis Naive to Systemic Treatment | January 20, 2016 | November 14, 2017 |
| NCT02638948 | Completed | Phase 2 | Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid Arthritis | February 16, 2016 | May 3, 2018 |
| NCT02644499 | Completed | Phase 4 | Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis | December 31, 2015 | September 15, 2017 |
| NCT02655705 | Completed | Phase 4 | Comparison Study of Psoriasis Severity Assessment Tools | August 2014 | March 2016 |
| NCT02660684 | Completed | Phase 4 | Study to Assess the Safety and Efficacy of Tacrolimus (Prograf Capsule/Injection) and Methotrexate (MTX) Combination Therapy for Prevention of Graft Versus Host Disease (GVHD) in Patients Who Received Peripheral Hematopoietic Stem Cell Transplantation From a Sibling Donor | February 2008 | February 2010 |
| NCT02663622 | Completed | Phase 2 | Phase II Trial of Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft-Versus-Host Disease (GVHD) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-002) | September 19, 2016 | May 18, 2021 |
| NCT02677181 | Completed | Phase 4 | Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT | January 2016 | April 2022 |
| NCT02693210 | Completed | Phase 2 | A Study to Evaluate the Efficacy and Safety of Mabthera Alone and in Combination With Either Cyclophosphamide or Methotrexate in Patients With Rheumatoid Arthritis | February 2001 | August 2004 |
| NCT02699710 | Completed | Phase 1 | Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects | September 3, 2015 | May 26, 2016 |
| NCT02706873 | Completed | Phase 3 | A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate | February 23, 2016 | November 10, 2022 |
| NCT02706951 | Completed | Phase 3 | A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY) | March 23, 2016 | August 10, 2022 |
| NCT02714998 | Completed | N/A | The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy | January 2013 | February 2015 |
| NCT02744196 | Completed | Phase 3 | Clinical Trial to Evaluate Efficacy and Safety of Acellbia® (JSC "BIOCAD") With Methotrexate in First Line Biological Therapy of Patients With Active Rheumatoid Arthritis | January 2015 | August 2017 |
| NCT02748785 | Completed | Phase 4 | MTX Discontinuation and Vaccine Response | September 2015 | August 2016 |
| NCT02762838 | Completed | Phase 3 | Comparative Clinical Trial of Efficacy and Safety of BCD-055 and Remicade® in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis | January 2016 | July 2018 |
| NCT02764762 | Completed | Phase 4 | Triple Combination Therapy in High Risk Crohn's Disease (CD) | April 18, 2017 | July 5, 2022 |
| NCT02766465 | Completed | Phase 2 | Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503) | November 2016 | May 2, 2023 |
| NCT02772965 | Completed | Phase 3 | Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy | October 2016 | April 7, 2022 |
| NCT02779283 | Completed | Phase 1 | Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia | January 13, 2016 | September 20, 2018 |
| NCT02825147 | Completed | Phase 2 | Pegaspargase and Methotrexate Based Regimens for Newly Diagnosed Extranodal NK/T Cell Lymphoma | September 2013 | July 2017 |
| NCT02831855 | Completed | Phase 4 | Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid Arthritis | September 1, 2016 | December 17, 2018 |
| NCT02867800 | Completed | Phase 1 | Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease | July 2016 | December 30, 2023 |
| NCT02884635 | Completed | Phase 2 | A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking Methotrexate | September 16, 2016 | October 25, 2017 |
| NCT02885181 | Completed | Phase 2 | Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With Methotrexate | September 21, 2016 | September 20, 2017 |
| NCT02902861 | Completed | Phase 3 | Trial in Patients With Psoriasis Treated With Methotrexate Using an Optimized Treatment Schedule (METOP) | February 2013 | May 2015 |
| NCT02916979 | Completed | Phase 1 | Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG | September 6, 2016 | February 11, 2022 |
| NCT03028467 | Completed | Phase 1/Phase 2 | Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid Arthritis | January 24, 2017 | December 20, 2017 |
| NCT03058471 | Completed | N/A | Efficacy of Starting Methotrexate Early in Chikungunya Arthritis | December 2016 | May 2018 |
| NCT03131973 | Completed | Phase 1 | Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin | May 13, 2017 | November 10, 2017 |
| NCT03148860 | Completed | Phase 3 | Impact of Concomitant MTX on Efficacy, Safety and Adherence of Ustekinumab-treatment in Patients With Active PsA | December 15, 2016 | October 21, 2021 |
| NCT03163966 | Completed | Phase 2 | A Study of the EP4 Antagonist CR6086 in Combination With Methotrexate, in DMARD-naïve Patients With Early Rheumatoid Arthritis | October 5, 2017 | January 8, 2019 |
| NCT03172325 | Completed | Phase 3 | Study to Demonstrate Non-Inferior Efficacy and Safety of CinnoRA® Versus Humira® for Treatment of Active RA | November 18, 2015 | January 4, 2017 |
| NCT03217734 | Completed | Phase 2/Phase 3 | MAP Study: Methotrexate and Adalimumab in Psoriasis | April 10, 2017 | December 31, 2018 |
| NCT03219437 | Completed | Phase 3 | A Study Comparing the Safety and Efficacy of Risankizumab to Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis | July 30, 2018 | November 26, 2021 |
| NCT03244462 | Completed | Phase 1 | Food Effect, Oral & Intravenous Pharmacokinetics and Absolute Bioavailability of BAY1834845 Including Drug-drug Interaction With Methotrexate | August 18, 2017 | July 20, 2018 |
| NCT03327116 | Completed | N/A | Effect of Methotrexate on Inflammatory Response in Adult Atopic Dermatitis Patients | November 1, 2017 | December 1, 2018 |
| NCT03332719 | Completed | Phase 3 | Efficacy, Safety and Immunogenicity of Enerceptan Compared to Enbrel in Rheumatoid Arthritis | February 2016 | September 2017 |
| NCT03349281 | Completed | Phase 1 | Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL | March 25, 2019 | October 12, 2022 |
| NCT03384654 | Completed | Phase 2 | A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | May 14, 2018 | September 27, 2022 |
| NCT03402087 | Completed | Phase 1 | A Study to Investigate BMS-986165 and Methotrexate in Healthy Male Patients | January 8, 2018 | March 25, 2018 |
| NCT03449758 | Completed | Phase 4 | Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis | March 5, 2018 | July 31, 2019 |
| NCT03492658 | Completed | Phase 4 | Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA) | May 17, 2018 | April 6, 2022 |
| NCT03518242 | Completed | Phase 1 | Molecular Profile of Breast Cancer in Ugandan Patients With Stage IIB-III Breast Cancer | June 6, 2018 | May 4, 2022 |
| NCT03520842 | Completed | Phase 2 | Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer | August 14, 2018 | June 15, 2022 |
| NCT03589833 | Completed | Phase 4 | Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RA | May 14, 2019 | July 27, 2022 |
| NCT03699631 | Completed | Phase 2 | PROACTIVE: Preventing Acute/Chronic GVHD With TocIlizumab Combined With GVHD Prophylaxis Post allogEneic Transplant | November 6, 2018 | April 1, 2023 |
| NCT03737708 | Completed | Phase 4 | A Study Comparing Biologics + Methotrexate With Biologics + Tacrolimus in Patients With Rheumatoid Arthritis (RA) | February 13, 2019 | June 16, 2020 |
| NCT03757364 | Completed | Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis | January 7, 2018 | September 30, 2018 | |
| NCT03797872 | Completed | Phase 4 | Psoriatic Oligoarthritis Intervention With Symptomatic thErapy | April 17, 2019 | July 16, 2020 |
| NCT03813147 | Completed | Phase 1 | Pevonedistat, Azacitidine, Fludarabine Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome | May 17, 2019 | December 31, 2023 |
| NCT03813199 | Completed | Phase 2 | Study of Two Doses of ABX464 in Participants With Moderate to Severe Rheumatoid Arthritis | July 4, 2019 | April 27, 2021 |
| NCT03815448 | Completed | N/A | Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis | July 18, 2019 | December 1, 2023 |
| NCT03959241 | Completed | Phase 3 | TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801) | June 25, 2019 | September 19, 2022 |
| NCT03965728 | Completed | Phase 1 | Study to Investigate Safety, Tolerability, Pharmacokinetics, and Drug-drug Interaction of Multiple Oral Doses of BAY1830839 in Healthy Male Participants | June 5, 2019 | May 11, 2022 |
| NCT03994731 | Completed | Phase 4 | Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout | June 13, 2019 | April 11, 2022 |
