nicotine dependence

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Information
Disease name
nicotine dependence
Disease ID
DOID:0050742
Description
"A substance dependence that is characterized by a physical dependence on nicotine." [url:https\://en.wikipedia.org/wiki/Nicotine_dependence]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05327439 Active, not recruiting N/A Using ANDS to Reduce Harm for Low SES Cigarette Smokers March 23, 2022 February 9, 2023
NCT05367492 Active, not recruiting Phase 4 Varenicline for Nicotine Vaping Cessation in Adolescents June 22, 2022 June 2024
NCT00129246 Completed Phase 1/Phase 2 Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain December 2004 December 2005
NCT00133757 Completed Phase 1 Use of Pharmacotherapy to Reduce Cue-responsiveness in Smokers June 2005 May 2006
NCT00134927 Completed A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches September 2005 November 2006
NCT00186446 Completed Phase 4 Treatment of Nicotine Dependence and Acute Depression June 2004 September 2007
NCT00218465 Completed Phase 2 Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking August 2006 June 2009
NCT00264342 Completed Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction July 2005 July 2010
NCT00267813 Completed N/A The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers July 2004 October 2007
NCT00273156 Completed Phase 3 A Brief Dental Office Intervention With Tobacco Quitline February 2005 December 2006
NCT00289653 Completed N/A Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation September 2005 July 2009
NCT00297453 Completed Phase 3 Smoking Treatment in HIV Clinical Care Settings January 2006 January 2011
NCT00301626 Completed N/A ROSCAP: Reduction of Smoking in Cardiac Patients Study October 2000 January 2005
NCT00330187 Completed Phase 2 Combined Pharmaco/Behavior Therapy in Adolescent Smokers March 2004 July 2009
NCT00332644 Completed Phase 4 Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms September 2004 August 2010
NCT00344695 Completed Phase 3 Bupropion Treatment for Youth Smoking Cessation April 2003
NCT03190161 Completed N/A Music to Reduce Use of Smoking in Patients With Schizophrenia March 9, 2017 September 17, 2018
NCT00108173 Completed Phase 1 Brain Reaction to Treatment of Nicotine Dependence October 2002 June 2011
NCT01954966 Completed Phase 4 Progesterone and Brain Imaging Study November 2010 December 2021
NCT01980550 Completed Phase 4 Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy March 2004 December 2004
NCT01982110 Completed N/A A Mindfulness Based Application for Smoking Cessation September 2013 October 2018
NCT01982617 Completed N/A Motivational Interviewing Compared to Psychoeducation for Smoking Precontemplators With SMI January 2003 January 2013
NCT01989507 Completed Phase 2 Very Low-Nicotine Cigarettes in Smokers With SUD April 2014 May 31, 2021
NCT02048852 Completed N/A Manipulating Tobacco Constituents in Female Menthol Smokers July 2014 July 2020
NCT02083081 Completed N/A Community Intervention to Reduce Tobacco Use in Pregnant Women May 2014 December 2020
NCT02102100 Completed N/A The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users March 26, 2014 July 11, 2016
NCT02108626 Completed Phase 4 Electronic Cigarettes in Daily Dependent Smokers March 2014 April 2015
NCT02117947 Completed N/A Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers July 2004 June 2011
NCT02129387 Completed EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers April 2014 November 30, 2021
NCT02139930 Completed N/A Project 2: Strategies for Reducing Nicotine Content in Cigarettes September 2014 March 14, 2017
NCT02146911 Completed N/A The MATCH (Medication Aids for Tobacco Cessation and Health) Study May 1, 2014 December 31, 2016
NCT02151591 Completed Phase 1 New Approaches to Smoking Cessation in Heavy Drinkers March 1, 2017 August 1, 2018
NCT02164383 Completed N/A A Quit Smoking Study Using Smartphones October 2014 May 2016
NCT02188459 Completed Phase 2 Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women October 30, 2014 January 22, 2020
