Annotation Detail
Information
- Associated Genes
- VKORC1
- Associated Variants
-
VKORC1 MUTATION
VKORC1 MUTATION - Associated Disease
- Primary Effusion Lymphoma
- Source Database
- DisGeNET
- Description
- We have recently reported that vIL-6 also associates with a novel membrane protein termed vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2) and mediates suppression of VKORC1v2-cointeracting cathepsin D, a stress-released proapoptotic protein negatively impacting HHV-8 latently infected primary effusion lymphoma (PEL) cell viability and reactivated virus productive replication.
- Pubmed
- 26018151
- Section of the abstract supporting the evidence
- IMPORTANCE
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 11
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
Drugs