| NCT04038970 | Completed | Phase 2 | Efficacy and Safety Study of KN019 in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate | November 8, 2019 | July 28, 2022 |
| NCT04108468 | Completed | Phase 3 | GOLimumab and Methotrexate Versus Methotrexate in Very Early PsA (GOLMEPsA) | October 27, 2015 | July 2023 |
| NCT04154852 | Completed | Phase 2 | ADalimumab in Persistent Early Oligoarthrits Study (ADEOS) | June 2011 | January 16, 2017 |
| NCT04157010 | Completed | Phase 4 | Tocilizumab REMission in Early RA | May 2013 | March 29, 2016 |
| NCT04192617 | Completed | Phase 2 | A Study to Evaluate the Safety and Efficacy of SM03 in Patients With Rheumatoid Arthritis Receiving Methotrexate | December 31, 2014 | February 3, 2016 |
| NCT04247815 | Completed | Phase 2 | Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe RA | March 16, 2020 | February 4, 2021 |
| NCT04268394 | Completed | Phase 1 | A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677 | March 13, 2020 | June 2, 2021 |
| NCT04360785 | Completed | N/A | Effect of Two Methotrexate in Sync With the First Adalimumab to Prevent the Immunisation Anti Ada in Spondyloarthritis | November 11, 2020 | February 27, 2023 |
| NCT04571697 | Completed | A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha Therapy | September 28, 2020 | October 27, 2020 | |
| NCT04691505 | Completed | Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs Hydroxychloroquine | December 23, 2020 | August 31, 2021 | |
| NCT04752163 | Completed | Phase 1/Phase 2 | DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia | March 25, 2021 | November 8, 2023 |
| NCT04934579 | Completed | Phase 2 | Rituximab,Methotrexate and Lenalidomide in Newly Diagnosed Primary Central Nervous System Lymphoma | January 1, 2020 | November 15, 2022 |
| NCT05208034 | Completed | N/A | Medical Treatment in Ectopic Tubal Pregnancy | January 1, 2020 | July 30, 2021 |
| NCT05279417 | Completed | Phase 2 | ATI-450 Plus MTX Versus Placebo Plus MTX in Patients With Moderate to Severe Active RA | February 1, 2022 | October 11, 2023 |
| NCT05315128 | Completed | Phase 2 | Intralesional Versus Intramuscular Methotrexate for Non-melanoma Skin Cancers | July 6, 2020 | December 6, 2021 |
| NCT05429450 | Completed | Phase 2 | Thyroid Associated Orbitopathy Treatment by Methotrexate Against Triamcinolone Periocular Injections | July 1, 2020 | July 15, 2022 |
| NCT05445440 | Completed | Phase 1 | A Study to Assess the Effects of BMS-986371 on the Drug Levels of Methotrexate in the Presence and Absence of Sulfasalazine | September 6, 2022 | November 23, 2022 |
| NCT05602675 | Completed | Phase 1 | A Drug Interaction Study of LY3871801 in Healthy Participants | November 2, 2022 | March 29, 2023 |
| NCT05615012 | Completed | Phase 1 | A Study Investigating Interactions Between BMS-986322 and Rosuvastatin, Metformin and Methotrexate in Healthy Participants | November 11, 2022 | December 13, 2023 |
| NCT05684744 | Completed | Phase 2/Phase 3 | Roflumilast Versus Methotrexate in Psoriasis | January 9, 2023 | May 14, 2023 |
| NCT06309732 | Completed | Phase 2 | GAMEC-II, Risk-adapted Protocol for Relapsed Germ Cell Tumours (GCT) | July 2006 | January 2014 |
| NCT00303810 | Completed | N/A | Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma | January 2001 | |
| NCT00309478 | Completed | Phase 3 | Randomized Study Comparing CMF and Goserelin + Tamoxifen in Premenopausal Receptor-positive Patients | December 1990 | June 2004 |
| NCT00309569 | Completed | Phase 3 | Randomized Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment in Receptor-negative Patients | October 1991 | September 2000 |
| NCT00311636 | Completed | Phase 3 | Triptorelin in Preventing Early Menopause in Premenopausal Women Who Are Receiving Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery | September 2003 | April 2008 |
| NCT00313625 | Completed | Phase 2 | Melphalan and Busulfan Followed By Donor Peripheral Stem Cell Transplant, Tacrolimus, and Methotrexate in Treating Patients With Multiple Myeloma | September 2005 | |
| NCT00317785 | Completed | Phase 2 | Total-Body Irradiation and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer and Other Diseases | May 2005 | |
| NCT00317876 | Completed | Phase 1 | Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia | June 1998 | |
| NCT00322101 | Completed | Phase 3 | Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia | January 2006 | October 2014 |
| NCT00331097 | Completed | Phase 3 | ELDA: Elderly Breast Cancer - Docetaxel in Adjuvant Treatment | July 2003 | November 2014 |
| NCT00343785 | Completed | Phase 2 | Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow Transplant | February 2006 | August 2012 |
| NCT04483466 | Enrolling by invitation | Phase 3 | Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH) | July 18, 2023 | August 30, 2027 |
| NCT04440267 | Not yet recruiting | Phase 2 | Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage | June 20, 2020 | December 20, 2025 |
| NCT06260904 | Not yet recruiting | Phase 4 | Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus | February 26, 2024 | May 31, 2025 |
| NCT06175702 | Not yet recruiting | Treatment Protocol for Newky Diagnosed Adult Ph Positive ALL | December 25, 2023 | December 25, 2030 | |
| NCT06128070 | Not yet recruiting | Phase 2 | Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome | June 14, 2024 | October 31, 2027 |
| NCT06207123 | Not yet recruiting | Phase 1/Phase 2 | A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL) | April 1, 2025 | December 1, 2026 |
| NCT04239859 | Not yet recruiting | Phase 4 | Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque Psoriasis | January 2024 | December 2027 |
| NCT06247787 | Not yet recruiting | Phase 1 | A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy | July 12, 2024 | April 1, 2026 |
| NCT06124157 | Not yet recruiting | Phase 3 | A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL) | July 22, 2024 | December 1, 2030 |
| NCT06252870 | Not yet recruiting | Phase 2 | Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation | May 15, 2024 | May 15, 2028 |
| NCT06088147 | Not yet recruiting | N/A | Methotrexate Versus Triamcinilone Acetonide in Treatment of Recalcitrant Alopecia Areata | December 2023 | June 2024 |
| NCT06015750 | Not yet recruiting | Phase 4 | Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia | April 30, 2024 | April 28, 2028 |
| NCT06001125 | Not yet recruiting | Phase 2 | Methotrexate for Immune Related Arthritis or Arthralgias (IMPACT 2.1) | October 2024 | November 2029 |
| NCT06390319 | Not yet recruiting | Phase 2 | Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL) | June 2024 | December 2033 |
| NCT06387121 | Not yet recruiting | Phase 2 | Efficacy and Safety of Low-dose Chemotherapy Plus Immuno-targeted Drugs in Newly Diagnosed Elderly/Unfit Ph- B-ALL | April 15, 2024 | December 31, 2028 |
| NCT05583071 | Not yet recruiting | Phase 2 | Methotrexate, Tafasitamab, Lenalidomide and Rituximab in Patients With PCNSL | May 2024 | April 2027 |
| NCT06317662 | Not yet recruiting | Phase 2 | Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia | July 31, 2024 | December 21, 2027 |
| NCT06301373 | Not yet recruiting | N/A | Methotrexate Combined With Tofacitinib in Rheumatoid Arthritis | April 1, 2024 | April 1, 2030 |
| NCT05303727 | Not yet recruiting | Phase 2 | Allogeneic Hematopoietic Stem Cell Transplantation for 4/M Neuroblastoma | August 2022 | August 2027 |
| NCT06204614 | Not yet recruiting | Early Phase 1 | Drug Screening Using IMD in Bladder Cancer | February 14, 2024 | July 1, 2025 |
| NCT06300333 | Not yet recruiting | Treatment of Ectopic Pregnancy by Low Dose of Methotrexate | March 2024 | March 2025 | |
| NCT06289673 | Not yet recruiting | Phase 4 | Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma | July 2024 | May 2039 |
| NCT06281184 | Not yet recruiting | A Post-trial Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate Treatment in Adults With Erosive Hand OA. | March 15, 2024 | February 1, 2027 | |
| NCT04216524 | Recruiting | Phase 2 | Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm | May 29, 2020 | December 31, 2026 |
| NCT04237103 | Recruiting | Phase 2 | Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults With Progressive Vitiligo | May 23, 2023 | October 10, 2025 |
| NCT04314219 | Recruiting | Phase 3 | Comparing Post-Transplant Cyclophosphamide as GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients | August 15, 2021 | December 2026 |