NCT02348385 Completed Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers December 2012 December 2017
NCT02357173 Completed N/A A Trial of E-cigarettes in Current Cigarette Smokers November 2014 July 2017
NCT02358330 Completed Project 1: Evaluating EHR-Based Health System Modifications for the Chronic Care of Smoking February 2015 August 1, 2018
NCT02378714 Completed Phase 4 Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers July 24, 2015 March 13, 2020
NCT02401672 Completed N/A Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction May 14, 2014 December 30, 2018
NCT02431611 Completed Phase 2 Biomarker Feedback to Motivate Cessation in Pregnancy March 2015 December 2017
NCT02433015 Completed N/A Neurophysiological and Immunological Effects of the Transition From Combustible to Electronic Cigarettes January 2015 September 24, 2016
NCT02448654 Completed N/A Treatment for Nicotine Addiction in Women October 23, 2015 June 30, 2019
NCT02470754 Completed N/A Clinical Pharmacology of Electronic Cigarettes July 23, 2015 February 2, 2018
NCT02498145 Completed N/A Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults October 2014 November 2016
NCT02500589 Completed N/A Adjunctive Mood Management for Telephone-based Smoking Cessation May 31, 2016 April 19, 2019
NCT02501265 Completed Phase 2 Adaptive Pharmacotherapy for Smoking Cessation June 6, 2017 May 12, 2021
NCT02514720 Completed N/A Nicotine Metabolizers and [11C]-(+)-PHNO June 2015 January 2017
NCT02520349 Completed Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal May 2016 August 31, 2018
NCT02527980 Completed E-Cigarettes: Dynamic Patterns of Use and Health Effects October 1, 2015 July 31, 2019
NCT02534454 Completed N/A TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence August 15, 2015 March 31, 2018
NCT02575183 Completed Phase 4 Varenicline (Chantix) Treatment for Waterpipe Smoking Cessation August 31, 2016 March 1, 2021
NCT02587312 Completed N/A Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers October 13, 2016 August 31, 2019
NCT02590393 Completed Phase 1/Phase 2 The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence May 21, 2021 January 13, 2022
NCT02592772 Completed N/A Manipulating Tobacco Constituents in Male Menthol Smokers February 4, 2016 June 2019
NCT02595749 Completed Phase 4 Effects of Intranasal Oxytocin on Cigarette Smoking July 2016 July 2019
NCT02602288 Completed N/A Babies Living Safe and Smokefree February 2016 October 23, 2019
NCT02698215 Completed Phase 2 Combining Varenicline and Naltrexone for Smoking Cessation May 2016 December 2019
NCT02713594 Completed N/A Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation April 2013 March 2017
NCT02724241 Completed N/A E-Cigarettes and SNA April 2015 December 2021
NCT02737358 Completed Phase 2 N-acetylcysteine for Tobacco Use Disorder August 30, 2016 October 10, 2019
NCT02740595 Completed N/A E-cigarettes and Blood Vessel Function August 2015 December 1, 2022
NCT02839382 Completed N/A The Northwest Coalition for Primary Care Practice Support May 1, 2015 May 1, 2018
NCT02840435 Completed N/A Study on Sit to Quit Phone Intervention September 2016 June 2018
NCT02849652 Completed N/A Testing an Organizational Change Model to Address Smoking in Mental Healthcare July 2016 December 2022
NCT02905734 Completed Phase 4 Nicotine Replacement Therapy in Nicotine-dependent Arrestees January 3, 2017 May 30, 2021
NCT02906644 Completed Phase 2 Combination Nicotine Patch / Lorcaserin for Smoking Cessation November 8, 2016 October 18, 2018
NCT02941718 Completed Phase 3 Examination of Sleep, Smoking Cessation, and Cardiovascular Health November 1, 2016 January 17, 2019
NCT02989038 Completed N/A Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers January 2017 December 17, 2019
NCT03000387 Completed Phase 4 Personalized Dosing of Nicotine Replacement (NRT to Effect) January 23, 2018 December 11, 2023
NCT03072628 Completed N/A E-cigarettes, Nicotine Inhaler, and Blood Vessel Function January 11, 2017 December 1, 2022
NCT03077737 Completed N/A Reducing Tobacco Use Disparities Among Low-Income Adults April 21, 2017 August 31, 2018
