Annotation Detail
Information
- Associated Genes
- JAK2
- Associated Variants
-
JAK2 p.Val617Phe (p.V617F)
(
ENST00000381652.4 )
JAK2 p.Val617Phe (p.V617F) ( ENST00000381652.4 ) - Associated Disease
- polycythemia vera
- Source Database
- CIViC Evidence
- Description
- TG101348 effectively inhibits STAT5 signaling in JAK2 V617F cells.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/20
- Gene URL
- https://civic.genome.wustl.edu/links/genes/28
- Variant URL
- https://civic.genome.wustl.edu/links/variants/64
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Polycythemia Vera
- Evidence Direction
- Supports
- Drug
- Fedratinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 18394554
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fedratinib | Sensitivity | true |