| NCT04383743 | Recruiting | Phase 2 | Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer | November 24, 2020 | October 28, 2025 |
| NCT04384692 | Recruiting | Phase 2 | Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis | December 18, 2020 | December 31, 2029 |
| NCT04481815 | Recruiting | Phase 2 | Rituximab Plus Methotrexate With or Without Lenalidomide in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | October 1, 2020 | December 30, 2025 |
| NCT02203526 | Recruiting | Phase 1 | Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma | August 14, 2014 | June 15, 2027 |
| NCT02205762 | Recruiting | Phase 2/Phase 3 | LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis | November 2, 2016 | July 2025 |
| NCT04530565 | Recruiting | Phase 3 | Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults | January 25, 2021 | July 1, 2028 |
| NCT04537689 | Recruiting | Phase 4 | Outcomes With Treatment and Withdraw of Ixekizumab in Patients With Plaque Psoriasis | December 10, 2020 | December 31, 2027 |
| NCT04562558 | Recruiting | N/A | Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia | September 29, 2020 | December 2025 |
| NCT06262438 | Recruiting | Phase 2 | CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients | February 6, 2024 | June 2032 |
| NCT04609046 | Recruiting | Phase 1 | Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma | May 24, 2021 | May 31, 2025 |
| NCT04610476 | Recruiting | Phase 3 | Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis | October 19, 2020 | October 19, 2025 |
| NCT04628767 | Recruiting | Phase 2/Phase 3 | Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer | November 12, 2021 | September 30, 2027 |
| NCT04725422 | Recruiting | CHronic Nonbacterial Osteomyelitis International Registry (CHOIR) | August 1, 2018 | August 2050 | |
| NCT04737889 | Recruiting | Phase 2 | Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma | January 13, 2021 | January 13, 2026 |
| NCT04747912 | Recruiting | Phase 2 | Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO) | March 2, 2021 | May 1, 2026 |
| NCT06289205 | Recruiting | Phase 1/Phase 2 | "Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy" | March 2024 | May 2025 |
| NCT00501826 | Recruiting | Phase 2 | Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | July 11, 2007 | October 31, 2024 |
| NCT04798755 | Recruiting | Phase 3 | Efficacy, Safety and Costs of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis | January 12, 2022 | October 1, 2025 |
| NCT04872790 | Recruiting | Phase 1 | Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia | September 2, 2022 | June 2, 2026 |
| NCT04898894 | Recruiting | Phase 1 | Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia | November 15, 2021 | July 2025 |
| NCT04899453 | Recruiting | Phase 2 | Intravitreal MTX and ZR Regimen in Newly Diagnosed PVRL | August 1, 2020 | August 1, 2024 |
| NCT04944524 | Recruiting | Phase 4 | Comparison of Tofacitinib and Methotrexate in the Maintained Treatment of GPA | July 1, 2021 | July 1, 2024 |
| NCT04965597 | Recruiting | Phase 2 | Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) | April 19, 2022 | December 2026 |
| NCT05032183 | Recruiting | Phase 1/Phase 2 | Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | February 17, 2022 | July 1, 2025 |
| NCT05054426 | Recruiting | Phase 3 | Intermediate Dose of IV MTX as CNS Prophylaxis for High Risk DLBCL | October 8, 2021 | October 8, 2025 |
| NCT05102448 | Recruiting | Phase 4 | Comparison of Tofacitinib and Methotrexate in Takayasu's Arteritis | November 1, 2021 | December 31, 2025 |
| NCT05137262 | Recruiting | Phase 2 | A Phase II Multicenter Study of Chemotherapy Versus Chemotherapy Plus Durvalumab (MEDI 4736) in Patients With Lymph Node Positive Urothelial Carcinoma of the Bladder | October 13, 2021 | August 31, 2026 |
| NCT02611492 | Recruiting | Phase 3 | A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults | April 2016 | December 2025 |
| NCT05157971 | Recruiting | Phase 1 | Venetoclax and a Pediatric-Inspired Regimen for the Treatment of Newly Diagnosed B Cell Acute Lymphoblastic Leukemia | March 17, 2022 | May 22, 2024 |
| NCT02639650 | Recruiting | Phase 3 | Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor | March 1, 2016 | March 1, 2026 |
| NCT06298071 | Recruiting | Phase 1 | A Phase Ib Clinical Trial of Peguricase for Injection With Methotrexate in Patients With Uncontrolled Gout. | March 3, 2023 | December 30, 2025 |
| NCT05292664 | Recruiting | Phase 1 | Venetoclax Basket Trial for High Risk Hematologic Malignancies | March 29, 2023 | April 2, 2027 |
| NCT05303792 | Recruiting | Phase 2 | Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma | February 27, 2023 | May 2028 |
| NCT05353829 | Recruiting | Phase 4 | Methotrexate in Patients With Early Rheumatoid Arthritis | April 28, 2022 | December 31, 2026 |
| NCT05390749 | Recruiting | Phase 2 | Sequential Treatment With RO-MTX After Pomalidomide, Orelabrutinib, Rituximab (POR) in Newly-diagnosed PCNSL | April 11, 2022 | April 1, 2026 |
| NCT05457556 | Recruiting | Phase 3 | Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome | March 15, 2023 | December 1, 2027 |
| NCT05476770 | Recruiting | Phase 1 | Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies | November 11, 2022 | November 11, 2027 |
| NCT05494593 | Recruiting | Phase 4 | A Study of ELAPRASE in Treatment-naïve Participants With Hunter Syndrome (Mucopolysaccharidosis [MPS] II) | February 28, 2023 | June 15, 2027 |
| NCT05508815 | Recruiting | Early Phase 1 | Modified Zhiwang Decoction Combined With Methotrexate in the Treatment of Early Rheumatoid Arthritis | February 9, 2023 | December 31, 2024 |
| NCT05519579 | Recruiting | Phase 2 | Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia | June 30, 2023 | August 1, 2025 |
| NCT05533372 | Recruiting | Phase 1 | MAD Study of IA-14069 | October 10, 2022 | December 2024 |
| NCT05535166 | Recruiting | Phase 2 | Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma | December 20, 2022 | July 2035 |
| NCT02877303 | Recruiting | Phase 2 | Blinatumomab, Inotuzumab Ozogamicin, and Combination Chemotherapy as Frontline Therapy in Treating Patients With B Acute Lymphoblastic Leukemia | November 1, 2016 | November 1, 2026 |
| NCT05579769 | Recruiting | Phase 2 | A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological Malignancies | November 4, 2022 | April 2027 |
| NCT05594680 | Recruiting | Phase 3 | Cilostazol and Methotrexate in Rheumatoid Arthritis | October 1, 2022 | November 1, 2024 |
| NCT02905110 | Recruiting | Early Phase 1 | Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Brain Tumors | October 2016 | November 2025 |
| NCT05600426 | Recruiting | Phase 3 | A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202) | January 25, 2023 | December 2029 |
| NCT02981628 | Recruiting | Phase 2 | Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia | June 19, 2017 | March 31, 2026 |
| NCT03007147 | Recruiting | Phase 3 | Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia | August 8, 2017 | September 30, 2027 |
| NCT05600660 | Recruiting | Phase 2 | Orelabrutinib,Rituximab and Methotrexate in Newly Diagnosed Primary Central Nervous System Lymphoma | August 1, 2022 | December 31, 2027 |
| NCT06336395 | Recruiting | Phase 2 | Ma-Spore ALL 2020 Study | March 4, 2020 | March 2030 |
| NCT03121014 | Recruiting | Phase 2 | Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes | April 24, 2017 | April 24, 2024 |
| NCT05626348 | Recruiting | Phase 4 | The Clinical Efficacy of Immunomodulators in RA Patients | December 22, 2021 | December 31, 2026 |
| NCT05645718 | Recruiting | Phase 2 | Study of Pedi-cRIB: Mini-Hyper-CVD With Condensed Rituximab, Inotuzumab Ozogamicin and Blinatumomab (cRIB) for Relapsed Therapy for Pediatric With B-Cell Lineage Acute Lymphocytic Leukemia | July 14, 2023 | December 31, 2029 |
| NCT03206671 | Recruiting | Phase 3 | Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents | August 3, 2017 | August 2024 |
| NCT05660473 | Recruiting | Phase 2 | Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia | October 31, 2022 | December 30, 2027 |
| NCT03254589 | Recruiting | Phase 4 | Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis | October 1, 2017 | December 31, 2024 |
| NCT03263572 | Recruiting | Phase 2 | Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia | November 29, 2017 | November 30, 2025 |
| NCT03277924 | Recruiting | Phase 1/Phase 2 | Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas | May 31, 2017 | June 30, 2025 |