NCT03080090 Completed N/A YMCA Exercise Intervention for Smoking Cessation Study April 12, 2017 July 6, 2020
NCT03083353 Completed Early Phase 1 Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation January 22, 2020 June 14, 2023
NCT03113136 Completed N/A Examination of Low Wattage and High Wattage E-Cigarettes June 29, 2017 January 31, 2022
NCT03168191 Completed Phase 1 Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2 May 2, 2017 February 25, 2019
NCT03177265 Completed N/A Text Messaging to Engage and Retain Veterans in Smoking Cessation Counseling November 8, 2018 November 1, 2021
NCT00105482 Completed Phase 2 Targeted Interventions for Weight-Concerned Smokers January 2005 October 2009
NCT03194958 Completed N/A Helping Poor Smokers Quit June 5, 2017 July 1, 2022
NCT03196102 Completed N/A Evaluation of a Brief Tobacco Intervention in the US Military April 5, 2017 January 31, 2018
NCT03243630 Completed Early Phase 1 Effects of Flavors on Nicotine Reinforcement in Smokers April 23, 2018 January 31, 2019
NCT03262233 Completed Phase 4 Stress Neuroadaptation in Tobacco Dependence April 1, 2015 February 20, 2018
NCT03272685 Completed Phase 3 Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace June 1, 2018 January 10, 2023
NCT03325777 Completed N/A Approach Bias Retraining to Augment Smoking Cessation November 29, 2017 October 8, 2021
NCT03419741 Completed N/A Brain Stimulation For Cancer Smokers October 21, 2017 October 20, 2020
NCT03471767 Completed Phase 2 AXS-05 Phase II Trial on Smoking Behavior March 25, 2018 March 31, 2019
NCT03496116 Completed N/A The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects May 21, 2018 December 17, 2018
NCT03579953 Completed Early Phase 1 Nicotine TMS EFT Smoking Pilot Study May 22, 2018 June 10, 2019
NCT03580525 Completed Early Phase 1 Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol February 14, 2019 November 19, 2020
NCT03593239 Completed N/A Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers June 29, 2018 July 26, 2018
NCT03700112 Completed N/A Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods. December 4, 2018 April 9, 2019
NCT03719391 Completed N/A United States Pre-Market Tobacco Application Pharmacokinetics October 19, 2018 November 28, 2018
NCT03720899 Completed Phase 2/Phase 3 Comparing NicoBloc to Nicotine Lozenges March 21, 2019 March 3, 2021
NCT03839745 Completed N/A Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power March 26, 2019 December 31, 2021
NCT03847155 Completed N/A Prevention of Nicotine Abstinence in Critically Ill Patients After Major Surgery September 23, 2015 February 8, 2021
NCT04011280 Completed Phase 4 Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness August 12, 2019 March 4, 2022
NCT04043728 Completed N/A Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study September 9, 2019 March 31, 2020
NCT04084210 Completed Phase 2 Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use September 9, 2020 May 23, 2022
NCT04159571 Completed N/A QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt August 20, 2020 November 23, 2022
NCT04161144 Completed Phase 2 Enhancing Self Regulation Among Smokers October 1, 2018 December 20, 2019
NCT04170907 Completed N/A Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine April 19, 2022 August 30, 2022
NCT04262817 Completed Phase 1 The Interaction of Flavor With Nicotine Form in Adult Smokers November 1, 2020 February 2, 2022
NCT04461288 Completed N/A Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment May 1, 2020 May 30, 2022
NCT04506528 Completed COVID EHR COHORT at the University of Wisconsin June 11, 2020 January 31, 2022
NCT04521647 Completed Phase 1 Effects of Menthol in E-cigarettes on Smoking Behaviors May 10, 2022 July 25, 2023
NCT04535362 Completed Early Phase 1 Nicotine's Potential Abuse With Menthol June 28, 2021 June 29, 2023
NCT04646174 Completed N/A Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study December 14, 2020 December 31, 2022
NCT04696380 Completed Phase 2 Do Flavors Increase the Addiction Potential of Nicotine? March 1, 2021 August 31, 2021
NCT04709471 Completed Phase 2 E-cigarette Nicotine Study January 20, 2021 June 1, 2022
