chr14:105235686:> Detail (hg19)

Information

Genome

Assembly Position
hg19 chr14:105,235,686-105,262,096
hg38 chr14:104,769,349-104,795,759 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.001 Carcinoma, Transitional Cell NA BeFree Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
0.080 brain ischemia NA RGD Detail
0.001 Malignant tumor of cervix Additionally, treatment with butein significantly increased reactive oxygen spec... BeFree 25962638 Detail
0.003 chondrosarcoma NA BeFree,LHGDN Detail
<0.001 chordoma NA BeFree Detail
<0.001 Congenital chromosomal disease In acute myeloid leukemia (AML), several signaling pathways such as the phosphat... BeFree 25322685 Detail
0.016 Colonic Neoplasms NA BeFree,GAD,LHGDN Detail
0.010 colorectal carcinoma The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K... BeFree 24666267 Detail
0.010 colorectal carcinoma Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits const... BeFree 25365190 Detail
0.010 colorectal carcinoma Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer. BeFree 25374184 Detail
0.010 colorectal carcinoma Portrait of the PI3K/AKT pathway in colorectal cancer. BeFree 25450577 Detail
0.010 colorectal carcinoma Rare mutations not typically associated with CRC included AKT1 (4), AKT2 (1), ID... BeFree 25683705 Detail
0.010 colorectal carcinoma Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation ... BeFree 25800793 Detail
0.010 colorectal carcinoma We analyzed the mutation spectra of the PI3K/PTEN/AKT and RAS/RAF/MAPK pathways ... BeFree 25920435 Detail
0.129 Colorectal Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 Coronary Arteriosclerosis NA BeFree Detail
<0.001 Coronary heart disease NA BeFree Detail
0.003 Cessation of life NA LHGDN Detail
<0.001 Mental Depression However, the changes in AKT1 expression after lithium treatment were positively ... BeFree 25726893 Detail
<0.001 depressive disorder However, the changes in AKT1 expression after lithium treatment were positively ... BeFree 25726893 Detail
<0.001 Diabetes NA BeFree Detail
<0.001 diabetes mellitus NA BeFree Detail
0.080 Diabetes Mellitus, Experimental NA RGD Detail
0.085 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD,RGD Detail
0.003 Diabetic Angiopathies NA LHGDN Detail
<0.001 Down syndrome NA BeFree Detail
<0.001 Drug abuse NA BeFree Detail
0.002 Dyskinesia, Drug-Induced NA GAD Detail
0.013 Endometrial Neoplasms NA GAD,LHGDN Detail
0.004 endometriosis NA BeFree,GAD Detail
0.120 epilepsy NA CTD_human Detail
0.004 Esophageal Neoplasms In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathw... BeFree,LHGDN 25912437 Detail
<0.001 External exotoses For the first time mutation of AKT1 (c.49G > A) gene was detected both in crania... BeFree 25782637 Detail
<0.001 Extrapyramidal Disorders NA BeFree Detail
0.120 Fibrosis NA CTD_human Detail
<0.001 pathologic fistula NA BeFree Detail
<0.001 fragile X syndrome Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X synd... BeFree 24563264 Detail
0.016 glioblastoma AKT pathway genes define 5 prognostic subgroups in glioblastoma. BeFree,LHGDN 24984002 Detail
0.016 glioblastoma Targeting p-Hsp27 and/or p-AKT may be a potential effective strategy for the tre... BeFree,LHGDN 25200832 Detail
0.016 glioblastoma Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, b... BeFree,LHGDN 25213694 Detail
0.016 glioblastoma However, due to the development of resistance mechanisms, kinase inhibition stud... BeFree,LHGDN 25256166 Detail
0.016 glioblastoma Mechanistically, PCAF-mediated Akt1 acetylation enhanced Akt1 phosphorylation at... BeFree,LHGDN 25501279 Detail
0.016 glioblastoma We previously demonstrated that TMZ treatment of LGG induces driver mutations in... BeFree,LHGDN 25724300 Detail
0.016 glioblastoma Exogenous miR-542-3p suppressed glioblastoma cell invasion through not only targ... BeFree,LHGDN 26286747 Detail
0.014 Glioma A crucial AKT regulator, ACK1 (TNK2) has been shown to be a downstream mediator ... BeFree,LHGDN 25257795 Detail
0.014 Glioma As hyperactivation of the PI3K/AKT/mTOR pathway is frequently observed in glioma... BeFree,LHGDN 25351348 Detail
0.014 Glioma Suppressed expression of miR-637 and increased Akt1 protein levels were correlat... BeFree,LHGDN 25597410 Detail
0.014 Glioma Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma prolif... BeFree,LHGDN 25777142 Detail
0.014 Glioma VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhib... BeFree,LHGDN 25833462 Detail
0.014 Glioma Finally, inspired by these newly identified tumor-suppressive functions of PARK2... BeFree,LHGDN 25877876 Detail
<0.001 granulosa cell tumor NA BeFree Detail
<0.001 Graves Disease NA BeFree Detail
0.121 Hamartoma Syndrome, Multiple NA BeFree,ORPHANET Detail
<0.001 cardiac arrest NA BeFree Detail
0.120 Cardiomegaly NA CTD_human Detail
0.001 Heart failure Our findings not only reveal a key role of TRAF3 in regulating the hypertrophic ... BeFree 26034202 Detail
0.001 congestive heart failure Our findings not only reveal a key role of TRAF3 in regulating the hypertrophic ... BeFree 26034202 Detail
<0.001 hemangioma NA BeFree Detail
<0.001 Hematological Disease NA BeFree Detail
<0.001 hepatitis B NA BeFree Detail
<0.001 hepatitis C NA BeFree Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 Histiocytosis, Langerhans-Cell NA BeFree Detail
0.003 HIV Infections Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophage... BeFree,GAD 24983400 Detail
0.003 Hodgkin Disease NA BeFree,LHGDN Detail
<0.001 HTLV-I Infections NA BeFree Detail
0.003 Huntington disease NA LHGDN Detail
0.003 hyperglycemia NA BeFree,LHGDN Detail
0.001 hyperinsulinism NA BeFree Detail
0.120 Hyperplasia NA CTD_human Detail
0.083 Hypertensive disease NA BeFree,LHGDN,RGD Detail
<0.001 pulmonary hypertension Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypert... BeFree 25416384 Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
0.120 Inflammation NA CTD_human Detail
0.002 Insulin resistance NA GAD Detail
<0.001 insulinoma miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulin... BeFree 25919186 Detail
<0.001 Intestinal Neoplasms NA BeFree Detail
0.001 ischemia In conclusion, these findings indicate that GPNMB has neuroprotective effects ag... BeFree 25010402 Detail
<0.001 Kidney Diseases NA BeFree Detail
<0.001 Kidney Neoplasm NA BeFree Detail
<0.001 Fibroid Tumor NA BeFree Detail
<0.001 leiomyosarcoma NA BeFree Detail
0.011 leukemia The positive loops hyperactivate AKT locus forming a cancer phenotype in leukemi... BeFree,LHGDN 25164873 Detail
0.011 leukemia Using genetically modified mice, we found that loss of Id1 inhibited t(8;21) leu... BeFree,LHGDN 26084673 Detail
0.003 chronic lymphocytic leukemia Altogether, these results underline the key role of PI3K/AKT pathway in the gene... BeFree,GAD 24825182 Detail
0.003 chronic lymphocytic leukemia The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelis... BeFree,GAD 25917267 Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
<0.001 Acute Megakaryocytic Leukemias NA BeFree Detail
0.013 Leukemia, Myelocytic, Acute These data support a strong biological link between NF-kB and PI3-kinase/AKT pat... BeFree,LHGDN 24935396 Detail
0.013 Leukemia, Myelocytic, Acute In acute myeloid leukemia (AML), several signaling pathways such as the phosphat... BeFree,LHGDN 25322685 Detail
<0.001 myeloid leukemia NA BeFree Detail
0.003 Myeloid Leukemia, Chronic The present article provides an overview of our current knowledge about the crit... BeFree,LHGDN 24598853 Detail
<0.001 prolymphocytic leukemia NA BeFree Detail
0.120 acute promyelocytic leukemia NA CTD_human Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
<0.001 Adult T-Cell Lymphoma/Leukemia NA BeFree Detail
<0.001 liposarcoma NA BeFree Detail
0.003 liver cirrhosis NA BeFree,GAD Detail
<0.001 Liver diseases NA BeFree Detail
0.005 Liver neoplasms SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice. BeFree,LHGDN 25537506 Detail
0.005 Liver neoplasms Furthermore, miR-101 significantly suppressed both c-Myc and AKT/Ras liver tumor... BeFree,LHGDN 25762642 Detail
0.002 Chronic Obstructive Airway Disease NA GAD Detail
0.140 Lung Neoplasms NA BeFree,CTD_human,LHGDN Detail
<0.001 lymphadenitis AKT expression was present in all FL and lymphadenitis cases. BeFree 25096023 Detail
<0.001 lymphocytic choriomeningitis Here, we show that during chronic murine lymphocytic choriomeningitis virus infe... BeFree 25464856 Detail
0.009 lymphoma Upregulation of hClock enhanced the activity of the anti‑apoptotic gene phosphor... BeFree,LHGDN 25625359 Detail
0.009 lymphoma Hence, antagomirs to miR-BART20-5p or miR-494-3p, miR-142-3p mimics, or AKT inhi... BeFree,LHGDN 25907832 Detail
<0.001 Lymphoma, Follicular Constitutive AKT activation in follicular lymphoma. BeFree 25096023 Detail
0.010 Malignant neoplasm of stomach IL-32 contributes to gastric cancer progression by increasing the metastatic pot... BeFree 24602839 Detail
0.010 Malignant neoplasm of stomach Disruption of EGFL7-EGFR-AKT-Snail signaling may a promising therapeutic strateg... BeFree 24945379 Detail
0.010 Malignant neoplasm of stomach In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a nov... BeFree 25015565 Detail
0.010 Malignant neoplasm of stomach Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38M... BeFree 25150310 Detail
0.010 Malignant neoplasm of stomach In this review, a basic overview of the role of AKT in normal and malignant tiss... BeFree 25270272 Detail
0.010 Malignant neoplasm of stomach In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AK... BeFree 25288334 Detail
0.010 Malignant neoplasm of stomach The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a no... BeFree 25301736 Detail
0.010 Malignant neoplasm of stomach ECHS1 may play important roles in gastric cancer cell proliferation and migratio... BeFree 25338767 Detail
0.010 Malignant neoplasm of stomach Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e... BeFree 25394504 Detail
0.010 Malignant neoplasm of stomach In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree 25395073 Detail
0.010 Malignant neoplasm of stomach MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in g... BeFree 25400827 Detail
0.010 Malignant neoplasm of stomach Our studies revealed that miR-29s expression is downregulated in GC and they cou... BeFree 25428377 Detail
0.010 Malignant neoplasm of stomach Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT ... BeFree 25448881 Detail
0.010 Malignant neoplasm of stomach MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in g... BeFree 25914465 Detail
0.002 Animal Mammary Neoplasms NA GAD Detail
0.123 Marijuana Abuse Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impair... BeFree,CTD_human,GAD 25065544 Detail
<0.001 measles NA BeFree Detail
0.002 medulloblastoma Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. BeFree 25601471 Detail
0.026 melanoma These results add to the understanding of the molecular characteristics of melan... BeFree,LHGDN 24803579 Detail
0.026 melanoma The findings add to evidence supporting a significant role for PTEN loss and the... BeFree,LHGDN 25165098 Detail
0.026 melanoma Analysis of tumor adjacent normal skin from these mice revealed altered expressi... BeFree,LHGDN 25189354 Detail
0.026 melanoma BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse... BeFree,LHGDN 25624498 Detail
0.026 melanoma Activated PI3K-AKT pathway may contribute to decrease sensitivity to inhibitors ... BeFree,LHGDN 25627962 Detail
0.026 melanoma Clinical and prognostic significance of survivin, AKT and VEGF in primary mucosa... BeFree,LHGDN 25862867 Detail
0.026 melanoma Furthermore, we show that ectopically expressed SPINT2 in melanoma cells inhibit... BeFree,LHGDN 25910030 Detail
0.026 melanoma PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein... BeFree,LHGDN 26287415 Detail
<0.001 multiple endocrine neoplasia type 2A NA BeFree Detail
<0.001 multiple endocrine neoplasia type 2B NA BeFree Detail
0.121 meningioma Inhibition of TGM2 function by siRNA or cystamine induced meningioma cell death,... BeFree,CTD_human 25247996 Detail
0.121 meningioma The recent identification of somatic mutations in components of the SHH-GLI1 and... BeFree,CTD_human 25857641 Detail
<0.001 Mesothelioma Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activatio... BeFree 24722292 Detail
<0.001 Monoclonal Gammopathy of Undetermined Significance Several proapoptotic genes (AKT1 and AKT2) were down-regulated and antiapoptotic... BeFree 24816239 Detail
0.010 multiple myeloma Several proapoptotic genes (AKT1 and AKT2) were down-regulated and antiapoptotic... BeFree,LHGDN 24816239 Detail
0.010 multiple myeloma Furthermore, our results demonstrated that the enforced expression of miR-145 in... BeFree,LHGDN 25369735 Detail