| NCT03286634 | Recruiting | Phase 2 | ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 | April 18, 2017 | March 31, 2033 |
| NCT05698147 | Recruiting | Phase 1/Phase 2 | Selinexor in Combination With MTX+Ritu to Treat R/R CNSL | August 3, 2023 | December 31, 2026 |
| NCT05725200 | Recruiting | Phase 2 | Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer | September 27, 2022 | December 31, 2040 |
| NCT03360760 | Recruiting | N/A | Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum | August 1, 2018 | February 2025 |
| NCT05761171 | Recruiting | Phase 2 | A Study of SNDX-5613 in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia | January 8, 2024 | December 31, 2027 |
| NCT05790330 | Recruiting | Mind and Skin - the Neurocutaneous Axis in Atopic Eczema | March 10, 2023 | June 1, 2027 | |
| NCT03414502 | Recruiting | Phase 3 | Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response | December 10, 2007 | March 2028 |
| NCT03440892 | Recruiting | Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis Patients | November 1, 2017 | January 2025 | |
| NCT05848687 | Recruiting | Phase 1/Phase 2 | TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II | November 3, 2023 | December 2033 |
| NCT05896007 | Recruiting | Phase 2 | Zanubrutinib Combined With Rituximab and Chemotherapy for Newly-Diagnosed PCNSLBCL Patients Intolerant to HSCT | July 13, 2023 | December 31, 2025 |
| NCT03495960 | Recruiting | Phase 2 | Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System | June 15, 2019 | December 31, 2024 |
| NCT01371630 | Recruiting | Phase 1/Phase 2 | Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia | August 26, 2011 | December 25, 2025 |
| NCT05959720 | Recruiting | Adult Acute Lymphoblastic Leukemia Treated With Pediatric Regimen in Brazil | September 5, 2023 | June 2030 | |
| NCT03531073 | Recruiting | Multicentre ObservatioNal Initiative in Treat to Target Outcomes in Psoriatic Arthritis | April 18, 2018 | February 2025 | |
| NCT03569995 | Recruiting | Phase 2 | [CREMA]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma | November 30, 2018 | June 2025 |
| NCT05984381 | Recruiting | Phase 4 | Efficacy and Safety of add-on Dapsone Versus add-on Methotrexate in Patients With Bullous Pemphigoid | August 1, 2023 | December 1, 2024 |
| NCT03593759 | Recruiting | Phase 3 | Cardiac Sarcoidosis Randomized Trial | January 15, 2019 | December 2025 |
| NCT03643276 | Recruiting | Phase 3 | Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 | July 15, 2018 | July 14, 2028 |
| NCT03684980 | Recruiting | Early Phase 1 | LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma | November 14, 2018 | November 2025 |
| NCT05998642 | Recruiting | Phase 2 | Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma | February 13, 2024 | December 31, 2028 |
| NCT03703271 | Recruiting | Phase 3 | Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia | March 1, 2019 | December 31, 2023 |
| NCT03719105 | Recruiting | Early Phase 1 | Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma | March 1, 2019 | December 31, 2026 |
| NCT03739853 | Recruiting | Phase 4 | Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED Trial | May 14, 2019 | February 2025 |
| NCT03746223 | Recruiting | Phase 2 | Intravitreal Methotrexate and R2(Rituximab & Lenalidomide) Regimen in Newly-diagnosed Primary Vitreoretinal Lymphoma | November 15, 2018 | October 15, 2025 |
| NCT03775460 | Recruiting | N/A | Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum | January 15, 2023 | December 1, 2024 |
| NCT03779854 | Recruiting | Phase 2 | Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant | August 29, 2019 | December 31, 2025 |
| NCT06085742 | Recruiting | Phase 2 | BRE-08 Phase II Study of CMC Regimen for Early Stage Breast Cancer | November 22, 2023 | September 2034 |
| NCT01706692 | Recruiting | Swiss Dermatology Network of Targeted Therapies (SDNTT) | July 2011 | June 2033 | |
| NCT03842696 | Recruiting | Phase 1/Phase 2 | Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation | February 4, 2020 | June 30, 2026 |
| NCT03913559 | Recruiting | Phase 2 | Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia | May 14, 2019 | January 2025 |
| NCT03914625 | Recruiting | Phase 3 | A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia | July 3, 2019 | June 30, 2029 |
| NCT03959085 | Recruiting | Phase 3 | Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy | October 31, 2019 | March 31, 2030 |
| NCT06177067 | Recruiting | Phase 1 | Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia | April 19, 2024 | July 2026 |
| NCT03970096 | Recruiting | Phase 2 | Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) | November 19, 2019 | December 31, 2028 |
| NCT04043494 | Recruiting | Phase 3 | International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma | August 23, 2019 | November 22, 2027 |
| NCT04120350 | Recruiting | Phase 1/Phase 2 | R2-MTX With Lenalidomide Maintenance in Newly-diagnosed PCNSL：a Multicenter Phase Ib/II Stuty | August 16, 2019 | August 2024 |
| NCT04129710 | Recruiting | Phase 2 | A Trial to Compare Ibrutinib Versus Lenalidomide in Combination With MRE-chemotherapy for Adult Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL) | January 1, 2020 | December 31, 2025 |
| NCT06229145 | Recruiting | Phase 4 | A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory Gout | January 22, 2024 | May 31, 2026 |
| NCT06231745 | Recruiting | Phase 3 | Paroxetine Safety and Efficacy in Rheumatoid Arthritis | January 31, 2024 | February 20, 2026 |
| NCT06239311 | Recruiting | Phase 3 | Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis. | February 27, 2024 | March 2026 |
| NCT05691478 | Suspended | Phase 2/Phase 3 | A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma | March 3, 2023 | March 20, 2030 |
| NCT03150693 | Suspended | Phase 3 | Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia | June 1, 2017 | August 2025 |
| NCT00002696 | Suspended | Phase 3 | Combination Chemotherapy in Treating Women With Stage III Breast Cancer | October 1995 | |
| NCT04546399 | Suspended | Phase 2 | A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) | December 4, 2020 | June 30, 2028 |
| NCT04095858 | Terminated | Phase 3 | Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) | January 5, 2021 | November 5, 2021 |
| NCT05263505 | Terminated | Phase 2 | Baricitinib for the Treatment of Ocular Mucous Membrane Pemphigoid | February 21, 2022 | September 11, 2023 |
| NCT03860844 | Terminated | Phase 2 | Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia | August 6, 2019 | May 26, 2023 |
| NCT03864419 | Terminated | Phase 1 | Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda | October 24, 2019 | July 26, 2023 |
| NCT00001880 | Terminated | Phase 2 | Stem Cell Transplantation for Metastatic Solid Tumors | March 12, 1999 | August 13, 2020 |
| NCT01518153 | Terminated | Phase 2 | Planned Donor Lymphocyte Infusion (DLI) After Allogeneic Stem Cell Transplantation (SCT) | February 2012 | August 2014 |
| NCT01629511 | Terminated | Phase 1/Phase 2 | Allogeneic Stem Cell Transplant for CLL | November 21, 2012 | April 25, 2018 |
| NCT00555048 | Terminated | Phase 1/Phase 2 | Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer | September 2007 | |
| NCT03912818 | Terminated | Phase 2 | Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer | April 10, 2019 | August 11, 2022 |
| NCT01186328 | Terminated | Phase 1 | EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL) | August 24, 2010 | January 10, 2012 |
| NCT01764997 | Terminated | Phase 3 | An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate | April 2013 | January 2015 |
| NCT01187810 | Terminated | Phase 1 | Fenretinide in Children With Recurrent/Resistant ALL, AML, and NHL | August 2010 | April 2018 |
| NCT01964755 | Terminated | Phase 2 | Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma | April 21, 2009 | June 7, 2018 |
| NCT00262925 | Terminated | Phase 2 | Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia | June 2006 | February 2013 |
| NCT01198002 | Terminated | Phase 3 | A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate | December 2010 | January 2014 |
| NCT04311567 | Terminated | Phase 4 | Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease | November 7, 2020 | March 26, 2024 |
| NCT00253552 | Terminated | N/A | G-CSF-Treated Donor Bone Marrow Transplant in Treating Patients With Hematologic Disorders | May 2004 | May 2006 |
| NCT01230827 | Terminated | Phase 3 | A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS) | December 2010 | May 2014 |
