Annotation Detail

Information
Associated Genes
ABL1
Associated Variants
ABL1 BCR-ABL
Associated Disease
chronic myeloid leukemia
Source Database
CIViC Evidence
Description
The clinical use of imatinib in patients with BCR-ABL fusion has resulted in drastic prognostic improvements in patients with CML.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/260
Gene URL
https://civic.genome.wustl.edu/links/genes/4
Variant URL
https://civic.genome.wustl.edu/links/variants/1
Rating
5
Evidence Type
Predictive
Disease
Chronic Myeloid Leukemia
Evidence Direction
Supports
Drug
Imatinib
Evidence Level
A
Clinical Significance
Sensitivity/Response
Pubmed
20537386
Drugs
Drug NameSensitivitySupported
ImatinibSensitivitytrue