0.120 muscular atrophy NA BeFree,CTD_human Detail
<0.001 spinal muscular atrophy NA BeFree Detail
<0.001 myopathy NA BeFree Detail
<0.001 mycosis fungoides We have already shown that AKT is activated in skin lesions in Mycosis Fungoides... BeFree 25267489 Detail
0.080 myocardial infarction NA RGD Detail
0.080 Myocardial Reperfusion Injury NA RGD Detail
0.003 Myxoma NA BeFree,LHGDN Detail
0.002 Neoplasm Recurrence, Local NA GAD Detail
<0.001 nervous system disorder NA BeFree Detail
<0.001 Nervous System Neoplasms NA BeFree Detail
0.003 neurilemmoma NA BeFree,LHGDN Detail
0.005 neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.005 neuroblastoma Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlat... BeFree 25622909 Detail
<0.001 acoustic neuroma NA BeFree Detail
0.121 obesity NA BeFree,CTD_human Detail
<0.001 Cartilaginous exostosis For the first time mutation of AKT1 (c.49G > A) gene was detected both in crania... BeFree 25782637 Detail
0.004 osteosarcoma Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteos... BeFree,LHGDN 25695619 Detail
0.013 ovarian carcinoma MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.013 ovarian carcinoma Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree 25216292 Detail
0.013 ovarian carcinoma REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer. BeFree 25337238 Detail
0.013 ovarian carcinoma The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree 25677064 Detail
0.013 ovarian carcinoma Furthermore, overexpression of miR‑338‑3p inhibited phosphorylation of PI3K and ... BeFree 25776272 Detail
0.013 ovarian carcinoma We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is onco... BeFree 25965947 Detail
0.120 Pain NA CTD_human Detail
0.009 Pancreatic Neoplasm Based on analyses of mice, loss of sst2 from pancreatic tissues activates PI3K s... BeFree,LHGDN 25683115 Detail
<0.001 papilloma NA BeFree Detail
0.080 paraplegia NA RGD Detail
0.003 Parkinson disease Thus, in neurodegenerative states such as PD, maintaining the thiol status of cy... BeFree,GAD 24933620 Detail
<0.001 pericardial effusion Using patient-derived tumor cell models isolated from pericardial effusion of HE... BeFree 25157953 Detail
<0.001 pituitary adenoma NA BeFree Detail
<0.001 Pituitary Diseases NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
0.003 polycystic ovary syndrome NA LHGDN Detail
<0.001 polycythemia vera NA BeFree Detail
0.120 Adenomatous Polyposis Coli Phosphorylation of β-catenin at Ser552 via the miR-21-mediated PTEN/AKT axis pla... BeFree,CTD_human 24832083 Detail
<0.001 Precancerous Conditions NA BeFree Detail
0.177 Prostatic Neoplasms NA BeFree,CTD_human,LHGDN Detail
0.003 psoriasis NA BeFree,LHGDN Detail
0.122 Psychoses, Substance-Induced NA CTD_human,GAD Detail
0.002 Psychotic Disorders NA BeFree Detail
<0.001 pulmonary fibrosis Collectively, this study implies a significant fibrogenic induction activity of ... BeFree 26192087 Detail
0.005 Rectal Neoplasms NA GAD Detail
<0.001 retinal degeneration NA BeFree Detail
0.004 retinoblastoma NA BeFree,GAD Detail
<0.001 Rett syndrome NA BeFree Detail
0.005 rhabdomyosarcoma MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R express... BeFree,LHGDN 25427715 Detail
0.005 rhabdomyosarcoma Here, we identify a novel synthetic lethality of concomitant inhibition of HH an... BeFree,LHGDN 25749378 Detail
0.003 Salivary Gland Neoplasms NA LHGDN Detail
<0.001 Kaposi sarcoma NA BeFree Detail
0.253 schizophrenia NA BeFree,CTD_human,GAD,LHGDN,MGD Detail
0.003 systemic scleroderma NA LHGDN Detail
<0.001 Sezary syndrome NA BeFree Detail
<0.001 Shared Paranoid Disorder NA BeFree Detail
<0.001 Skin lesion We have already shown that AKT is activated in skin lesions in Mycosis Fungoides... BeFree 25267489 Detail
0.121 Skin Neoplasms NA BeFree,CTD_human Detail
<0.001 Soft Tissue Neoplasms NA BeFree Detail
0.009 Stomach Neoplasms In two MET-amplified human gastric tumor xenograft models, SNU-5 and Hs 746T, in... BeFree,LHGDN 25504634 Detail
<0.001 Cerebrovascular accident NA BeFree Detail
0.003 Testicular Neoplasms NA BeFree,LHGDN Detail
0.003 thymoma The survival of CSF1R(pos) cells requires active AKT (v-akt murine thymoma viral... BeFree 24722292 Detail
0.003 thymoma Furthermore, we show that ectopically expressed SPINT2 in melanoma cells inhibit... BeFree 25910030 Detail
0.013 Thyroid Neoplasm NA BeFree,GAD,LHGDN Detail
<0.001 tuberculosis NA BeFree Detail
0.003 Tuberculosis, Pulmonary NA BeFree,GAD Detail
0.001 tuberous sclerosis NA BeFree Detail
<0.001 Attention Deficit Disorder NA BeFree Detail
0.080 ureteral obstruction NA RGD Detail
<0.001 Uterine Fibroids In cell culture models of TSC2-deficient LAM patient-derived and rat uterine lei... BeFree 25069840 Detail
0.003 Uterine Neoplasms NA LHGDN Detail
<0.001 Virus Diseases NA BeFree Detail
<0.001 common wart NA BeFree Detail
<0.001 xeroderma pigmentosum NA BeFree Detail
<0.001 Ichthyosis, X-Linked NA BeFree Detail
0.005 B-Cell Lymphomas Many alterations directly or indirectly lead to activation of survival signaling... BeFree,LHGDN 24811162 Detail
0.005 B-Cell Lymphomas TRIM62 loss was associated with altered expression of proteins involved in leuke... BeFree,LHGDN 25248926 Detail
0.005 B-Cell Lymphomas It was previously shown that cyclic AMP (cAMP) induces sensitivity to GCs by inh... BeFree,LHGDN 25576220 Detail
0.005 B-Cell Lymphomas However, there have been preclinical data showing PI3K/AKT pathway activation in... BeFree,LHGDN 25862915 Detail
0.005 B-Cell Lymphomas The absence of Esr2 resulted in increased apoptosis, decreased B-cell lymphoma 2... BeFree,LHGDN 25885794 Detail
0.005 B-Cell Lymphomas Lupalbigenin treatment significantly down-regulated survival proteins, including... BeFree,LHGDN 25964563 Detail
0.003 diffuse large B-cell lymphoma The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of ... BeFree 25215588 Detail
0.003 diffuse large B-cell lymphoma Treatment of DLBCL cells with EtOH suppressed mTORC1 complex formation while inc... BeFree 25849580 Detail
0.003 T-Cell Lymphoma However, there have been preclinical data showing PI3K/AKT pathway activation in... BeFree,LHGDN 25862915 Detail
<0.001 Lymphoma, T-Cell, Cutaneous NA BeFree Detail
<0.001 peripheral T-cell lymphoma The clinical significance of activated p-AKT expression in peripheral T-cell lym... BeFree 25862915 Detail
0.361 Proteus syndrome Proteus syndrome is caused by an activating AKT1 mutation (c.49G>A, p.Glu17Lys). BeFree,CLINVAR,ORPHANET,UNIPROT 23992099 Detail
<0.001 Neurofibrillary degeneration (morphologic abnormality) NA BeFree Detail
0.080 autosomal recessive polycystic kidney disease NA BeFree,RGD Detail
<0.001 Liver failure NA BeFree Detail
0.001 acute leukemia NA BeFree Detail
<0.001 Chronic gastritis NA BeFree Detail
<0.001 benign neoplasm NA BeFree Detail
<0.001 Left Ventricular Hypertrophy NA BeFree Detail
<0.001 Squamous cell carcinoma of lung NA BeFree Detail
0.002 Small cell carcinoma of lung Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as ... BeFree 25122428 Detail
<0.001 Thyroid Gland Follicular Adenoma NA BeFree Detail
<0.001 Atrophic condition of skin NA BeFree Detail
0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 esophageal carcinoma Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophagea... BeFree 25912437 Detail
<0.001 lingual-facial-buccal dyskinesia NA BeFree Detail
<0.001 Idiopathic pulmonary hypertension NA BeFree Detail
<0.001 Non-arthropod borne lymphocytic choriomeningitis Here, we show that during chronic murine lymphocytic choriomeningitis virus infe... BeFree 25464856 Detail
<0.001 Malignant neoplasm of mouth NA BeFree Detail
<0.001 uterine cancer NA BeFree Detail
<0.001 Malignant neoplasm of brain NA BeFree Detail
<0.001 Secondary malignant neoplasm of bone Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor an... BeFree 25623744 Detail
<0.001 Malnutrition NA BeFree Detail
0.080 Right Ventricular Hypertrophy NA RGD Detail
<0.001 LEOPARD Syndrome NA BeFree Detail
<0.001 Agenesis of corpus callosum NA BeFree Detail
0.006 Tumor Progression Therefore, our study addressed a novel role of CIP2A in mediating cancer progres... BeFree 25109354 Detail
0.006 Tumor Progression Elevated levels of extracellular glutamate were observed in mGluR1-expressing br... BeFree 25859923 Detail
0.006 Tumor Progression This review discusses the role of PRAS40 and possible feedback mechanisms, and a... BeFree 26003731 Detail
<0.001 Liposarcoma, Dedifferentiated We found that the in vitro stimulation of DDLPS cells with hepatocyte growth fac... BeFree 26006023 Detail
<0.001 Germ cell tumor FGFR3, AKT1, and PIK3CA mutations are all reported for the first time in GCT. BeFree 24812411 Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kina... BeFree 25961698 Detail
<0.001 hepatoblastoma NA BeFree Detail
<0.001 Mixed Tumor, Mullerian NA BeFree Detail
<0.001 Liposarcoma, Myxoid NA BeFree Detail
<0.001 Rhabdomyosarcoma, Embryonal NA BeFree Detail
<0.001 hepatocellular adenoma NA BeFree Detail
<0.001 Adenocarcinoma, Clear Cell NA BeFree Detail
<0.001 Follicular thyroid carcinoma NA BeFree Detail
0.002 Papillary and follicular adenocarcinoma NA GAD Detail
<0.001 adrenocortical carcinoma NA BeFree Detail
<0.001 Carcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
0.005 cholangiocarcinoma The transposase-mediated transduction of constitutively active AKT and Yes-assoc... BeFree,LHGDN 25580681 Detail
<0.001 Cystadenocarcinoma, Serous REDD1 and p-AKT expressions were significantly higher in serous adenocarcinoma t... BeFree 25337238 Detail
<0.001 Carcinoma, Large Cell NA BeFree Detail
<0.001 gliosarcoma NA BeFree Detail
<0.001 Neuroendocrine Tumors Neuroendocrine cancer cell lines are used to investigate therapeutic targets in ... BeFree 26087898 Detail
<0.001 uveal melanoma NA BeFree Detail
<0.001 Lip and oral cavity carcinoma NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain NA BeFree Detail
<0.001 Mastocytosis, Systemic The present article provides an overview of our current knowledge about the crit... BeFree 24598853 Detail
<0.001 Macrocephaly PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalenc... BeFree 25722288 Detail
<0.001 Psychiatric symptom NA BeFree Detail
0.005 pancreatic carcinoma Two selected anti-AXL mAbs (D9 and E8), which inhibited phosphorylation of AXL a... BeFree 24240689 Detail
0.005 pancreatic carcinoma In conclusion, the present study reveals that the increased expression of OCT4 i... BeFree 25017645 Detail
0.005 pancreatic carcinoma Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree 25071014 Detail
0.005 pancreatic carcinoma GDC-0980 inhibited AKT-mTOR activation and pancreatic cancer cell (PANC-1 and Ca... BeFree 25285629 Detail
0.122 Amphetamine-Related Disorders NA CTD_human,GAD Detail
0.005 Gastrointestinal Stromal Tumors microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imati... BeFree,LHGDN 24706111 Detail
<0.001 Light chain disease NA BeFree Detail
<0.001 Lymphedema praecox NA BeFree Detail
<0.001 Anaplastic thyroid carcinoma NA BeFree Detail
<0.001 Medullary carcinoma of thyroid NA BeFree Detail
0.001 Papillary thyroid carcinoma NA BeFree Detail
0.080 Erectile dysfunction NA RGD Detail
0.019 Malignant neoplasm of lung Suppression of AKT expression by miR-153 produced anti-tumor activity in lung ca... BeFree,GAD 25066607 Detail
0.019 Malignant neoplasm of lung Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1... BeFree,GAD 25662161 Detail
0.019 Malignant neoplasm of lung Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor ME... BeFree,GAD 25697899 Detail
0.019 Malignant neoplasm of lung Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and s... BeFree,GAD 25738369 Detail
0.019 Malignant neoplasm of lung Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 ov... BeFree,GAD 25862855 Detail
<0.001 Multiple tumors NA BeFree Detail
<0.001 Congenital macrodactylia NA BeFree Detail
<0.001 Congenital anomaly of brain PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalenc... BeFree 25722288 Detail
<0.001 polymicrogyria NA BeFree Detail
<0.001 Isovaleryl-CoA dehydrogenase deficiency Guanine nucleotide binding protein alpha13 (GNA13) and protein tyrosine phosphat... BeFree 25193986 Detail
<0.001 Endometrioma NA BeFree Detail
<0.001 Impaired glucose tolerance NA BeFree Detail
<0.001 Stage II Colon Cancer NA BeFree Detail
<0.001 Malignant neoplasm of colon stage IV NA BeFree Detail
<0.001 Carcinoma breast stage IV NA BeFree Detail
<0.001 Cervix carcinoma recurrent Activated PI3K/AKT/mTOR pathway frequently occurs in metastatic or recurrent cer... BeFree 25426553 Detail
<0.001 inflammatory breast carcinoma Eighty-nine cases of pure high-grade DCIS and 119 cases of high-grade DCIS assoc... BeFree 24634376 Detail