| NCT00194792 | Terminated | Phase 2 | Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast Cancer | August 2005 | July 2011 |
| NCT01773395 | Terminated | Phase 2 | GVAX vs. Placebo for MDS/AML After Allo HSCT | January 8, 2013 | November 24, 2021 |
| NCT02535806 | Terminated | Phase 2 | Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young Adults | July 2015 | May 25, 2017 |
| NCT00882206 | Terminated | Phase 2 | Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia | April 2009 | January 2013 |
| NCT01483690 | Terminated | Phase 1/Phase 2 | A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL | December 2011 | July 31, 2015 |
| NCT00706797 | Terminated | Phase 4 | Study Evaluating Efficacy / Safety of Etanercept + Methotrexate Compared to Usual Treatment in Moderate RA Subjects | September 2008 | May 2010 |
| NCT01283971 | Terminated | Phase 4 | A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-Inhibitor | May 2011 | August 2012 |
| NCT00006054 | Terminated | N/A | Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies | March 2000 | December 2002 |
| NCT01312818 | Terminated | Phase 2 | Bortezomib, Vorinostat and Dexamethasone for Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) | June 2011 | January 2013 |
| NCT00005641 | Terminated | Phase 2 | Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation | September 1997 | September 2000 |
| NCT01314417 | Terminated | Phase 1/Phase 2 | Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate | February 2011 | January 2013 |
| NCT00918554 | Terminated | Phase 4 | Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis | September 2009 | August 2010 |
| NCT02420717 | Terminated | Phase 2 | Ruxolitinib Phosphate or Dasatinib With Chemotherapy in Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia | July 15, 2015 | January 20, 2021 |
| NCT00002961 | Terminated | Phase 3 | Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia | October 1995 | February 2001 |
| NCT01800162 | Terminated | Phase 1/Phase 2 | RCT for Women With a Persisting Pregnancy of Unknown Location | February 2013 | December 2013 |
| NCT03488225 | Terminated | Phase 2 | Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia | March 28, 2018 | April 2, 2020 |
| NCT02419755 | Terminated | Phase 2 | Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies | April 14, 2015 | December 31, 2016 |
| NCT00925652 | Terminated | Phase 2 | Bevacizumab, Metronomic Chemotherapy (CM), Diet and Exercise After Preoperative Chemotherapy for Breast Cancer | September 2010 | January 30, 2019 |
| NCT00499889 | Terminated | Phase 2 | Imatinib Mesylate, Busulfan, Fludarabine, and Antithymocyte Globulin for CML Patients | February 2003 | November 2009 |
| NCT00005047 | Terminated | Phase 3 | 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer | August 1997 | December 2014 |
| NCT00928200 | Terminated | Phase 1 | Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) | April 13, 2009 | June 4, 2010 |
| NCT00354107 | Terminated | Phase 1/Phase 2 | Ifosfamide, Carboplatin, Etoposide, and SGN-30 in Treating Young Patients With Recurrent Anaplastic Large Cell Lymphoma | January 2007 | January 2010 |
| NCT03516903 | Terminated | Phase 2/Phase 3 | Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI | April 17, 2018 | December 17, 2020 |
| NCT03518112 | Terminated | Phase 2 | Low-Intensity Chemotherapy and Blinatumomab in Treating Patients With Philadelphia Chromosome Negative Relapsed or Refractory Acute Lymphoblastic Leukemia | April 18, 2018 | May 27, 2021 |
| NCT02862574 | Terminated | Phase 2 | Andecaliximab as Add-On Therapy to a Tumor Necrosis Factor Inhibitor and Methotrexate Regimen in Adults With Moderately to Severely Active Rheumatoid Arthritis | December 15, 2016 | August 7, 2017 |
| NCT00126191 | Terminated | Phase 2 | Intensive Chemotherapy and Rituximab in the Treatment of Burkitt Lymphoma | July 2005 | June 2011 |
| NCT00121186 | Terminated | Phase 2 | S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and Methotrexate in Treating Patients for Relapsed Lymphoma | July 2005 | December 2011 |
| NCT01862224 | Terminated | Phase 2 | A Synovial Biopsy Study of JNJ-38518168 in Participants With Active Rheumatoid Arthritis Despite Methotrexate Therapy | July 2013 | July 2014 |
| NCT00000723 | Terminated | N/A | The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer | March 1990 | |
| NCT01651936 | Terminated | Phase 2 | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Trial to Evaluate the Safety, Tolerability, and Efficacy of MK-8457 in Participants With Rheumatoid Arthritis (MK-8457-010) | August 29, 2012 | October 8, 2013 |
| NCT01390441 | Terminated | Phase 1 | A Study of the Pharmacokinetics and Safety of MK-8808 (MK-8808-002) | July 2011 | April 2014 |
| NCT00952016 | Terminated | Phase 2 | Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency | February 2009 | September 2014 |
| NCT00485589 | Terminated | Phase 3 | A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM) | June 11, 2007 | August 29, 2013 |
| NCT00476996 | Terminated | Phase 3 | A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Who Don't Have a Response to Anti-TNF-α Therapy (SCRIPT) | May 15, 2007 | May 14, 2018 |
| NCT01927757 | Terminated | Phase 4 | Evaluating Etanercept Use in Patients With Moderate to Severe Rheumatoid Arthritis Who Have Lost Response to Adalimumab | May 6, 2013 | June 11, 2015 |
| NCT02419469 | Terminated | Phase 2 | Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma | November 13, 2015 | June 22, 2017 |
| NCT00003910 | Terminated | Phase 2 | Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic Leukemia | September 15, 1999 | March 2012 |
| NCT00406419 | Terminated | Phase 3 | A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE) | December 27, 2006 | April 22, 2015 |
| NCT00296010 | Terminated | Phase 3 | Liposomal Doxorubicin Compared With Observation or Cyclophosphamide and Methotrexate in Treating Older Women Who Have Undergone Surgery for Breast Cancer | August 2005 | December 2011 |
| NCT00003060 | Terminated | Phase 1 | Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Metastatic Melanoma | March 1995 | February 22, 2001 |
| NCT02413047 | Terminated | N/A | Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator | May 2015 | February 2018 |
| NCT00233558 | Terminated | Phase 4 | Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid Arthritis | June 2005 | |
| NCT00616122 | Terminated | Phase 1/Phase 2 | Sunitinib, Cyclophosphamide, and Methotrexate in Treating Patients With Metastatic Breast Cancer | March 1, 2006 | December 1, 2012 |
| NCT00422942 | Terminated | Phase 2 | A Pharmacokinetic and Pharmacodynamic Study of MabThera (Rituximab) Plus Methotrexate in Patients With Rheumatoid Arthritis (RA) | January 2006 | June 2010 |
| NCT00424294 | Terminated | Phase 2 | A Study Of CP-195543 And Celecoxib Dual Therapy In Subjects With Rheumatoid Arthritis | June 2006 | February 2008 |
| NCT00981799 | Terminated | Phase 1/Phase 2 | Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL | June 2010 | July 18, 2016 |
| NCT00074269 | Terminated | Phase 2 | Allogeneic Stem Cell Transplant After ATG, High-Dose Melphalan, and Fludarabine for Patients With Breast Cancer | July 2003 | March 2008 |
| NCT00779220 | Terminated | Phase 2 | A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid Arthritis | October 2008 | March 2015 |
| NCT00439296 | Terminated | Phase 1/Phase 2 | ABT-751 With Chemotherapy for Relapsed Pediatric ALL | May 22, 2006 | September 23, 2009 |
| NCT00609739 | Terminated | Phase 1/Phase 2 | Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation | June 1999 | June 2010 |
| NCT00058461 | Terminated | Phase 2 | Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia | November 2003 | |
| NCT00673920 | Terminated | Phase 3 | A Study to Evaluate Ocrelizumab Compared With Placebo in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate Therapy | April 24, 2008 | October 26, 2009 |
| NCT01569152 | Terminated | Phase 2 | Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008) | May 22, 2012 | October 3, 2013 |
| NCT00517699 | Terminated | Phase 2 | A Study of MabThera (Rituximab) in Primary Central Nervous System Lymphoma. | September 2007 | March 2009 |
| NCT00041288 | Terminated | Phase 2 | Study Of Two Non-Myeloablative Stem Cell Transplant Strategies For Low-Grade Lymphoma And CLL | October 2001 | January 2003 |
| NCT01410695 | Terminated | Phase 2/Phase 3 | Masitinib in Refractory Active Rheumatoid Arthritis | July 2011 | October 2015 |