NCT04737031 Completed N/A Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke May 18, 2021 July 31, 2022
NCT04832360 Completed N/A Testing Financial Incentive Interventions in Dyadic-Smoker Couples January 15, 2021 August 1, 2022
NCT04857515 Completed Clinical Learning Study for a Mobile Smoking Cessation Program March 12, 2021 June 28, 2021
NCT05041959 Completed N/A Nicotine Withdrawal and Reward Processing June 2, 2022 April 15, 2024
NCT05159934 Completed Phase 1 Nicotine Differences in Smokers February 16, 2022 August 1, 2023
NCT05271175 Completed N/A Accelerated iTBS in Smoking Cessation April 19, 2019 September 7, 2020
NCT05473585 Completed N/A Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2 October 12, 2022 May 9, 2023
NCT05897242 Completed N/A A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults January 4, 2024 April 26, 2024
NCT06091826 Completed Phase 2 Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO) February 21, 2023 September 30, 2023
NCT06163872 Completed Doctors' Perspective on Tobacco Addiction May 1, 2023 September 30, 2023
NCT00400751 Completed Phase 1 Family Consultation for Health-Compromised Smokers September 1999 May 2003
NCT00405912 Completed Phase 2 St. John's Wort for Tobacco Cessation September 2005 March 2008
NCT00407277 Completed N/A Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia February 2007
NCT00408265 Completed Phase 3 Smoking Cessation in Substance Abuse Treatment Patients: A Feasibility Study January 2004 March 2007
NCT00439413 Completed Phase 2 Selegiline for Smoking Cessation - 1 June 2007 January 2009
NCT00459953 Completed Phase 2/Phase 3 Extended Cessation Treatment for Teen Smokers September 2006 July 2011
NCT00469079 Completed Phase 2 Health Effects of SLT, Cigarette Smoking, and New Tobacco Products January 2007 February 2009
NCT00484692 Completed Phase 4 Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation July 2005 January 2007
NCT00497068 Completed Phase 2/Phase 3 Tobacco Use in Opioid Agonist Treated Pregnant Women January 2005 June 2010
NCT00502216 Completed Phase 1/Phase 2 Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers July 2007 June 2009
NCT00563563 Completed Phase 2 A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent October 2007 September 2008
NCT00567320 Completed N/A Efficacy of Varenicline in Methadone-Stabilized Cocaine Users March 2007 August 2009
NCT00578669 Completed Phase 3 Sequential Use of Fluoxetine for Smokers With Elevated Depressive Symptoms April 2008 November 2013
NCT00589277 Completed Phase 1/Phase 2 Message Framing for Telephone Quitline Callers August 2007 May 2009
NCT00595868 Completed Phase 2 Efficacy of Varenicline in Ambivalent Smokers March 2008 January 2010
NCT00596440 Completed Assessment of a Teachable Moment for Smoking Cessation August 2007 February 2012
NCT00602927 Completed N/A Effects of Varenicline on Brain Activity During Nicotine Abstinence November 2007 August 2008
NCT00644137 Completed Early Phase 1 GABA (Gamma Amino Butyric Acid) Medication for Tobacco August 2007 February 2010
NCT00664755 Completed Phase 2 Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity July 2007 December 2013
NCT00682474 Completed Phase 2/Phase 3 School Nurse-Delivered Smoking Cessation Intervention September 2006 February 2010
NCT00709696 Completed N/A Human Laboratory Study Of Varenicline in Smokers April 2008 December 2009
NCT00713063 Completed Phase 2 Behavioral Exercise Intervention for Smoking Cessation April 2006 March 2012
NCT00727103 Completed Phase 4 Varenicline Treatment in Alcohol and Nicotine Dependent Patients With Schizophrenia July 2008 May 2011
NCT00731055 Completed Phase 2 Effects of Varenicline on Cigarette Self Administration February 2008 May 2009
NCT00736255 Completed N/A Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study December 2007 July 2011
NCT00749658 Completed Phase 2/Phase 3 Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence November 2008 September 2010
NCT00751257 Completed Phase 2 N-Acetylcysteine and Smoking Reduction December 2006 October 2007