<0.001 Metastatic melanoma Introduction of RASSF6 into a B-Raf(V600E)-containing metastatic melanoma cell l... BeFree 25482183 Detail
<0.001 Cancer of Head and Neck NA BeFree Detail
0.002 Liver and Intrahepatic Biliary Tract Carcinoma The rGEP was shown to trigger phosphorylation of AKT and ERK1/2 in liver cancer ... BeFree 25115442 Detail
0.002 Liver and Intrahepatic Biliary Tract Carcinoma As a trigger of Rac GTPase signaling after G protein-coupled receptors (GPCR) ac... BeFree 25151370 Detail
<0.001 Invasive lobular breast carcinoma PTEN loss associated with increased AKT phosphorylation, which was highest in IL... BeFree 26451490 Detail
0.002 Squamous cell carcinoma of esophagus Taken together, our results suggest a novel and critical role of TIP30 involved ... BeFree 25544767 Detail
0.002 Squamous cell carcinoma of esophagus It was tested using an AKT shRNA knockdown of ESCC cell lines and the in vivo tu... BeFree 25834829 Detail
0.002 Squamous cell carcinoma of esophagus Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carci... BeFree 25843419 Detail
<0.001 Serous cystadenocarcinoma ovary NA BeFree Detail
<0.001 cervical squamous cell carcinoma The objective of this study was to investigate the predictive value of common ge... BeFree 25773678 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Both decreased MLH1 and increased AKT levels induced lower PMS2, indicating that... BeFree 25528216 Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma Increased activity of PI3K/AKT/PMS2 could play a role in SETD2 mutated ccRCC. BeFree 26537074 Detail
<0.001 Solid tumour Impaired fatty acid synthesis was associated with reduced solid tumor cell proli... BeFree 25472762 Detail
<0.001 Acute Undifferentiated Leukemia TRIM62 loss was associated with altered expression of proteins involved in leuke... BeFree 25248926 Detail
<0.001 stage, non-small cell lung cancer NA BeFree Detail
<0.001 Squamous cell carcinoma of oropharynx PIK3CA mutations are more common in HPV(+) OPSCC and are associated with activat... BeFree 24599934 Detail
<0.001 Squamous cell carcinoma of oropharynx Taken together, our study points to a critical role of MYBBP1A in the regulation... BeFree 25543088 Detail
<0.001 laryngeal squamous cell carcinoma Ectopic transfection of miR-375 led to a significant reduction in IGF1R and its ... BeFree 25184138 Detail
<0.001 Adenocarcinoma of pancreas NA BeFree Detail
<0.001 Prostatic Intraepithelial Neoplasias NA BeFree Detail
0.002 cervix carcinoma Additionally, treatment with butein significantly increased reactive oxygen spec... BeFree 25962638 Detail
0.003 Atrophic NA LHGDN Detail
<0.001 High-Grade Squamous Intraepithelial Lesions NA BeFree Detail
<0.001 anaplastic astrocytoma NA BeFree Detail
<0.001 pilocytic astrocytoma NA BeFree Detail
0.005 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse NA BeFree,LHGDN Detail
<0.001 Impaired cognition NA BeFree Detail
<0.001 Congenital neutropenia Similarly, high-dose G-CSF (or downstream signaling through AKT/BCL2) rescues th... BeFree 26193632 Detail
<0.001 Acute retention of urine NA BeFree Detail
<0.001 Malonic aciduria NA BeFree Detail
0.002 Malignant neoplasm of liver The rGEP was shown to trigger phosphorylation of AKT and ERK1/2 in liver cancer ... BeFree 25115442 Detail
0.002 Malignant neoplasm of liver As a trigger of Rac GTPase signaling after G protein-coupled receptors (GPCR) ac... BeFree 25151370 Detail
<0.001 intrahepatic cholangiocarcinoma NA BeFree Detail
<0.001 malignant mesothelioma These findings suggest that NK4 acts as a CSC inhibitor by impeding Met/AKT/β-ca... BeFree 25501304 Detail
<0.001 ovarian cystadenoma NA BeFree Detail
<0.001 Vulval intraepithelial neoplasia NA BeFree Detail
0.005 Malignant neoplasm of pancreas Two selected anti-AXL mAbs (D9 and E8), which inhibited phosphorylation of AXL a... BeFree 24240689 Detail
0.005 Malignant neoplasm of pancreas In conclusion, the present study reveals that the increased expression of OCT4 i... BeFree 25017645 Detail
0.005 Malignant neoplasm of pancreas Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree 25071014 Detail
0.005 Malignant neoplasm of pancreas GDC-0980 inhibited AKT-mTOR activation and pancreatic cancer cell (PANC-1 and Ca... BeFree 25285629 Detail
0.001 Nonorganic psychosis NA BeFree Detail
<0.001 Depressive episode, unspecified Decreases in blood AKT1 and mTOR mRNA expression, as well as in BAD/BCL-2 expres... BeFree 25726893 Detail
<0.001 Carcinoma of anal margin NA BeFree Detail
<0.001 Squamous cell carcinoma of tongue miR-29b functions as a tumor suppressor in TSCC, and the miR-29b/Sp1/PTEN/AKT ax... BeFree 25127200 Detail
<0.001 Splenic Marginal Zone B-Cell Lymphoma NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance... BeFree 24469048 Detail
<0.001 Ischemic cardiomyopathy NA BeFree Detail
<0.001 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site NA BeFree Detail
0.018 Malignant neoplasm of prostate Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumo... BeFree,GAD 24838891 Detail
0.018 Malignant neoplasm of prostate Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α v... BeFree,GAD 25026288 Detail
0.018 Malignant neoplasm of prostate Complex impacts of PI3K/AKT inhibitors to androgen receptor gene expression in p... BeFree,GAD 25360799 Detail
0.018 Malignant neoplasm of prostate Our findings offer new insight in the regulation of the PTEN/AKT pathway and pro... BeFree,GAD 25728608 Detail
0.018 Malignant neoplasm of prostate MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate ... BeFree,GAD 25922934 Detail
<0.001 Hematopoietic Neoplasms NA BeFree Detail
<0.001 Hematologic Neoplasms NA BeFree Detail
<0.001 Lhermitte-Duclos disease NA BeFree Detail
<0.001 Lymphatic Abnormalities The activation of a central growth/survival pathway (PI3K/AKT) represents a feas... BeFree 25292196 Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Congenital bilateral aplasia of vas deferens NA BeFree Detail
0.120 Aortic valve calcification NA CTD_human Detail
<0.001 Cortical Dysplasia PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalenc... BeFree 25722288 Detail
<0.001 Hemimegalencephaly The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is... BeFree 25451314 Detail
<0.001 Endometrioid tumor Endometrial cancers have been recently molecularly characterized; amplifications... BeFree 24820961 Detail
<0.001 Papillary neoplasm NA BeFree Detail
0.009 endometrial carcinoma The effect of estrogen on the proliferation of endometrial cancer cells is media... BeFree 25068805 Detail
0.009 endometrial carcinoma This review will focus on the role of AKT in the uterus and its function in proc... BeFree 25118299 Detail
0.009 endometrial carcinoma Targeting key signaling components of PI3K/AKT pathway by restoring or inhibitin... BeFree 25141911 Detail
<0.001 Secondary malignant neoplasm of liver NA BeFree Detail
<0.001 dementia NA BeFree Detail
<0.001 Benign neurologic neoplasms NA BeFree Detail
<0.001 Recurrent tumor NA BeFree Detail
<0.001 Increased drug resistance NA BeFree Detail
0.003 Metabolic syndrome X NA BeFree,GAD Detail
0.002 Retinal Neoplasms NA GAD Detail
<0.001 Neurodegenerative Disorders Critical cysteines in Akt1 regulate its activity and proteasomal degradation: im... BeFree 24933620 Detail
<0.001 Mood Disorders NA BeFree Detail
0.003 Malignant neoplasm of esophagus In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathw... BeFree,GAD 25912437 Detail
<0.001 X-Linked Lymphoproliferative Disorder Intrinsic defect in B-lymphoblastoid cell lines from patients with X-linked lymp... BeFree 25265348 Detail
0.004 Thyroid carcinoma NA BeFree Detail
<0.001 Ewings sarcoma NA BeFree Detail
<0.001 Oropharyngeal disorders We identified frequent PIK3CA mutations in patients with high-risk HNSCC confine... BeFree 23852799 Detail
<0.001 Malignant glioma NA BeFree Detail
<0.001 Osteosarcoma of bone Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteos... BeFree 25695619 Detail
<0.001 Costello syndrome (disorder) NA BeFree Detail
0.031 Carcinogenesis Together, these observations suggest that STAT5 and AKT are key drivers of oncog... BeFree 24598853 Detail
0.031 Carcinogenesis Akt1 has an important role in lung carcinogenesis, and depletion of Akt1 has bee... BeFree 24658401 Detail
0.031 Carcinogenesis MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis... BeFree 25074979 Detail
0.031 Carcinogenesis Overexpression of miR-320a led to the inhibition of cell proliferation, migratio... BeFree 25117070 Detail
0.031 Carcinogenesis Functional analyses revealed their contribution to prostate carcinogenesis by ta... BeFree 25153594 Detail
0.031 Carcinogenesis The activation of AKT often contributes to tumorigenesis and plays a role in reg... BeFree 25270272 Detail
0.031 Carcinogenesis In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AK... BeFree 25288334 Detail
0.031 Carcinogenesis In summary, AR overexpression induced by AKT phosphorylation upregulated MMP9 by... BeFree 25301736 Detail
0.031 Carcinogenesis Then, miRNA-regulated protein interaction network was constructed and 5 topologi... BeFree 25424347 Detail
0.031 Carcinogenesis The transposase-mediated transduction of constitutively active AKT and Yes-assoc... BeFree 25580681 Detail
0.031 Carcinogenesis Our results demonstrate a central role of miR-22 in the physiologic regulation o... BeFree 25627978 Detail
0.031 Carcinogenesis Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathw... BeFree 25654238 Detail
0.031 Carcinogenesis Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 ov... BeFree 25862855 Detail
0.031 Carcinogenesis The interconnected Ras/ERK and PI3K/AKT pathways play a central role in colorect... BeFree 25889965 Detail
<0.001 Leukemogenesis We then performed in vivo experiments and found that the Id1 inhibitor significa... BeFree 26084673 Detail
0.016 prostate carcinoma Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumo... BeFree 24838891 Detail
0.016 prostate carcinoma Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α v... BeFree 25026288 Detail
0.016 prostate carcinoma Complex impacts of PI3K/AKT inhibitors to androgen receptor gene expression in p... BeFree 25360799 Detail
0.016 prostate carcinoma Our findings offer new insight in the regulation of the PTEN/AKT pathway and pro... BeFree 25728608 Detail
0.016 prostate carcinoma MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate ... BeFree 25922934 Detail
0.002 hepatopulmonary syndrome NA GAD Detail
0.005 Epithelial ovarian cancer Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. BeFree 25216292 Detail
0.005 Epithelial ovarian cancer We established that amplifications in 14q32.33 were associated with reduced OS, ... BeFree 25281495 Detail
0.005 Epithelial ovarian cancer Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pat... BeFree 25307974 Detail
0.005 Epithelial ovarian cancer CXCR7 signaling induced epithelial-mesenchymal transition by AKT and ERK pathway... BeFree 25359618 Detail
0.005 Epithelial ovarian cancer Rab25 is responsible for phosphoinositide 3-kinase/AKT‑mediated cisplatin resist... BeFree 25405658 Detail
<0.001 invasive cancer NA BeFree Detail
<0.001 Refractory cancer NA BeFree Detail
0.030 breast carcinoma As expected, rapamycin inhibition of mTOR results in feedback activation of AKT ... BeFree 25023728 Detail
0.030 breast carcinoma MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis... BeFree 25074979 Detail
0.030 breast carcinoma In this study, germline SNPs in the PI3 K-AKT-mTOR pathway were associated with ... BeFree 25108739 Detail
0.030 breast carcinoma The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 1... BeFree 25283550 Detail
0.030 breast carcinoma A significant reduction in post-relapse breast cancer-specific survival was asso... BeFree 25361981 Detail
0.030 breast carcinoma Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with c... BeFree 25422220 Detail
0.030 breast carcinoma Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been... BeFree 25491778 Detail
0.030 breast carcinoma Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluore... BeFree 25702787 Detail
0.030 breast carcinoma RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitr... BeFree 25953046 Detail
0.030 breast carcinoma Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is ... BeFree 26247526 Detail
0.030 breast carcinoma Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which ... BeFree 26267533 Detail
0.030 breast carcinoma This study provides a novel treatment strategy that PI3K/AKT/mTOR pathway inhibi... BeFree 26427150 Detail
0.009 Carcinoma of lung Suppression of AKT expression by miR-153 produced anti-tumor activity in lung ca... BeFree 25066607 Detail
0.009 Carcinoma of lung Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1... BeFree 25662161 Detail