| NCT00298272 | Terminated | Phase 2 | Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis | May 2006 | July 2011 |
| NCT00035958 | Terminated | Phase 2/Phase 3 | Understanding the Pathogenesis and Treatment of Childhood Onset Dermatomyositis | August 2002 | August 2002 |
| NCT00450983 | Terminated | Phase 2 | Donor Peripheral Stem Cell Transplant and Donor Natural Killer Cell Transplant After Total-Body Irradiation, Thiotepa, Fludarabine, and Muromonab-CD3 in Treating Patients With Leukemia or Other Blood Diseases | December 2006 | July 2010 |
| NCT01679951 | Terminated | Phase 2 | A Dose Range Finding Study of JNJ-38518168 in Patients With Active Rheumatoid Arthritis in Spite of Treatment With Methotrexate | October 31, 2012 | July 3, 2014 |
| NCT00281879 | Terminated | Phase 2 | Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer | February 2006 | March 2008 |
| NCT00808210 | Terminated | Phase 2 | A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab | March 5, 2009 | November 14, 2012 |
| NCT02323659 | Terminated | Phase 4 | Comparison of Methotrexate Versus Interferon-alfa 2b in Patients With Primary Cutaneous T-cell Lymphomas | June 1, 2014 | March 31, 2018 |
| NCT01005914 | Terminated | Phase 2 | Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | June 2009 | May 2014 |
| NCT02930343 | Terminated | Phase 3 | Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy | September 2016 | August 2018 |
| NCT00635726 | Terminated | Phase 2 | Methotrexate, Vinblastine, Doxorubicin and Cisplatin (MVAC) Followed by Gemcitabine Plus Cisplatin (GEM+CDDP) in Locally Advanced or Metastatic Bladder Cancer | February 2008 | February 2013 |
| NCT00516750 | Terminated | Phase 2 | Gene Expression Profiling in Patients With Invasive Bladder Cancer Receiving Methotrexate, Vinblastine, Doxorubicin, and Cisplatin | July 2007 | February 2009 |
| NCT03001219 | Terminated | Phase 2 | A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy | December 22, 2016 | November 6, 2018 |
| NCT01014767 | Terminated | Phase 3 | Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors | November 2009 | January 2014 |
| NCT00578903 | Terminated | Phase 2 | Allogeneic Stem Cell Transplant for Patients With Severe Aplastic Anemia | February 2002 | July 2012 |
| NCT00720629 | Terminated | Phase 2 | Visilizumab for the Prevention of Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation | December 2007 | December 2013 |
| NCT00000361 | Terminated | Phase 3 | Autoimmunity in Inner Ear Disease | March 1998 | November 2002 |
| NCT00669890 | Terminated | Phase 1 | Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML | May 2004 | December 2013 |
| NCT00818961 | Terminated | Phase 2 | Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | May 2005 | March 2012 |
| NCT00632827 | Terminated | Phase 2 | Treatment of PTCL With Aggressive Induction Therapy Followed by Autologous SCT Using Denileukin Diftitox (Ontak) | July 1, 2008 | June 23, 2016 |
| NCT02393378 | Terminated | Phase 2 | Namilumab vs Adalimumab in Participants With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate | April 8, 2015 | November 16, 2016 |
| NCT03781375 | Terminated | Phase 3 | Etanercept Plus Methotrexate Versus Methotrexate Alone in Children With Polyarticular Course Juvenile Rheumatoid Arthritis | August 24, 2000 | June 24, 2002 |
| NCT00019864 | Terminated | Phase 2 | Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma | March 2000 | October 2011 |
| NCT02022358 | Terminated | Phase 2 | Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays? | July 2007 | June 2015 |
| NCT00275106 | Terminated | Phase 3 | Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma | September 2004 | August 2012 |
| NCT00335140 | Terminated | Phase 2 | Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System Lymphoma | August 23, 2007 | July 2015 |
| NCT01117129 | Terminated | Phase 4 | A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR) | April 2010 | June 2010 |
| NCT01118013 | Terminated | Phase 2 | Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant | December 2010 | August 2013 |
| NCT00003640 | Terminated | Phase 2 | Transurethral Resection and Combination Chemotherapy in Treating Patients With Stage II or Stage III Bladder Cancer | September 1998 | |
| NCT00673179 | Terminated | N/A | Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient Chemotherapy | May 2008 | November 2010 |
| NCT00301860 | Terminated | N/A | Donor Stem Cell Transplant Followed By Donor White Blood Cell Infusions in Treating Young Patients With Hematologic Cancer | January 2003 | November 2007 |
| NCT01158885 | Terminated | Phase 2 | Clofarabine With Cytarabine for Patients With Minimal Residual Disease Positive Leukemia | August 2010 | October 24, 2012 |
| NCT04379219 | Unknown status | Phase 4 | Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy | December 1, 2019 | December 2020 |
| NCT00647049 | Unknown status | Phase 2 | Freiburg ZNS-NHL Study | January 2007 | August 2013 |
| NCT02590510 | Unknown status | Phase 4 | Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis | October 2015 | |
| NCT01548001 | Unknown status | Phase 4 | Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis | May 2012 | January 2017 |
| NCT00656591 | Unknown status | Community-Based Interventions for Infant Health in Nepal | March 2005 | December 2008 | |
| NCT03728478 | Unknown status | Phase 3 | STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS | May 29, 2019 | February 28, 2024 |
| NCT00666354 | Unknown status | Phase 2 | Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis | October 2007 | January 2009 |
| NCT02631239 | Unknown status | Phase 3 | MESA Versus ESA in the Treatment of Early Stage NK/T-cell Lymphoma | March 16, 2016 | July 17, 2022 |
| NCT00669812 | Unknown status | Phase 2 | High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma | February 2008 | |
| NCT04308343 | Unknown status | N/A | The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy | March 30, 2020 | September 1, 2022 |
| NCT00002498 | Unknown status | Phase 2 | Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer | July 1992 | |
| NCT00281905 | Unknown status | Phase 2 | Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors | June 1992 | |
| NCT00687648 | Unknown status | Phase 2 | Cyclophosphamide, Methotrexate, and Prednisolone With or Without Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer | May 2008 | |
| NCT00689845 | Unknown status | N/A | Combination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymphoma | June 2007 | |
| NCT00716248 | Unknown status | Phase 4 | Bucillamine Study of Holding Remission After Infliximab Dose-off | January 2007 | |
| NCT02660762 | Unknown status | Phase 2 | Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL | January 2016 | January 2019 |
| NCT00002532 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia | January 1993 | |
| NCT00012311 | Unknown status | Phase 2 | Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Chemotherapy Alone in Treating Women With Stage IV Breast Cancer | January 2000 | |
| NCT02690922 | Unknown status | Phase 4 | Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients | March 2016 | May 2017 |
| NCT00751517 | Unknown status | Phase 2 | Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides | ||
| NCT00002557 | Unknown status | Phase 2 | Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides | June 1993 | |
| NCT04170504 | Unknown status | Phase 2/Phase 3 | Efficacy of Chinese Herbal Medicine Qing Re Huo Xue in Patients With Rheumatoid Arthritis | November 2019 | June 2021 |
| NCT00764907 | Unknown status | Phase 3 | Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia | November 2002 | |
| NCT02715947 | Unknown status | Phase 2 | Pharmacogenomics Study on Treatment of Psoriasis Vulgaris by Methotrexate | December 2015 | December 2017 |
| NCT02722694 | Unknown status | Phase 3 | A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate | August 2016 | December 2017 |
| NCT00006056 | Unknown status | N/A | Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders | March 2000 | |
| NCT05427175 | Unknown status | Phase 4 | Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum Chitotriosidase Level in Psoriasis | January 10, 2022 | September 15, 2023 |
| NCT00343369 | Unknown status | N/A | Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia | January 2003 | |
| NCT02764515 | Unknown status | Phase 4 | Kunxian for the Treatment of Rheumatoid Arthritis | September 2015 | November 2017 |