NCT00756275 Completed N/A Varenicline and Motivational Advice for Smokers With Substance Use Disorders January 2009 September 2014
NCT00770237 Completed N/A Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia October 2008 December 2010
NCT00802412 Completed Phase 2 Topiramate to Aid Smoking Cessation in Alcohol Dependent Men January 2009 June 2015
NCT00813917 Completed N/A Varenicline for the Treatment of Smokeless Tobacco February 2009 January 2011
NCT00816231 Completed N/A Drug /Cue Interactions In Alcohol-Tobacco Comorbidity May 8, 2006 June 20, 2019
NCT00830739 Completed A Multi-Modal Investigation of the Smoking Cessation Medication Varenicline: Dopaminergic Modulation of Reward Processing and Cognitive Control November 25, 2008 February 26, 2013
NCT00831155 Completed Phase 1 Extinction Based Treatment for Nicotine Dependence January 2009 December 2014
NCT00844701 Completed Cue Induced Imaging in Nicotine Dependent Smokers February 2008 December 2009
NCT00860028 Completed Phase 2 Varenicline for Smoking Cessation in Heavy Drinking Smokers October 2008 May 2010
NCT00865254 Completed N/A Prize Reinforcement for Smoking Cessation August 2007 July 2011
NCT00901459 Completed Phase 2 A Controlled Laboratory Study of the Effects on Cue-Induced Craving in Dependent Smokers May 2009 August 2010
NCT00921388 Completed N/A Exercise or Relaxation for Smoking Cessation March 2009 August 29, 2017
NCT00934024 Completed N/A Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers April 2009 January 2012
NCT00936299 Completed Phase 4 Bupropion for ADHD in Adolescents With Substance Use Disorder January 2009 May 2013
NCT00937235 Completed Phase 2 Treatment of Smoking Among Individuals With PTSD January 2009 December 2015
NCT00948155 Completed Phase 4 Measuring Smoking Behaviors While Using Varenicline January 2009 November 2010
NCT00948649 Completed Phase 4 Effects of Chantix on Relapse Prevention for Smoking Cessation September 2006 September 2007
NCT00956943 Completed Phase 2 Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine August 2009 August 2011
NCT00960778 Completed Phase 2 Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes March 2009 June 2012
NCT00969137 Completed Phase 1 Sensitivity to Intravenous Nicotine: Genetic Moderators June 2, 2009 June 1, 2016
NCT00996034 Completed Phase 2 Nicotine Vaccination and Nicotinic Receptor Occupancy September 2009 February 2011
NCT01031121 Completed Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers June 8, 2009 October 22, 2010
NCT01031433 Completed Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality July 28, 2009 July 18, 2012
NCT01031693 Completed Phase 1 Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction July 13, 2009 August 28, 2013
NCT01034020 Completed Phase 1 Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers February 14, 2006 November 3, 2009
NCT01034085 Completed Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia June 2, 2009 June 11, 2013
NCT01036711 Completed Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI September 17, 2002 November 26, 2012
NCT01037153 Completed Effects of Nicotine on Brain Activity as Measured by fMRI August 6, 2002 July 25, 2011
NCT01046513 Completed PET Imaging of Nicotinic Acetylcholine Receptors August 31, 2007 September 28, 2011
NCT01046526 Completed fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia February 8, 2005 May 3, 2012
NCT01047527 Completed Phase 4 An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence June 2009 April 2014
NCT01047930 Completed N/A The Effect of Exercise on Acute Nicotine Withdrawal January 2010 July 2013
NCT01048944 Completed Phase 4 Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers June 2005 January 2013
NCT01048957 Completed N/A The Neural Basis of Cue-Elicited Cigarette Craving and Its Control January 9, 2007 April 8, 2013
NCT01061528 Completed N/A Coping Skills Treatment for Smoking Cessation September 2009 October 2013
NCT01067599 Completed N/A Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 March 2012 October 2016
NCT01077024 Completed Phase 3 Smoking-Cessation and Stimulant Treatment (S-CAST) February 2010 August 2012