0.009 Carcinoma of lung Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor ME... BeFree 25697899 Detail
0.009 Carcinoma of lung Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and s... BeFree 25738369 Detail
0.009 Carcinoma of lung Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 ov... BeFree 25862855 Detail
<0.001 Tardive Dyskinesia NA BeFree Detail
0.125 colon carcinoma In the present study, the expression status of miR-218 and the role of the phosp... BeFree,CLINVAR 25760926 Detail
0.125 colon carcinoma Thereby, PTEN/PI3K/AKT/NF-κB/paxillin signaling cascade is an attractive therape... BeFree,CLINVAR 25873394 Detail
0.125 colon carcinoma Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree,CLINVAR 25889965 Detail
0.010 stomach carcinoma IL-32 contributes to gastric cancer progression by increasing the metastatic pot... BeFree 24602839 Detail
0.010 stomach carcinoma Disruption of EGFL7-EGFR-AKT-Snail signaling may a promising therapeutic strateg... BeFree 24945379 Detail
0.010 stomach carcinoma In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a nov... BeFree 25015565 Detail
0.010 stomach carcinoma Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38M... BeFree 25150310 Detail
0.010 stomach carcinoma In this review, a basic overview of the role of AKT in normal and malignant tiss... BeFree 25270272 Detail
0.010 stomach carcinoma In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AK... BeFree 25288334 Detail
0.010 stomach carcinoma The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a no... BeFree 25301736 Detail
0.010 stomach carcinoma ECHS1 may play important roles in gastric cancer cell proliferation and migratio... BeFree 25338767 Detail
0.010 stomach carcinoma Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased e... BeFree 25394504 Detail
0.010 stomach carcinoma In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosi... BeFree 25395073 Detail
0.010 stomach carcinoma MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in g... BeFree 25400827 Detail
0.010 stomach carcinoma Our studies revealed that miR-29s expression is downregulated in GC and they cou... BeFree 25428377 Detail
0.010 stomach carcinoma Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT ... BeFree 25448881 Detail
0.010 stomach carcinoma MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in g... BeFree 25914465 Detail
0.005 Carcinoma of bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree 24929024 Detail
0.005 Carcinoma of bladder Naringenin inhibits migration of bladder cancer cells through downregulation of ... BeFree 25017119 Detail
0.005 Carcinoma of bladder Mechanism studies suggest that ERα could control the expression of INPP4B to red... BeFree 25277204 Detail
0.005 Carcinoma of bladder Taken together, these findings highlight for the first time that ANG could play ... BeFree 25564356 Detail
<0.001 skin carcinoma NA BeFree Detail
0.004 Central neuroblastoma Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combinati... BeFree 25228590 Detail
0.004 Central neuroblastoma Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlat... BeFree 25622909 Detail
<0.001 bile duct carcinoma NA BeFree Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 biliary tract cancer Western blotting results showed the p-p70S6K, p-Gli1, p-mTOR, and p-AKT protein ... BeFree 25742482 Detail
<0.001 malignant pleural mesothelioma The above observation was further substantiated by the finding that a majority o... BeFree 25221930 Detail
<0.001 Oestrogen deficiency NA BeFree Detail
<0.001 Invasive breast carcinoma NA BeFree Detail
<0.001 Recurrent Chronic Lymphoid Leukemia NA BeFree Detail
0.001 Rhabdoid Tumor of the Kidney NA BeFree Detail
<0.001 Endothelial dysfunction NA BeFree Detail
<0.001 Advanced cancer NA BeFree Detail
<0.001 Intraepithelial Neoplasia NA BeFree Detail
0.120 Cardiomyopathies NA BeFree,CTD_human Detail
<0.001 Erdheim-Chester disease NA BeFree Detail
<0.001 Metastatic Prostate Carcinoma NA BeFree Detail
<0.001 Vascular inflammations NA BeFree Detail
<0.001 Acute coronary syndrome NA BeFree Detail
<0.001 Colorectal cancer metastatic NA BeFree Detail
<0.001 Tauopathies The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is... BeFree 25451314 Detail
0.080 Arthritis, Experimental NA RGD Detail
<0.001 Drug Resistant Epilepsy In this study we performed multiplex targeted sequencing of 10 genes in the PI3K... BeFree 25722288 Detail
0.012 Malignant neoplasm of ovary MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth fa... BeFree 25176450 Detail
0.012 Malignant neoplasm of ovary REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer. BeFree 25337238 Detail
0.012 Malignant neoplasm of ovary The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. BeFree 25677064 Detail
0.012 Malignant neoplasm of ovary Furthermore, overexpression of miR‑338‑3p inhibited phosphorylation of PI3K and ... BeFree 25776272 Detail
0.012 Malignant neoplasm of ovary We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is onco... BeFree 25965947 Detail
0.004 Squamous cell carcinoma of the head and neck Two HNSCC and a control keratinocyte cell lines were treated with EGF and wortma... BeFree 23730900 Detail
0.004 Squamous cell carcinoma of the head and neck We identified frequent PIK3CA mutations in patients with high-risk HNSCC confine... BeFree 23852799 Detail
0.004 Squamous cell carcinoma of the head and neck PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients ... BeFree 24421178 Detail
0.004 Squamous cell carcinoma of the head and neck Likewise, we examined the activation of the PI3K/AKT/mTOR pathway in HNSCC tumor... BeFree 25193510 Detail
0.004 Squamous cell carcinoma of the head and neck Enhanced expression of sprouty2 protein suppressed the growth of HNSCC cells and... BeFree 25333206 Detail
0.003 Ductal Carcinoma NA BeFree,LHGDN Detail
<0.001 Aortic valve disorder NA BeFree Detail
<0.001 Central odontogenic fibroma For the first time mutation of AKT1 (c.49G > A) gene was detected both in crania... BeFree 25782637 Detail
0.002 sarcoma IR-induced cell death was also associated with downregulation of v-src sarcoma (... BeFree 25273173 Detail
<0.001 attention deficit hyperactivity disorder NA BeFree Detail
<0.001 Collecting Duct Carcinoma of the Kidney NA BeFree Detail
<0.001 Solitary fibrous tumor Immunohistochemical staining for PDGFα; PDGFβ; PDGFR-α; PDGFR-β; IGF1R; EGFR; VE... BeFree 25976141 Detail
<0.001 Atypical teratoid/rhabdoid tumor NA BeFree Detail
0.002 major depressive disorder NA GAD Detail
<0.001 Mediastinal (Thymic) Large B-Cell Lymphoma NA BeFree Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Dental cyst Proteus syndrome: Report of a case with AKT1 mutation in a dental cyst. BeFree 25782637 Detail
<0.001 Squamous cell carcinoma of pharynx NA BeFree Detail
<0.001 Hormone refractory prostate cancer NA BeFree Detail
<0.001 Atypical Ductal Breast Hyperplasia NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
<0.001 mesenchymal cell neoplasm NA BeFree Detail
0.002 Necrotic changes (finding) NA GAD Detail
<0.001 Osteogenic Neoplasm NA BeFree Detail
<0.001 pancreatic ductal adenocarcinoma In conclusion, SELP and AKT1 polymorphisms may play a role in the risk of cachex... BeFree 25238546 Detail
<0.001 Testicular Germ Cell Tumor NA BeFree Detail
<0.001 Epithelioma NA BeFree Detail
<0.001 Liposarcoma, well differentiated NA BeFree Detail
<0.001 Undifferentiated leukemia TRIM62 loss was associated with altered expression of proteins involved in leuke... BeFree 25248926 Detail
<0.001 renal carcinoma NA BeFree Detail
<0.001 Metastatic Carcinoma Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase ... BeFree 25426553 Detail
<0.001 anal squamous cell carcinoma NA BeFree Detail
0.002 Methamphetamine abuse NA GAD Detail
0.175 Mammary Neoplasms Regulation of AKT by BRCA1 in both our cell model and BRCA1-mutated breast tumor... BeFree,CTD_human,GAD,LHGDN 25010005 Detail
0.175 Mammary Neoplasms Future studies are needed to replicate our results and to evaluate the relations... BeFree,CTD_human,GAD,LHGDN 25108739 Detail
0.175 Mammary Neoplasms In addition, inhibitors to the AKT/IGF-1R signaling pathways may provide alterna... BeFree,CTD_human,GAD,LHGDN 25178514 Detail
<0.001 Breast Cancer Model NA BeFree Detail
0.001 Hepatocarcinogenesis Altogether, the present data indicate that SKP2 cooperates with N-Ras and AKT pr... BeFree 25537506 Detail
0.001 Hepatocarcinogenesis Noticeably, miR-375 showed limited antineoplastic activity against c-Myc driven ... BeFree 25762642 Detail
<0.001 Chronic Lymphoproliferative Disorder of NK-Cells NA BeFree Detail
<0.001 Mammary Tumorigenesis These findings establish ShcA as a biological bridge that links AKT activation d... BeFree 24837366 Detail
0.001 Cancer Cell Growth NA BeFree Detail
<0.001 Skin Carcinogenesis NA BeFree Detail
0.001 Tumor Angiogenesis NA BeFree Detail
<0.001 Tumor Expansion NA BeFree Detail
<0.001 Tumor Immunity NA BeFree Detail
<0.001 Xenograft Model Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF ... BeFree 25071014 Detail
0.012 colorectal cancer The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K... BeFree,GAD 24666267 Detail
0.012 colorectal cancer Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits const... BeFree,GAD 25365190 Detail
0.012 colorectal cancer Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer. BeFree,GAD 25374184 Detail
0.012 colorectal cancer Portrait of the PI3K/AKT pathway in colorectal cancer. BeFree,GAD 25450577 Detail
0.012 colorectal cancer Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation ... BeFree,GAD 25800793 Detail
0.012 colorectal cancer We analyzed the mutation spectra of the PI3K/PTEN/AKT and RAS/RAF/MAPK pathways ... BeFree,GAD 25920435 Detail
0.001 Non-Malignant Ascites Adverse Event NA BeFree Detail
<0.001 Adenocarcinoma, Endometrioid Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is freq... BeFree 25677064 Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 Macular dystrophy, corneal type 1 NA BeFree Detail
<0.001 androgen independent prostate cancer NA BeFree Detail
<0.001 Milroy Disease NA BeFree Detail
<0.001 Invasive Skin Melanoma NA BeFree Detail
<0.001 Meningioma, benign, no ICD-O subtype Inhibition of TGM2 function by siRNA or cystamine induced meningioma cell death,... BeFree 25247996 Detail
<0.001 Meningioma, benign, no ICD-O subtype The recent identification of somatic mutations in components of the SHH-GLI1 and... BeFree 25857641 Detail
<0.001 Progesterone Resistance NA BeFree Detail
<0.001 severe congenital neutropenia Similarly, high-dose G-CSF (or downstream signaling through AKT/BCL2) rescues th... BeFree 26193632 Detail
<0.001 Prostate Cancer, Hereditary, 7 NA BeFree Detail
<0.001 TUBEROUS SCLEROSIS 2 (disorder) In cell culture models of TSC2-deficient LAM patient-derived and rat uterine lei... BeFree 25069840 Detail
<0.001 AMYOTROPHIC LATERAL SCLEROSIS 1 NA BeFree Detail
<0.001 Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome NA BeFree Detail
<0.001 SCHIZOPHRENIA 8 (disorder) NA BeFree Detail
<0.001 ALZHEIMER DISEASE 5 NA BeFree Detail
0.006 uterine corpus cancer The effect of estrogen on the proliferation of endometrial cancer cells is media... BeFree 25068805 Detail
0.006 uterine corpus cancer This review will focus on the role of AKT in the uterus and its function in proc... BeFree 25118299 Detail
0.006 uterine corpus cancer Targeting key signaling components of PI3K/AKT pathway by restoring or inhibitin... BeFree 25141911 Detail
<0.001 Carcinoma Metastatic to the Skin NA BeFree Detail
<0.001 Leukemia, Natural Killer Cell Large Granular Lymphocytic NA BeFree Detail
<0.001 coronary artery disease NA BeFree Detail
<0.001 PTEN hamartoma tumor syndrome NA BeFree Detail
0.005 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma We also explored the molecular mechanism of FHL1C overexpression-induced apoptos... BeFree,GAD 24952875 Detail
0.005 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Although high mTORC2-AKT activation is commonly associated with drug-resistance,... BeFree,GAD 25241901 Detail
0.005 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Using a focused chemical genomic approach, we demonstrate that xenografted cell ... BeFree,GAD 25281505 Detail
0.005 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma PTEN and NOTCH1 mutations were almost mutually exclusive, while IL7R and WT1 mut... BeFree,GAD 26341754 Detail
<0.001 low grade glioma We previously demonstrated that TMZ treatment of LGG induces driver mutations in... BeFree 25724300 Detail
0.001 Urothelial Carcinoma NA BeFree Detail
0.014 liver carcinoma The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signa... BeFree 24970807 Detail
