Annotation Detail

Information
Associated Genes
HRAS LRRC56
Associated Variants
HRAS p.His27= (p.H27=) ( ENST00000451590.5, ENST00000417302.7, ENST00000397596.6, ENST00000397594.7, ENST00000311189.8 )
HRAS p.His27= (p.H27=) ( ENST00000451590.5, ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7 )
Associated Disease
Costello syndrome
Source Database
ClinVar
Description
NM_005343.4(HRAS):c.81T>C (p.His27=) AND Costello syndrome
ClinVar Allele ID
48901
ClinVar RefSeq Alternation Syntax
NM_005343.4:c.81T>C
ClinVar RefSeq Alternation Syntax
NM_001130442.3:c.81T>C
ClinVar RefSeq Alternation Syntax
NM_001318054.2:c.-239T>C
ClinVar RefSeq Alternation Syntax
NM_176795.5:c.81T>C
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2024-02-01
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000659682
ClinVar Disease
Costello syndrome
Observed Origin Sample
germline
Drugs