| NCT01617590 | Unknown status | N/A | Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy Research | May 2012 | May 2014 |
| NCT00003261 | Unknown status | Phase 2 | Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma | May 1997 | |
| NCT02776605 | Unknown status | Phase 2 | Ponatinib With Chemotherapy for Young Adults Ph Positive Acute Lymphoblastic Leukemia | June 2016 | August 2023 |
| NCT02777736 | Unknown status | Phase 3 | CNS Prophylaxis in Diffuse Large B-cell Lymphoma | July 2015 | December 2019 |
| NCT00278278 | Unknown status | Phase 3 | Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas | September 2003 | |
| NCT02799888 | Unknown status | Phase 2 | Maraviroc-Based GVHD Prophylaxis in HLA-Unrelated and HLA-Mismatched Related Transplantation | April 2014 | April 2017 |
| NCT01633983 | Unknown status | Phase 2 | Methotrexate for Central Serous Chorioretinopathy Treatment Trial | August 2012 | July 2015 |
| NCT02852694 | Unknown status | Phase 4 | Reduce Risk for Crohn's Disease Patients | February 28, 2017 | July 2022 |
| NCT00974792 | Unknown status | Phase 2 | Combination Chemotherapy and Rituximab in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma | January 2006 | |
| NCT00989352 | Unknown status | Phase 2 | Methotrexate-based Chemo-immunotherapy Followed by Maintenance Therapy for Patients > 65 Years With Central Nervous System (CNS)-Lymphoma | September 2009 | September 2011 |
| NCT02885597 | Unknown status | Phase 2/Phase 3 | Juanbi Pill for Rheumatoid Arthritis | July 2018 | December 2020 |
| NCT02894645 | Unknown status | Phase 4 | Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study | October 2008 | |
| NCT02897011 | Unknown status | N/A | 2-week dc of MTX and Influenza Vaccination in RA | September 2016 | August 2017 |
| NCT02054442 | Unknown status | Phase 1/Phase 2 | A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck | August 2016 | December 2022 |
| NCT01005758 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | January 2009 | |
| NCT02934204 | Unknown status | Phase 2 | Temozolomide in Treatment of Patients With Primary Central Nervous System Lymphoma | February 2016 | February 2019 |
| NCT00317408 | Unknown status | N/A | Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma | April 2004 | |
| NCT00003728 | Unknown status | Phase 3 | Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma | December 1998 | |
| NCT01031030 | Unknown status | Phase 3 | Cyclophosphamide, Methotrexate, and Fluorouracil, With or Without Epirubicin Hydrochloride, in Treating Women Who Have Undergone Surgery for Breast Cancer (Group III Closed to New Patients as of 12/7/2009) | November 1997 | |
| NCT01709760 | Unknown status | Phase 3 | A Phase III Study to Evaluate the Efficacy and Safety of ENIA11 in Combination With Methotrexate Versus Methotrexate Alone in Patients With RA | November 2012 | December 2019 |
| NCT03813771 | Unknown status | Phase 4 | Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell Stratification | March 2019 | February 2023 |
| NCT03063983 | Unknown status | Phase 2 | Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic Osteosarcoma | January 2, 2017 | January 31, 2022 |
| NCT00003680 | Unknown status | Phase 3 | Standard Chemotherapy Compared With High-Dose Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Women With Advanced or Inflammatory Breast Cancer | November 1998 | |
| NCT01068405 | Unknown status | Phase 3 | Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo | March 2010 | March 2012 |
| NCT00002487 | Unknown status | Phase 2 | Methotrexate Plus Dipyridamole in Treating Patients With Advanced Ovarian Cancer | July 1991 | |
| NCT03171831 | Unknown status | Phase 4 | Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major | April 1, 2017 | April 1, 2022 |
| NCT01741558 | Unknown status | Phase 2 | The Effects of mETHotrexate Therapy on ST Segment Elevation MYocardial InfarctionS (TETHYS Trial) | April 2013 | December 2014 |
| NCT00334672 | Unknown status | Phase 3 | Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic Lymphohistiocytosis | March 2006 | |
| NCT03904680 | Unknown status | Phase 4 | Studying the Effect of Methotrexate Alone Versus Methotrexate and Vitamin D on the Cardiovascular Risk of Psoriatic Patients | April 2019 | November 2019 |
| NCT03321890 | Unknown status | Phase 2 | Chidamide Combined With PECM in Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL) | March 7, 2017 | December 31, 2020 |
| NCT01786018 | Unknown status | Phase 2 | Thiotepa, Busulfan and Fludarabin for pt With Refractory/Early Relapsed Aggressive B-cell Non Hodgkin Lymphomas | February 2013 | February 2015 |
| NCT03369795 | Unknown status | Phase 2 | Add-on Methotrexate for the Treatment of Schizophrenia | December 15, 2017 | January 1, 2020 |
| NCT03925233 | Unknown status | Breast Cancer Treatment Based on Organ-like Culture | January 2, 2019 | December 15, 2021 | |
| NCT04136262 | Unknown status | Phase 2/Phase 3 | Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid Arthritis | November 25, 2019 | December 2022 |
| NCT03408756 | Unknown status | Phase 4 | Comparison of Oral Versus Subcutaneous Route of Methotrexate Administration in Moderate to Severe Psoriasis | April 1, 2018 | December 30, 2019 |
| NCT02020161 | Unknown status | Phase 4 | Clinical Guidelines for APL Treatment | June 2012 | December 2021 |
| NCT03424629 | Unknown status | Phase 1 | Safety and Efficacy of UC-MSCs in Patients With Plaque Psoriasis | June 1, 2018 | December 31, 2019 |
| NCT01358201 | Unknown status | Phase 4 | PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years | May 2010 | December 2022 |
| NCT01810926 | Unknown status | Phase 2 | T&B Depletion Non Malignant | September 2011 | October 2016 |
| NCT00131053 | Unknown status | Phase 2 | Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL) | September 2002 | September 2011 |
| NCT03505008 | Unknown status | Phase 4 | Evaluation of the Optimal MTX Dose as an Add-on Therapy to Adalimumab for RA Patients in Japan, South Korea and Taiwan | April 18, 2018 | June 30, 2022 |
| NCT01376427 | Unknown status | N/A | Treatment of Acute Lymphoblastic Leukemia Ph '(BCR / ABL) Positive Patients Aged > 55 Years | January 2007 | December 2022 |
| NCT00131027 | Unknown status | Phase 3 | High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) | September 2002 | September 2011 |
| NCT02124226 | Unknown status | Phase 3 | Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma | December 2021 | July 2022 |
| NCT00392886 | Unknown status | Phase 3 | Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors | March 2004 | |
| NCT04356222 | Unknown status | Phase 4 | Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis | June 2020 | June 2023 |
| NCT04464642 | Unknown status | Phase 4 | Tofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid Arthritis | July 10, 2019 | September 2020 |
| NCT04469829 | Unknown status | Phase 4 | Methotrexate Versus Secukinumab Safety in Psoriasis Patients With Metabolic Syndrome | August 1, 2020 | December 31, 2022 |
| NCT04482543 | Unknown status | Phase 2/Phase 3 | Repeated Methotrexate for Proliferative Vitreoretinopathy Grade C | August 1, 2020 | September 1, 2021 |
| NCT00415935 | Unknown status | PRINTO (the Paediatric Rheumatology International Trials Organisation) | December 2006 | ||
| NCT03535519 | Unknown status | Rheumatoid Arthritis Response to Methotrexate | August 7, 2018 | August 31, 2020 | |
| NCT04352465 | Unknown status | Phase 1/Phase 2 | Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients | May 1, 2020 | November 30, 2020 |
| NCT04514393 | Unknown status | Phase 2 | Ibrutinib With Methotrexate and Temozolomide for Patients With Newly Diagnosed Primary CNS Lymphoma | October 10, 2020 | June 1, 2024 |
| NCT02248792 | Unknown status | Phase 4 | Quality of Life of Patients With Psoriasis Treated With Methotrexate: Prospective, Randomized, Double-blind, Parallel Group Study. | November 2013 | |
| NCT03553238 | Unknown status | Phase 2/Phase 3 | Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL | February 14, 2016 | August 30, 2020 |
| NCT03564704 | Unknown status | Phase 2/Phase 3 | Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL | February 14, 2016 | May 30, 2021 |
| NCT02275299 | Unknown status | Phase 4 | Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis | September 2013 | February 2016 |
| NCT00455286 | Unknown status | Phase 2 | a Phase II Study in Primary Central Nervous System Lymphoma | November 2006 | November 2011 |