0.014 liver carcinoma In the present study, we report a novel insulin-like growth factor 1 (IGF1) path... BeFree 25420499 Detail
0.014 liver carcinoma The newly identified miR-149/AKT/mTOR axis might be a promising therapeutic targ... BeFree 25424347 Detail
0.014 liver carcinoma The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which wou... BeFree 25617127 Detail
0.014 liver carcinoma The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/m... BeFree 25778319 Detail
0.014 liver carcinoma Depletion of DUOX2 abrogated PKCα-induced activation of AKT/MAPK pathways as wel... BeFree 26056003 Detail
0.014 liver carcinoma LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negativ... BeFree 26249360 Detail
<0.001 Oropharyngeal Carcinoma Because of the frequent PIK3CA and AKT1 mutations in patients with oropharyngeal... BeFree 23852799 Detail
0.120 Breast-ovarian cancer, familial, susceptibility to, 1 NA CTD_human Detail
<0.001 Steatohepatitis NA BeFree Detail
<0.001 Macroencephaly PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalenc... BeFree 25722288 Detail
0.004 Nasopharyngeal carcinoma Furthermore, restoration of INPP4B expression significantly suppressed PI3K/AKT ... BeFree 25126743 Detail
0.004 Nasopharyngeal carcinoma Reduced PTEN and PPP2R2B expression correlated with activated AKT/mTOR and PDK1/... BeFree 25762617 Detail
<0.001 Clear-cell metastatic renal cell carcinoma NA BeFree Detail
<0.001 limb ischemia NA BeFree Detail
<0.001 Pulmonary arterial hypertension NA BeFree Detail
<0.001 Early-Stage Breast Carcinoma NA BeFree Detail
<0.001 Stage II Colon Cancer AJCC v7 NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis NA BeFree Detail
<0.001 Roux-en-y Anastomosis Site NA BeFree Detail
0.003 myelodysplastic syndrome NA LHGDN Detail
0.001 Triple Negative Breast Neoplasms KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-... BeFree 24784001 Detail
0.001 Triple Negative Breast Neoplasms Different targeted therapies may be necessary for TNBC that involves activation ... BeFree 25009009 Detail
0.001 Triple Negative Breast Neoplasms Our findings suggest that SPHK1 inhibition, which effectively counteracts oncoge... BeFree 25153718 Detail
0.005 Infection NA LHGDN Detail
<0.001 intellectual disability Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X synd... BeFree 24563264 Detail
<0.001 Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia NA BeFree Detail
<0.001 ESTROGEN RESISTANCE Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been... BeFree 25491778 Detail
<0.001 Experimental Organism Basal Cell Carcinoma NA BeFree Detail
0.008 adenocarcinoma The small interfering RNA (siRNA) was used to suppress CrkL in serous papillary ... BeFree,LHGDN 25307974 Detail
0.005 papillary adenocarcinoma NA GAD Detail
0.003 adenoma NA BeFree,LHGDN Detail
<0.001 Adenovirus Infections NA BeFree Detail
0.002 Alzheimer's disease NA GAD Detail
0.003 ameloblastoma NA BeFree,LHGDN Detail
<0.001 amyotrophic lateral sclerosis NA BeFree Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 Anemia, Sickle Cell NA BeFree Detail
0.005 Anoxia NA LHGDN Detail
<0.001 aortic valve stenosis NA BeFree Detail
<0.001 arteriosclerosis NA BeFree Detail
<0.001 arthritis NA BeFree Detail
0.001 rheumatoid arthritis Our findings identify JNK-dependent modulation of mRNA stability as an important... BeFree 24812285 Detail
0.001 rheumatoid arthritis These results suggest that using SPRY2 to block the AKT and ERK pathways suppres... BeFree 26265114 Detail
0.005 Astrocytoma MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Huma... BeFree,LHGDN 26286747 Detail
0.003 ataxia telangiectasia NA LHGDN Detail
0.006 atherosclerosis NA BeFree,GAD,LHGDN Detail
<0.001 autistic disorder NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
0.003 Bacterial Infections NA LHGDN Detail
<0.001 Mental disorders Overall, the results reinforce a role for AKT1 and mTOR in the pathophysiology o... BeFree 25726893 Detail
0.004 bipolar disorder Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder. BeFree,GAD 25726893 Detail
0.007 Malignant neoplasm of urinary bladder Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential us... BeFree,GAD 24929024 Detail
0.007 Malignant neoplasm of urinary bladder Naringenin inhibits migration of bladder cancer cells through downregulation of ... BeFree,GAD 25017119 Detail
0.007 Malignant neoplasm of urinary bladder Mechanism studies suggest that ERα could control the expression of INPP4B to red... BeFree,GAD 25277204 Detail
0.007 Malignant neoplasm of urinary bladder Taken together, these findings highlight for the first time that ANG could play ... BeFree,GAD 25564356 Detail
<0.001 bladder neck obstruction NA BeFree Detail
<0.001 Bone neoplasms NA BeFree Detail
<0.001 borderline personality disorder NA BeFree Detail
0.003 Brain Neoplasms NA BeFree,LHGDN Detail
0.150 Malignant neoplasm of breast As expected, rapamycin inhibition of mTOR results in feedback activation of AKT ... BeFree,UNIPROT 25023728 Detail
0.150 Malignant neoplasm of breast MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis... BeFree,UNIPROT 25074979 Detail
0.150 Malignant neoplasm of breast In this study, germline SNPs in the PI3 K-AKT-mTOR pathway were associated with ... BeFree,UNIPROT 25108739 Detail
0.150 Malignant neoplasm of breast The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 1... BeFree,UNIPROT 25283550 Detail
0.150 Malignant neoplasm of breast A significant reduction in post-relapse breast cancer-specific survival was asso... BeFree,UNIPROT 25361981 Detail
0.150 Malignant neoplasm of breast Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with c... BeFree,UNIPROT 25422220 Detail
0.150 Malignant neoplasm of breast Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been... BeFree,UNIPROT 25491778 Detail
0.150 Malignant neoplasm of breast Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluore... BeFree,UNIPROT 25702787 Detail
0.150 Malignant neoplasm of breast RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitr... BeFree,UNIPROT 25953046 Detail
0.150 Malignant neoplasm of breast Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is ... BeFree,UNIPROT 26247526 Detail
0.150 Malignant neoplasm of breast Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which ... BeFree,UNIPROT 26267533 Detail
0.150 Malignant neoplasm of breast This study provides a novel treatment strategy that PI3K/AKT/mTOR pathway inhibi... BeFree,UNIPROT 26427150 Detail
<0.001 bronchopulmonary dysplasia NA BeFree Detail
0.003 Burkitt lymphoma NA LHGDN Detail
<0.001 Cachexia AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreati... BeFree 25238546 Detail
0.005 Malignant tumor of colon In the present study, the expression status of miR-218 and the role of the phosp... BeFree 25760926 Detail
0.005 Malignant tumor of colon Thereby, PTEN/PI3K/AKT/NF-κB/paxillin signaling cascade is an attractive therape... BeFree 25873394 Detail
0.005 Malignant tumor of colon Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway gene... BeFree 25889965 Detail
0.006 Malignant neoplasm of endometrium The effect of estrogen on the proliferation of endometrial cancer cells is media... BeFree 25068805 Detail
0.006 Malignant neoplasm of endometrium This review will focus on the role of AKT in the uterus and its function in proc... BeFree 25118299 Detail
0.006 Malignant neoplasm of endometrium Targeting key signaling components of PI3K/AKT pathway by restoring or inhibitin... BeFree 25141911 Detail
<0.001 Adenocarcinoma of prostate NA BeFree Detail
<0.001 Rectal Carcinoma Using a database of 735 colon and rectal cancers in the Nurse's Health Study and... BeFree 25023548 Detail
<0.001 Malignant neoplasm of skin NA BeFree Detail
0.003 Malignant neoplasm of thyroid NA BeFree Detail
<0.001 Bronchioloalveolar Adenocarcinoma NA BeFree Detail
<0.001 Bronchogenic Carcinoma NA BeFree Detail
0.003 Noninfiltrating Intraductal Carcinoma Eighty-nine cases of pure high-grade DCIS and 119 cases of high-grade DCIS assoc... BeFree,LHGDN 24634376 Detail
<0.001 Merkel cell carcinoma NA BeFree Detail
0.015 Non-small cell lung carcinoma Combining AKT inhibition with chloroquine and gefitinib prevents compensatory au... BeFree 24946858 Detail
0.015 Non-small cell lung carcinoma AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib a... BeFree 24957682 Detail
0.015 Non-small cell lung carcinoma Therefore, the AKT inhibitor perifosine might potentially overcome the resistanc... BeFree 24998847 Detail
0.015 Non-small cell lung carcinoma Next, we discovered that LMO1 promoted cancer cell proliferation in our in vitro... BeFree 25037573 Detail
0.015 Non-small cell lung carcinoma Restored the expression of AKT1 partially abolished the suppressive effects miR-... BeFree 25187230 Detail
0.015 Non-small cell lung carcinoma These results suggested that miR-548l may play a causal role through AKT1 in NSC... BeFree 25245053 Detail
0.015 Non-small cell lung carcinoma Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell... BeFree 25323938 Detail
0.015 Non-small cell lung carcinoma Inhibition of the AKT pathway attenuated the biological functions of NSCLC cells... BeFree 25529771 Detail
0.015 Non-small cell lung carcinoma However, the role of ERK1/2 and AKT-mediated XRCC1 expression in gefitinib alone... BeFree 25662161 Detail
0.015 Non-small cell lung carcinoma In addition to selective inhibitors of ERK1/2, AKT, IKBα and NF-κβ, as therapeut... BeFree 26104294 Detail
0.015 Non-small cell lung carcinoma ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expr... BeFree 26149216 Detail
0.002 Carcinoma, Papillary NA GAD Detail
0.006 renal cell carcinoma We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (incl... BeFree,LHGDN 24767687 Detail
0.006 renal cell carcinoma Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor an... BeFree,LHGDN 25623744 Detail
0.006 renal cell carcinoma The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been ide... BeFree,LHGDN 25757764 Detail
Annotation

Annotations

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Additionally, treatment with butein significantly increased reactive oxygen species (ROS) generation... DisGeNET Detail
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In acute myeloid leukemia (AML), several signaling pathways such as the phosphatidylinositol-3-kinas... DisGeNET Detail
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The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways i... DisGeNET Detail
Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated ... DisGeNET Detail
Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer. DisGeNET Detail
Portrait of the PI3K/AKT pathway in colorectal cancer. DisGeNET Detail
Rare mutations not typically associated with CRC included AKT1 (4), AKT2 (1), IDH1 (1), KIT (1), MAP... DisGeNET Detail
Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell prolifer... DisGeNET Detail
We analyzed the mutation spectra of the PI3K/PTEN/AKT and RAS/RAF/MAPK pathways in colorectal cancer... DisGeNET Detail
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However, the changes in AKT1 expression after lithium treatment were positively correlated with depr... DisGeNET Detail
However, the changes in AKT1 expression after lithium treatment were positively correlated with depr... DisGeNET Detail
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In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathway in esophageal can... DisGeNET Detail
For the first time mutation of AKT1 (c.49G > A) gene was detected both in cranial exostosis and in c... DisGeNET Detail
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Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X syndrome (FXS) and intel... DisGeNET Detail
AKT pathway genes define 5 prognostic subgroups in glioblastoma. DisGeNET Detail
Targeting p-Hsp27 and/or p-AKT may be a potential effective strategy for the treatment of glioblasto... DisGeNET Detail
Application of a specific extracellular-related kinase 1/2 (ERK1/2) inhibitor, but not application o... DisGeNET Detail
However, due to the development of resistance mechanisms, kinase inhibition studies targeting the PI... DisGeNET Detail
Mechanistically, PCAF-mediated Akt1 acetylation enhanced Akt1 phosphorylation at both sites of Thr(3... DisGeNET Detail
We previously demonstrated that TMZ treatment of LGG induces driver mutations in the RB and AKT-mTOR... DisGeNET Detail
Exogenous miR-542-3p suppressed glioblastoma cell invasion through not only targeting AKT1 itself bu... DisGeNET Detail
A crucial AKT regulator, ACK1 (TNK2) has been shown to be a downstream mediator of PDGF signaling; h... DisGeNET Detail
As hyperactivation of the PI3K/AKT/mTOR pathway is frequently observed in gliomas, the combined use ... DisGeNET Detail
