Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
-
AKT1 MUTATION
AKT1 MUTATION - Associated Disease
- liver carcinoma
- Source Database
- DisGeNET
- Description
- The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) pathways was suppressed by hSulf-1, which led to a decreased expression of the target genes Cyclin D1 and Survivin, then finally induced cell cycle arrest and apoptosis in HCC cells.
- Pubmed
- 24970807
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0143864192202561
Drugs