| NCT00003437 | Unknown status | Phase 3 | Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia | January 1997 | |
| NCT00243750 | Unknown status | Phase 2 | Methotrexate in Ankylosing Spondylitis (MTX in AS) | September 2003 | November 2005 |
| NCT01860690 | Unknown status | Phase 4 | BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success | November 2011 | February 2014 |
| NCT00295997 | Unknown status | N/A | Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia | May 2005 | |
| NCT00293475 | Unknown status | Phase 1/Phase 2 | Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma | October 14, 2005 | January 31, 2023 |
| NCT04677868 | Unknown status | Phase 2 | MTX and Steroid for aGVHD Treatment | December 23, 2020 | June 2022 |
| NCT00002531 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia | January 1993 | |
| NCT02342145 | Unknown status | Phase 4 | Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major | June 2014 | December 2018 |
| NCT04009525 | Unknown status | Phase 4 | Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study | June 1, 2019 | May 31, 2023 |
| NCT00003423 | Unknown status | Phase 3 | Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma | May 1995 | |
| NCT04811911 | Unknown status | Phase 4 | Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum TWEAK Level in Psoriasis | December 13, 2020 | December 15, 2021 |
| NCT03692416 | Unknown status | Phase 3 | The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children | November 11, 2018 | May 11, 2022 |
| NCT00002499 | Unknown status | Phase 2/Phase 3 | Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia | January 1990 | |
| NCT02085655 | Unknown status | Phase 3 | PEG-ASP+Gemox Regimen and Thalidomide for NK/T Lymphoma | April 25, 2013 | December 31, 2022 |
| NCT02416388 | Unknown status | Phase 2/Phase 3 | Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR | January 2015 | |
| NCT00291915 | Unknown status | Phase 4 | Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis | May 2004 | March 2007 |
| NCT00550992 | Unknown status | N/A | Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia | January 2006 | |
| NCT00287924 | Unknown status | Phase 2 | High-Dose Methotrexate in Treating Young Patients With Residual Ependymoma | March 2005 | |
| NCT00558519 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia | March 12, 2008 | |
| NCT00033683 | Unknown status | Phase 2 | Combination Chemotherapy in Treating Women With Resected Breast Cancer | February 2001 | |
| NCT00002701 | Unknown status | Phase 3 | Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia | October 1995 | |
| NCT04958538 | Unknown status | Phase 2 | MTX and Steroid for III-IV aGVHD Treatment | April 21, 2021 | January 30, 2023 |
| NCT02478424 | Unknown status | Phase 2 | Extended Use of Cannabidiol for the Prevention of Graft-versus-host-disease | July 2015 | June 2017 |
| NCT04967950 | Unknown status | Phase 1 | An Efficacy Study of Secukinumab In Enthesitis of Psoriatic Arthritis Patients | July 15, 2021 | December 31, 2022 |
| NCT00025636 | Unknown status | Phase 3 | Combination Chemotherapy and Peripheral Stem Cell Transplant in Treating Patients With Relapsed Hodgkin's Lymphoma | July 2001 | |
| NCT05008887 | Unknown status | Phase 4 | Fractional CO2 Laser-assisted Cutaneous Delivery of Methotrexate Versus 5-fluorouracil in Stable Non-segmental Vitiligo | September 2022 | April 2023 |
| NCT05015335 | Unknown status | Phase 4 | The Efficacy and Safety of Adalimumab in Non-infectious Anterior Pediatric Uveitis With Peripheral Vascular Leakage | August 19, 2021 | July 2023 |
| NCT05049473 | Unknown status | Phase 2 | Treatment of Mature B-ALL and Burkitt Lymphoma (BL) in Adult Patients. BURKIMAB-14. | January 2014 | January 2024 |
| NCT02525172 | Unknown status | Phase 4 | Immune Modulation Therapy for Pompe Disease | August 2015 | July 2020 |
| NCT04077957 | Unknown status | Phase 4 | Treat-to-target Strategy in Ankylosing Spondylitis Using Etanercept and Conventional Synthetic DMARDs | October 7, 2019 | July 2, 2022 |
| NCT00006451 | Withdrawn | Phase 3 | Bone Marrow Transplantation in Treating Patients With Leukemia | April 1996 | November 2000 |
| NCT00004878 | Withdrawn | Phase 2 | Donor Lymphocytes to Prevent Graft-Versus-Host Disease in Patients With Chronic Myeloid Leukemia | ||
| NCT00019409 | Withdrawn | Phase 3 | Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia | October 1999 | July 2001 |
| NCT00037115 | Withdrawn | Phase 4 | Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event. | May 2002 | December 2002 |
| NCT00621036 | Withdrawn | Phase 2 | Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma | October 19, 2007 | December 8, 2008 |
| NCT00920608 | Withdrawn | Phase 1 | A Study to Assess the Pharmacokinetics of Methotrexate Given With and Without AZD9056 in Rheumatoid Arthritis Patients | May 2009 | September 2009 |
| NCT00397501 | Withdrawn | Phase 1/Phase 2 | BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain | October 2013 | October 2013 |
| NCT01639521 | Withdrawn | Phase 2 | Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer | May 2013 | May 2013 |
| NCT02795299 | Withdrawn | Phase 2 | Study Evaluating Gerilimzumab´s Safety/Efficacy for Patients MTX or TNFα Antagonist Failed in Rheumatoid Arthritis | January 2018 | September 2019 |
| NCT00081055 | Withdrawn | Phase 2 | OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing Donor Peripheral Stem Cell Transplantation for Hematologic Malignancies | ||
| NCT05320380 | Withdrawn | Phase 1/Phase 2 | A Study of the Drug IMGN632 in Children With Leukemia That Has Come Back After Treatment or is Difficult to Treat | August 1, 2023 | September 1, 2023 |
| NCT01438021 | Withdrawn | N/A | Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | September 2012 | |
| NCT03719560 | Withdrawn | Phase 2 | Early Systemic Central Nervous System Prophylaxis in Diffuse Large B-cell Lymphoma | July 1, 2019 | December 31, 2025 |
| NCT03602898 | Withdrawn | Phase 2 | Comparing ATG or Post-Transplant Cyclophosphamide to Calcineurin Inhibitor-Methotrexate as GVHD Prophylaxis After Myeloablative Unrelated Donor Peripheral Blood Stem Cell Transplantation | June 1, 2021 | September 17, 2023 |
| NCT00734773 | Withdrawn | Early Phase 1 | Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL | November 2008 | |
| NCT00002790 | Withdrawn | Phase 1/Phase 2 | Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Receiving a Bone Marrow Transplant | March 1996 | |
| NCT00230035 | Withdrawn | Phase 2 | Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST) | September 2005 | |
| NCT00003536 | Withdrawn | Phase 2 | Methotrexate With or Without Antineoplaston Therapy in Treating Postmenopausal Women With Advanced Refractory Breast Cancer | ||
| NCT00003273 | Withdrawn | Phase 2 | Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor | November 1997 | |
| NCT04830878 | Withdrawn | Phase 1 | Methotrexate For The Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric Patients | April 2021 | April 2024 |
| NCT00301912 | Withdrawn | Phase 2 | Busulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer | January 2002 | |
| NCT06210750 | Withdrawn | Phase 2 | Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL) | August 9, 2024 | September 22, 2026 |
| NCT00513188 | Withdrawn | N/A | Combination Chemotherapy and Denileukin Diftitox in Treating Patients With Newly Diagnosed T-Cell Non-Hodgkin Lymphoma | February 2007 | |
| NCT03239600 | Withdrawn | Phase 2 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Proof of Mechanism of GSK2618960 in Primary Sjögren's Syndrome (pSS) | September 19, 2017 | October 12, 2017 |
| NCT03066466 | Withdrawn | Phase 3 | Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT | December 10, 2019 | February 28, 2021 |
| NCT04127721 | Withdrawn | Phase 2 | Itacitinib for the Prevention of Graft Versus Host Disease in Patients Undergoing Donor Stem Cell Transplantation | September 22, 2020 | September 22, 2020 |
| NCT01670084 | Withdrawn | Phase 2 | Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia | December 2012 | September 2017 |
| NCT01878318 | Withdrawn | Phase 4 | A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs | June 2013 | June 2015 |
| NCT02724904 | Withdrawn | Phase 1/Phase 2 | Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplant (HSCT) For Lymphoma | May 2017 | December 2021 |
| NCT00298012 | Withdrawn | Phase 4 | Methotrexate in the Treatment of Axial Spondyloarthritis | March 2006 |