Suppressed expression of miR-637 and increased Akt1 protein levels were correlated with unfavorable ... DisGeNET Detail
Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion... DisGeNET Detail
VEGFR2 inhibitor SU-1498, AKT inhibitor LY294002 and FAK inhibitor 14 (FAK inhibitor) blocked the Ro... DisGeNET Detail
Finally, inspired by these newly identified tumor-suppressive functions of PARK2, we tested and prov... DisGeNET Detail
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Our findings not only reveal a key role of TRAF3 in regulating the hypertrophic response but also un... DisGeNET Detail
Our findings not only reveal a key role of TRAF3 in regulating the hypertrophic response but also un... DisGeNET Detail
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Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the ... DisGeNET Detail
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Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. DisGeNET Detail
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miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas. DisGeNET Detail
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In conclusion, these findings indicate that GPNMB has neuroprotective effects against IRI, via phosp... DisGeNET Detail
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The positive loops hyperactivate AKT locus forming a cancer phenotype in leukemia, lymphoma, myeloma... DisGeNET Detail
Using genetically modified mice, we found that loss of Id1 inhibited t(8;21) leukemia initiation and... DisGeNET Detail
Altogether, these results underline the key role of PI3K/AKT pathway in the generation of the CLL pr... DisGeNET Detail
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signa... DisGeNET Detail
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These data support a strong biological link between NF-kB and PI3-kinase/AKT pathways in the modulat... DisGeNET Detail
In acute myeloid leukemia (AML), several signaling pathways such as the phosphatidylinositol-3-kinas... DisGeNET Detail
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The present article provides an overview of our current knowledge about the critical role of AKT and... DisGeNET Detail
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SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice. DisGeNET Detail
Furthermore, miR-101 significantly suppressed both c-Myc and AKT/Ras liver tumor development. DisGeNET Detail
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AKT expression was present in all FL and lymphadenitis cases. DisGeNET Detail
Here, we show that during chronic murine lymphocytic choriomeningitis virus infection, activation of... DisGeNET Detail
Upregulation of hClock enhanced the activity of the anti‑apoptotic gene phosphorpylated (p‑)AKT and ... DisGeNET Detail
Hence, antagomirs to miR-BART20-5p or miR-494-3p, miR-142-3p mimics, or AKT inhibitors may be useful... DisGeNET Detail
Constitutive AKT activation in follicular lymphoma. DisGeNET Detail
IL-32 contributes to gastric cancer progression by increasing the metastatic potential resulting fro... DisGeNET Detail
Disruption of EGFL7-EGFR-AKT-Snail signaling may a promising therapeutic strategy for gastric cancer... DisGeNET Detail
In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a novel mechanism for gas... DisGeNET Detail
Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathway. DisGeNET Detail
In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, alo... DisGeNET Detail
In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AKT activation in gast... DisGeNET Detail
The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a novel therapeutic targ... DisGeNET Detail
ECHS1 may play important roles in gastric cancer cell proliferation and migration through PKB- and G... DisGeNET Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC... DisGeNET Detail
In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. DisGeNET Detail
Our studies revealed that miR-29s expression is downregulated in GC and they could repress the AKT2 ... DisGeNET Detail
Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT and ERK signaling pa... DisGeNET Detail
MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. DisGeNET Detail
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Protein kinase B (AKT1) genotype mediates sensitivity to cannabis-induced impairments in psychomotor... DisGeNET Detail
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Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma. DisGeNET Detail
These results add to the understanding of the molecular characteristics of melanoma brain metastases... DisGeNET Detail
The findings add to evidence supporting a significant role for PTEN loss and the PI3K-AKT pathway in... DisGeNET Detail
Analysis of tumor adjacent normal skin from these mice revealed altered expression of several biomar... DisGeNET Detail
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. DisGeNET Detail
Activated PI3K-AKT pathway may contribute to decrease sensitivity to inhibitors of key pathogenetic ... DisGeNET Detail
Clinical and prognostic significance of survivin, AKT and VEGF in primary mucosal oral melanoma. DisGeNET Detail
Furthermore, we show that ectopically expressed SPINT2 in melanoma cells inhibits the HGF-induced ME... DisGeNET Detail
PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein kinase B pathway to... DisGeNET Detail
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Inhibition of TGM2 function by siRNA or cystamine induced meningioma cell death, which was associate... DisGeNET Detail
The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling... DisGeNET Detail
Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation. DisGeNET Detail
Several proapoptotic genes (AKT1 and AKT2) were down-regulated and antiapoptotic genes (APAF1 and BC... DisGeNET Detail
Several proapoptotic genes (AKT1 and AKT2) were down-regulated and antiapoptotic genes (APAF1 and BC... DisGeNET Detail
Furthermore, our results demonstrated that the enforced expression of miR-145 in H929 cells profound... DisGeNET Detail
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We have already shown that AKT is activated in skin lesions in Mycosis Fungoides (MF) and we herein ... DisGeNET Detail
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Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlates with poor prognos... DisGeNET Detail
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For the first time mutation of AKT1 (c.49G > A) gene was detected both in cranial exostosis and in c... DisGeNET Detail
Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteosarcoma cells and upr... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer. DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
Furthermore, overexpression of miR‑338‑3p inhibited phosphorylation of PI3K and AKT, which contribut... DisGeNET Detail
We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is oncogenic in NIH/3T3 cel... DisGeNET Detail
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Based on analyses of mice, loss of sst2 from pancreatic tissues activates PI3K signaling via AKT, le... DisGeNET Detail
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Thus, in neurodegenerative states such as PD, maintaining the thiol status of cysteines 296 and 310 ... DisGeNET Detail
Using patient-derived tumor cell models isolated from pericardial effusion of HER2(+) and MET(+) GC ... DisGeNET Detail
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Phosphorylation of β-catenin at Ser552 via the miR-21-mediated PTEN/AKT axis plays a critical role i... DisGeNET Detail
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Collectively, this study implies a significant fibrogenic induction activity of rapamycin by activat... DisGeNET Detail
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MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected pho... DisGeNET Detail
Here, we identify a novel synthetic lethality of concomitant inhibition of HH and PI3K/AKT/mTOR path... DisGeNET Detail
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We have already shown that AKT is activated in skin lesions in Mycosis Fungoides (MF) and we herein ... DisGeNET Detail
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In two MET-amplified human gastric tumor xenograft models, SNU-5 and Hs 746T, intravenous treatment ... DisGeNET Detail
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The survival of CSF1R(pos) cells requires active AKT (v-akt murine thymoma viral oncogene homolog 1)... DisGeNET Detail
Furthermore, we show that ectopically expressed SPINT2 in melanoma cells inhibits the HGF-induced ME... DisGeNET Detail
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In cell culture models of TSC2-deficient LAM patient-derived and rat uterine leiomyoma-derived cells... DisGeNET Detail
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Many alterations directly or indirectly lead to activation of survival signaling pathways and expres... DisGeNET Detail
TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeos... DisGeNET Detail
It was previously shown that cyclic AMP (cAMP) induces sensitivity to GCs by inhibiting the AKT/mTOR... DisGeNET Detail
However, there have been preclinical data showing PI3K/AKT pathway activation in T-cell lymphoma, wi... DisGeNET Detail
The absence of Esr2 resulted in increased apoptosis, decreased B-cell lymphoma 2 (BCL2), and IGF-1 r... DisGeNET Detail
Lupalbigenin treatment significantly down-regulated survival proteins, including protein kinase B (p... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) sig... DisGeNET Detail
Treatment of DLBCL cells with EtOH suppressed mTORC1 complex formation while increasing AKT phosphor... DisGeNET Detail
However, there have been preclinical data showing PI3K/AKT pathway activation in T-cell lymphoma, wi... DisGeNET Detail
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The clinical significance of activated p-AKT expression in peripheral T-cell lymphoma. DisGeNET Detail
Proteus syndrome is caused by an activating AKT1 mutation (c.49G>A, p.Glu17Lys). DisGeNET Detail
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Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a compre... DisGeNET Detail
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Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma. DisGeNET Detail
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Here, we show that during chronic murine lymphocytic choriomeningitis virus infection, activation of... DisGeNET Detail
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Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor and Caused by AKT and ... DisGeNET Detail
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Therefore, our study addressed a novel role of CIP2A in mediating cancer progression through interac... DisGeNET Detail
Elevated levels of extracellular glutamate were observed in mGluR1-expressing breast cancer cell lin... DisGeNET Detail
This review discusses the role of PRAS40 and possible feedback mechanisms, and alterations in AKT/PR... DisGeNET Detail
We found that the in vitro stimulation of DDLPS cells with hepatocyte growth factor (HGF) elevated t... DisGeNET Detail
FGFR3, AKT1, and PIK3CA mutations are all reported for the first time in GCT. DisGeNET Detail
In addition to the commonly known AP-1 activators Mitogen-Activated Protein Kinases (MAPKs), there a... DisGeNET Detail
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Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
The transposase-mediated transduction of constitutively active AKT and Yes-associated protein in the... DisGeNET Detail
REDD1 and p-AKT expressions were significantly higher in serous adenocarcinoma than other histologic... DisGeNET Detail
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Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumor... DisGeNET Detail
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The present article provides an overview of our current knowledge about the critical role of AKT and... DisGeNET Detail
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cort... DisGeNET Detail
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Two selected anti-AXL mAbs (D9 and E8), which inhibited phosphorylation of AXL and of its downstream... DisGeNET Detail
In conclusion, the present study reveals that the increased expression of OCT4 is correlated with th... DisGeNET Detail
Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
GDC-0980 inhibited AKT-mTOR activation and pancreatic cancer cell (PANC-1 and Capan-1 lines) surviva... DisGeNET Detail
