Annotation Detail
Information
- Associated Genes
- TOP2A
- Associated Variants
- TOP2A UNKNOWN
- Source Database
- MMMP
- Description
- The acquisition of the mutant allele of topoisomerase IIalpha confers a selective advantage to cells in the presence of VP-16. As the drug concentration increased during the selection process, surviving sublines show preferential expression of the mutant topoisomerase IIalpha mRNA over that of the wild-type
- MMMP State
- mut Ala429del
- MMMP Molecule
- Topoisomerase II alpha
- MMMP Molecule Alias
- TOP2A
- MMMP Relationship
- resistance to
- MMMP Drug
- Etoposide
- MMMP Drug Alias
- VP-16
- MMMP Model
- 3
- MMMP Reference
- Campain JA, Somat Cell Mol Genet 1995, 21:451-71
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Etoposide | Resitance or Non-Reponse | true |