Annotation Detail

Information
Associated Genes
C2
Associated Variants
ENSG00000244255 c.529+326_529+353delGTGGACAGGGTCAGGAATCAGGAGTCTG, C2 p.Val281_Arg283del (p.V281_R283del) ( ENST00000299367.10, ENST00000418949.6, ENST00000442278.6, ENST00000447952.7, ENST00000452323.7, ENST00000469372.5, ENST00000497706.6, ENST00000695637.1, ENST00000695638.1, ENST00000695644.1 )
ENSG00000244255 c.529+326_529+353delGTGGACAGGGTCAGGAATCAGGAGTCTG, C2 p.Val281_Arg283del (p.V281_R283del) ( ENST00000299367.10, ENST00000418949.6, ENST00000442278.6, ENST00000447952.7, ENST00000452323.7, ENST00000469372.5, ENST00000497706.6, ENST00000695637.1, ENST00000695638.1, ENST00000695644.1 )
Associated Disease
complement component 2 deficiency age related macular degeneration 14
Source Database
ClinVar
Description
NM_000063.6(C2):c.841_849+19del AND multiple conditions
ClinVar Allele ID
59668
ClinVar RefSeq Alternation Syntax
NM_001145903.3:c.445_453+19del
ClinVar RefSeq Alternation Syntax
NM_001178063.3:c.346+326_346+353del
ClinVar RefSeq Alternation Syntax
NM_001282458.2:c.754_762+19del
ClinVar RefSeq Alternation Syntax
NM_001282459.2:c.841_868del
ClinVar RefSeq Alternation Syntax
NM_001282457.2:c.111+508_111+535del
ClinVar RefSeq Alternation Syntax
NM_000063.6:c.841_849+19del
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-04-18
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002477141
ClinVar Disease
Complement component 2 deficiency
ClinVar Disease
Age related macular degeneration 14
Observed Origin Sample
unknown
Drugs