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microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT... DisGeNET Detail
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Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer. DisGeNET Detail
Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) exp... DisGeNET Detail
Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor MEK-162 synergisticall... DisGeNET Detail
Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung ... DisGeNET Detail
Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 over-expression using ... DisGeNET Detail
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PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cort... DisGeNET Detail
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Guanine nucleotide binding protein alpha13 (GNA13) and protein tyrosine phosphatase type IVA (PTP4A)... DisGeNET Detail
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Activated PI3K/AKT/mTOR pathway frequently occurs in metastatic or recurrent cervical carcinomas. DisGeNET Detail
Eighty-nine cases of pure high-grade DCIS and 119 cases of high-grade DCIS associated with IBC were ... DisGeNET Detail
Introduction of RASSF6 into a B-Raf(V600E)-containing metastatic melanoma cell line inhibited its ab... DisGeNET Detail
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The rGEP was shown to trigger phosphorylation of AKT and ERK1/2 in liver cancer cells. DisGeNET Detail
As a trigger of Rac GTPase signaling after G protein-coupled receptors (GPCR) activated by CXCL9, Ph... DisGeNET Detail
PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast c... DisGeNET Detail
Taken together, our results suggest a novel and critical role of TIP30 involved in TGF-β1-induced ac... DisGeNET Detail
It was tested using an AKT shRNA knockdown of ESCC cell lines and the in vivo tumor suppressive effe... DisGeNET Detail
Dasatinib enhances cisplatin sensitivity in human esophageal squamous cell carcinoma (ESCC) cells vi... DisGeNET Detail
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The objective of this study was to investigate the predictive value of common genetic alterations of... DisGeNET Detail
Both decreased MLH1 and increased AKT levels induced lower PMS2, indicating that MMR was mediated by... DisGeNET Detail
Increased activity of PI3K/AKT/PMS2 could play a role in SETD2 mutated ccRCC. DisGeNET Detail
Impaired fatty acid synthesis was associated with reduced solid tumor cell proliferation, the format... DisGeNET Detail
TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeos... DisGeNET Detail
NA DisGeNET Detail
PIK3CA mutations are more common in HPV(+) OPSCC and are associated with activation of mTOR, but not... DisGeNET Detail
Taken together, our study points to a critical role of MYBBP1A in the regulation of senescence under... DisGeNET Detail
Ectopic transfection of miR-375 led to a significant reduction in IGF1R and its downstream signaling... DisGeNET Detail
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Additionally, treatment with butein significantly increased reactive oxygen species (ROS) generation... DisGeNET Detail
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Similarly, high-dose G-CSF (or downstream signaling through AKT/BCL2) rescues the dysgranulopoietic ... DisGeNET Detail
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NA DisGeNET Detail
The rGEP was shown to trigger phosphorylation of AKT and ERK1/2 in liver cancer cells. DisGeNET Detail
As a trigger of Rac GTPase signaling after G protein-coupled receptors (GPCR) activated by CXCL9, Ph... DisGeNET Detail
NA DisGeNET Detail
These findings suggest that NK4 acts as a CSC inhibitor by impeding Met/AKT/β-catenin signaling and ... DisGeNET Detail
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NA DisGeNET Detail
Two selected anti-AXL mAbs (D9 and E8), which inhibited phosphorylation of AXL and of its downstream... DisGeNET Detail
In conclusion, the present study reveals that the increased expression of OCT4 is correlated with th... DisGeNET Detail
Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
GDC-0980 inhibited AKT-mTOR activation and pancreatic cancer cell (PANC-1 and Capan-1 lines) surviva... DisGeNET Detail
NA DisGeNET Detail
Decreases in blood AKT1 and mTOR mRNA expression, as well as in BAD/BCL-2 expression ratio were obse... DisGeNET Detail
NA DisGeNET Detail
miR-29b functions as a tumor suppressor in TSCC, and the miR-29b/Sp1/PTEN/AKT axis might represent a... DisGeNET Detail
NA DisGeNET Detail
Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via th... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumor spheroid maintenan... DisGeNET Detail
Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate c... DisGeNET Detail
Complex impacts of PI3K/AKT inhibitors to androgen receptor gene expression in prostate cancer cells... DisGeNET Detail
Our findings offer new insight in the regulation of the PTEN/AKT pathway and provide a molecular bas... DisGeNET Detail
MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The activation of a central growth/survival pathway (PI3K/AKT) represents a feasible target for the ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cort... DisGeNET Detail
The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutan... DisGeNET Detail
Endometrial cancers have been recently molecularly characterized; amplifications of human epidermal ... DisGeNET Detail
NA DisGeNET Detail
The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through ... DisGeNET Detail
This review will focus on the role of AKT in the uterus and its function in processes related to cel... DisGeNET Detail
Targeting key signaling components of PI3K/AKT pathway by restoring or inhibiting miRNA function hol... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neuro... DisGeNET Detail
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In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathway in esophageal can... DisGeNET Detail
Intrinsic defect in B-lymphoblastoid cell lines from patients with X-linked lymphoproliferative dise... DisGeNET Detail
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NA DisGeNET Detail
We identified frequent PIK3CA mutations in patients with high-risk HNSCC confined predominantly to t... DisGeNET Detail
NA DisGeNET Detail
Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteosarcoma cells and upr... DisGeNET Detail
NA DisGeNET Detail
Together, these observations suggest that STAT5 and AKT are key drivers of oncogenesis in drug-resis... DisGeNET Detail
Akt1 has an important role in lung carcinogenesis, and depletion of Akt1 has been shown to have anti... DisGeNET Detail
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab res... DisGeNET Detail
Overexpression of miR-320a led to the inhibition of cell proliferation, migration, invasion, as well... DisGeNET Detail
Functional analyses revealed their contribution to prostate carcinogenesis by targeting relevant pat... DisGeNET Detail
The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motilit... DisGeNET Detail
In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AKT activation in gast... DisGeNET Detail
In summary, AR overexpression induced by AKT phosphorylation upregulated MMP9 by binding to its prom... DisGeNET Detail
Then, miRNA-regulated protein interaction network was constructed and 5 topological features ('Degre... DisGeNET Detail
The transposase-mediated transduction of constitutively active AKT and Yes-associated protein in the... DisGeNET Detail
Our results demonstrate a central role of miR-22 in the physiologic regulation of MDC1-dependent DDR... DisGeNET Detail
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to... DisGeNET Detail
Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 over-expression using ... DisGeNET Detail
The interconnected Ras/ERK and PI3K/AKT pathways play a central role in colorectal tumorigenesis, an... DisGeNET Detail
We then performed in vivo experiments and found that the Id1 inhibitor significantly prolonged the s... DisGeNET Detail
Here, we show that AKT2 is exclusively required for PTEN-deficient prostate tumor spheroid maintenan... DisGeNET Detail
Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A₂α via AKT in prostate c... DisGeNET Detail
Complex impacts of PI3K/AKT inhibitors to androgen receptor gene expression in prostate cancer cells... DisGeNET Detail
Our findings offer new insight in the regulation of the PTEN/AKT pathway and provide a molecular bas... DisGeNET Detail
MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. DisGeNET Detail
NA DisGeNET Detail
Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. DisGeNET Detail
We established that amplifications in 14q32.33 were associated with reduced OS, PFS, PFI and platinu... DisGeNET Detail
Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pathway in epithelial o... DisGeNET Detail
CXCR7 signaling induced epithelial-mesenchymal transition by AKT and ERK pathways in epithelial ovar... DisGeNET Detail
Rab25 is responsible for phosphoinositide 3-kinase/AKT‑mediated cisplatin resistance in human epithe... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
As expected, rapamycin inhibition of mTOR results in feedback activation of AKT in breast cancer cel... DisGeNET Detail
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab res... DisGeNET Detail
In this study, germline SNPs in the PI3 K-AKT-mTOR pathway were associated with breast cancer DFS an... DisGeNET Detail
The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) si... DisGeNET Detail
A significant reduction in post-relapse breast cancer-specific survival was associated with low-ER r... DisGeNET Detail
Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatid... DisGeNET Detail
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-... DisGeNET Detail
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybri... DisGeNET Detail
RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitro, implying that RA-... DisGeNET Detail
Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is associated with high... DisGeNET Detail
Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast canc... DisGeNET Detail
This study provides a novel treatment strategy that PI3K/AKT/mTOR pathway inhibitors in combination ... DisGeNET Detail
Suppression of AKT expression by miR-153 produced anti-tumor activity in lung cancer. DisGeNET Detail
Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) exp... DisGeNET Detail
Here, we reported that the AKT inhibitor perifosine and the MEK\ERK inhibitor MEK-162 synergisticall... DisGeNET Detail
Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung ... DisGeNET Detail
Here, we examined the effectiveness of simultaneous Akt1 inhibition and Pdcd4 over-expression using ... DisGeNET Detail
NA DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
Thereby, PTEN/PI3K/AKT/NF-κB/paxillin signaling cascade is an attractive therapeutic target for colo... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
IL-32 contributes to gastric cancer progression by increasing the metastatic potential resulting fro... DisGeNET Detail
Disruption of EGFL7-EGFR-AKT-Snail signaling may a promising therapeutic strategy for gastric cancer... DisGeNET Detail
In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a novel mechanism for gas... DisGeNET Detail
Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathway. DisGeNET Detail
In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, alo... DisGeNET Detail
In conclusion, our findings reveal decreased let-7b/g contributes to aberrant AKT activation in gast... DisGeNET Detail
The AKT/AR/MMP9 pathway plays an important role in GC metastasis and may be a novel therapeutic targ... DisGeNET Detail
ECHS1 may play important roles in gastric cancer cell proliferation and migration through PKB- and G... DisGeNET Detail
Knockdown of EGFR reduced cell proliferation and invasion of GC with decreased expression of AKT, PC... DisGeNET Detail
In conclusion, knockdown of the c‑Met gene promoted gastric cancer cell apoptosis and inhibited down... DisGeNET Detail
MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. DisGeNET Detail
Our studies revealed that miR-29s expression is downregulated in GC and they could repress the AKT2 ... DisGeNET Detail
Bone morphogenetic protein 2 mediates epithelial-mesenchymal transition via AKT and ERK signaling pa... DisGeNET Detail
MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2. DisGeNET Detail
Mechanism studies suggest that ERα could control the expression of INPP4B to reduce AKT activity and... DisGeNET Detail
Taken together, these findings highlight for the first time that ANG could play a pivotal role in th... DisGeNET Detail
NA DisGeNET Detail
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib i... DisGeNET Detail
Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlates with poor prognos... DisGeNET Detail
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NA DisGeNET Detail
Western blotting results showed the p-p70S6K, p-Gli1, p-mTOR, and p-AKT protein expression were inhi... DisGeNET Detail
The above observation was further substantiated by the finding that a majority of the MPM archival s... DisGeNET Detail
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NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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The prototype infantile tauopathy is (1) hemimegalencephaly (HME); normal tau is degraded by a mutan... DisGeNET Detail
NA DisGeNET Detail
In this study we performed multiplex targeted sequencing of 10 genes in the PI3K/AKT pathway on brai... DisGeNET Detail
MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the P... DisGeNET Detail
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer. DisGeNET Detail
The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer. DisGeNET Detail
Furthermore, overexpression of miR‑338‑3p inhibited phosphorylation of PI3K and AKT, which contribut... DisGeNET Detail
We conclude that the carboxy-terminal portion of the MUC16/CA125 protein is oncogenic in NIH/3T3 cel... DisGeNET Detail
Two HNSCC and a control keratinocyte cell lines were treated with EGF and wortmannin to respectively... DisGeNET Detail
We identified frequent PIK3CA mutations in patients with high-risk HNSCC confined predominantly to t... DisGeNET Detail
PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients with head and neck s... DisGeNET Detail
Likewise, we examined the activation of the PI3K/AKT/mTOR pathway in HNSCC tumors by RPPA. DisGeNET Detail
Enhanced expression of sprouty2 protein suppressed the growth of HNSCC cells and signaling of the ph... DisGeNET Detail
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For the first time mutation of AKT1 (c.49G > A) gene was detected both in cranial exostosis and in c... DisGeNET Detail
IR-induced cell death was also associated with downregulation of v-src sarcoma (Schmidt-Ruppin A-2) ... DisGeNET Detail
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Immunohistochemical staining for PDGFα; PDGFβ; PDGFR-α; PDGFR-β; IGF1R; EGFR; VEGF; IGF2; c-Met; c-k... DisGeNET Detail
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Proteus syndrome: Report of a case with AKT1 mutation in a dental cyst. DisGeNET Detail
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In conclusion, SELP and AKT1 polymorphisms may play a role in the risk of cachexia and death in PDAC... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeos... DisGeNET Detail
NA DisGeNET Detail
Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experienc... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Regulation of AKT by BRCA1 in both our cell model and BRCA1-mutated breast tumors was suggested to p... DisGeNET Detail
Future studies are needed to replicate our results and to evaluate the relationship between these po... DisGeNET Detail
In addition, inhibitors to the AKT/IGF-1R signaling pathways may provide alternative approaches to b... DisGeNET Detail
NA DisGeNET Detail
Altogether, the present data indicate that SKP2 cooperates with N-Ras and AKT proto-oncogenes to pro... DisGeNET Detail
Noticeably, miR-375 showed limited antineoplastic activity against c-Myc driven tumorigenesis, where... DisGeNET Detail
NA DisGeNET Detail
These findings establish ShcA as a biological bridge that links AKT activation downstream of RTKs to... DisGeNET Detail
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Our results show that the clinical candidate AKT inhibitor MK-2206 promotes ARF nucleolar localizati... DisGeNET Detail
The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways i... DisGeNET Detail
Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated ... DisGeNET Detail
Expression of Ang-2/Tie-2 and PI3K/AKT in colorectal cancer. DisGeNET Detail
Portrait of the PI3K/AKT pathway in colorectal cancer. DisGeNET Detail
Activation of MAPK/ERK1/2 and PI3k/AKT pathways is required for HPIP modulation of CRC cell prolifer... DisGeNET Detail
We analyzed the mutation spectra of the PI3K/PTEN/AKT and RAS/RAF/MAPK pathways in colorectal cancer... DisGeNET Detail
NA DisGeNET Detail
Preclinical investigations have suggested that the PI3K/AKT/mTOR pathway is frequently activated in ... DisGeNET Detail
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Inhibition of TGM2 function by siRNA or cystamine induced meningioma cell death, which was associate... DisGeNET Detail
The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling... DisGeNET Detail
NA DisGeNET Detail
Similarly, high-dose G-CSF (or downstream signaling through AKT/BCL2) rescues the dysgranulopoietic ... DisGeNET Detail
NA DisGeNET Detail
In cell culture models of TSC2-deficient LAM patient-derived and rat uterine leiomyoma-derived cells... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through ... DisGeNET Detail
This review will focus on the role of AKT in the uterus and its function in processes related to cel... DisGeNET Detail
Targeting key signaling components of PI3K/AKT pathway by restoring or inhibiting miRNA function hol... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We also explored the molecular mechanism of FHL1C overexpression-induced apoptosis, which suppressed... DisGeNET Detail
Although high mTORC2-AKT activation is commonly associated with drug-resistance, we demonstrate that... DisGeNET Detail
Using a focused chemical genomic approach, we demonstrate that xenografted cell lines harboring muta... DisGeNET Detail
PTEN and NOTCH1 mutations were almost mutually exclusive, while IL7R and WT1 mutations were rare in ... DisGeNET Detail
We previously demonstrated that TMZ treatment of LGG induces driver mutations in the RB and AKT-mTOR... DisGeNET Detail
NA DisGeNET Detail
The bFGF-stimulated activation of protein kinase B (AKT) and extracellular signal-regulated kinase (... DisGeNET Detail
In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de... DisGeNET Detail
The newly identified miR-149/AKT/mTOR axis might be a promising therapeutic target in the prevention... DisGeNET Detail
The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target ... DisGeNET Detail
The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathwa... DisGeNET Detail
Depletion of DUOX2 abrogated PKCα-induced activation of AKT/MAPK pathways as well as cell proliferat... DisGeNET Detail
LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosp... DisGeNET Detail
Because of the frequent PIK3CA and AKT1 mutations in patients with oropharyngeal carcinoma, we evalu... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cort... DisGeNET Detail
Furthermore, restoration of INPP4B expression significantly suppressed PI3K/AKT downstream signals i... DisGeNET Detail
Reduced PTEN and PPP2R2B expression correlated with activated AKT/mTOR and PDK1/MYC pathways and con... DisGeNET Detail
NA DisGeNET Detail
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KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast canc... DisGeNET Detail
Different targeted therapies may be necessary for TNBC that involves activation of PI3K/AKT or MAPK ... DisGeNET Detail
Our findings suggest that SPHK1 inhibition, which effectively counteracts oncogenic signaling throug... DisGeNET Detail
NA DisGeNET Detail
Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X syndrome (FXS) and intel... DisGeNET Detail
NA DisGeNET Detail
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-... DisGeNET Detail
NA DisGeNET Detail
The small interfering RNA (siRNA) was used to suppress CrkL in serous papillary cystic adenocarcinom... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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Our findings identify JNK-dependent modulation of mRNA stability as an important PKB-independent mec... DisGeNET Detail
These results suggest that using SPRY2 to block the AKT and ERK pathways suppresses the inflammatory... DisGeNET Detail
MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
Overall, the results reinforce a role for AKT1 and mTOR in the pathophysiology of BD and support the... DisGeNET Detail
Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder. DisGeNET Detail
Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: its potential use in the treatment o... DisGeNET Detail
Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2. DisGeNET Detail
Mechanism studies suggest that ERα could control the expression of INPP4B to reduce AKT activity and... DisGeNET Detail
Taken together, these findings highlight for the first time that ANG could play a pivotal role in th... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
As expected, rapamycin inhibition of mTOR results in feedback activation of AKT in breast cancer cel... DisGeNET Detail
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab res... DisGeNET Detail
In this study, germline SNPs in the PI3 K-AKT-mTOR pathway were associated with breast cancer DFS an... DisGeNET Detail
The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) si... DisGeNET Detail
A significant reduction in post-relapse breast cancer-specific survival was associated with low-ER r... DisGeNET Detail
Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatid... DisGeNET Detail
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-... DisGeNET Detail
Epidermal growth factor receptor and AKT1 gene copy numbers by multi-gene fluorescence in situ hybri... DisGeNET Detail
RA-V inhibits breast cancer cell migration, adhesion and ECM degradation in vitro, implying that RA-... DisGeNET Detail
Resistance to trastuzumab in patients with HER2-overexpressing breast cancer is associated with high... DisGeNET Detail
Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast canc... DisGeNET Detail
This study provides a novel treatment strategy that PI3K/AKT/mTOR pathway inhibitors in combination ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients. DisGeNET Detail
In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase... DisGeNET Detail
Thereby, PTEN/PI3K/AKT/NF-κB/paxillin signaling cascade is an attractive therapeutic target for colo... DisGeNET Detail
Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT... DisGeNET Detail
The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through ... DisGeNET Detail
This review will focus on the role of AKT in the uterus and its function in processes related to cel... DisGeNET Detail
Targeting key signaling components of PI3K/AKT pathway by restoring or inhibiting miRNA function hol... DisGeNET Detail
NA DisGeNET Detail
Using a database of 735 colon and rectal cancers in the Nurse's Health Study and the Health Professi... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Eighty-nine cases of pure high-grade DCIS and 119 cases of high-grade DCIS associated with IBC were ... DisGeNET Detail
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Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces ... DisGeNET Detail
AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptos... DisGeNET Detail
Therefore, the AKT inhibitor perifosine might potentially overcome the resistance to cisplatin-based... DisGeNET Detail
Next, we discovered that LMO1 promoted cancer cell proliferation in our in vitro/vivo cell prolifera... DisGeNET Detail
Restored the expression of AKT1 partially abolished the suppressive effects miR-99a on proliferation... DisGeNET Detail
These results suggested that miR-548l may play a causal role through AKT1 in NSCLC invasion and meta... DisGeNET Detail
Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell li... DisGeNET Detail
Inhibition of the AKT pathway attenuated the biological functions of NSCLC cells induced by overexpr... DisGeNET Detail
However, the role of ERK1/2 and AKT-mediated XRCC1 expression in gefitinib alone or combination with... DisGeNET Detail
In addition to selective inhibitors of ERK1/2, AKT, IKBα and NF-κβ, as therapeutic options, our data... DisGeNET Detail
ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates wi... DisGeNET Detail
NA DisGeNET Detail
We genotyped 70 genes involved in the pathogenesis of renal-cell carcinoma (including the VHL/HIF/VE... DisGeNET Detail
Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor and Caused by AKT and ... DisGeNET Detail
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an import... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
Genome
hg19
Position
chr14:105,235,686-105,262,096
Variant Type
snv
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