NCT01093599 Completed N/A Trial on the Effectiveness of Mindfulness Training for Smokers March 2010 December 2013
NCT01093937 Completed N/A Study of Varenicline (Champix) for Smoking Cessation/Reduction in Patients With Bipolar Disorder November 2009 June 2011
NCT01116986 Completed Phase 4 Identifying Optimal Smoking Cessation Intervention Components (Cessation) June 2010 May 2014
NCT01120080 Completed Phase 1/Phase 2 Alcohol Counseling for Telephone Quitline Callers January 2011 May 2012
NCT01120704 Completed Phase 4 Evaluation of Treatments to Improve Smoking Cessation Medication Adherence June 2010 May 2014
NCT01122238 Completed Phase 4 Identifying Treatments to Motivate Smokers to Quit June 2010 May 2014
NCT01136642 Completed Phase 1 Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray January 21, 2010 November 13, 2012
NCT01144689 Completed N/A Mindfulness Training for Smoking Cessation February 2009 February 2013
NCT01145001 Completed N/A Enhancing a High School Based Smoking Cessation Program November 2009 January 2015
NCT01148355 Completed Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers June 10, 2008 January 14, 2011
NCT01162239 Completed Phase 3 Maintaining Nonsmoking May 2010 June 2016
NCT01166464 Completed N/A Examining a Text Message Intervention for Smoking Cessation July 2009 October 2012
NCT01186055 Completed Brain Activity and Smoking Cessation April 2010 February 2013
NCT01188018 Completed Phase 3 Testing Counseling Styles to Motivate Smokers to Quit October 2010 June 2012
NCT01188967 Completed Phase 2 Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention August 2010 May 2013
NCT01195597 Completed N/A Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD) February 2010 July 2010
NCT01202955 Completed Phase 2 Pilot Study of Tolcapone in Smokers July 2008 June 2009
NCT01204723 Completed Phase 1 Medications Development for the Treatment of Cannabis Related Disorders August 2009 April 2012
NCT01240616 Completed Nicotinic Modulation of the Default Network of Resting Brain Function October 24, 2010 December 24, 2014
NCT01277887 Completed N/A Smoking Cessation for Smokers With Sleep Problems December 2010 March 2012
NCT01280968 Completed Phase 2 Improving the Efficacy of Anti-Nicotine Immunotherapy December 2010 April 2013
NCT01292642 Completed Phase 2 Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence August 2009 June 2011
NCT01299909 Completed N/A Study Two on the Effectiveness of Mindfulness Training for Smokers March 2011 December 2013
NCT01303861 Completed Phase 3 Concurrent Bupropion / Varenicline for Smoking Cessation March 2011 July 2013
NCT01304810 Completed A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation January 2011 August 2011
NCT01342523 Completed Phase 4 Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources October 2011 October 2013
NCT01368653 Completed N/A Evaluation of Learning-Theory-Based Smoking Cessation Strategies June 2012 August 2013
NCT01393301 Completed N/A Integrated Treatment for Smoking Cessation & Anxiety in People With HIV October 2011 May 2015
NCT01393392 Completed Phase 1 Developing a Smoking Cessation Intervention for Methadone Maintained Smokers October 2011 May 2014
NCT01406223 Completed Phase 3 Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation July 2011 June 2014
NCT01412866 Completed N/A Electronic Decision Support Systems for Smokers With Severe Mental Illness May 2011 May 2012
NCT01422239 Completed Phase 1 A Smoking Cessation Treatment for Adult Women January 2011 December 2012
NCT01505725 Completed Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms March 16, 2010 November 29, 2013
NCT01509547 Completed Phase 3 Varenicline for Adolescent Smoking Cessation August 2012 January 26, 2018
NCT01511614 Completed N/A Nicotine Withdrawal Symptoms and Smoking Relapse May 20, 2013 March 30, 2020
NCT01524627 Completed Phase 2 Effects of Varenicline on Smoking Reminders December 2011 November 2015
NCT01553084 Completed Phase 4 A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers May 2012 August 2017
NCT01554436 Completed Phase 4 Neuropsychological Prognosis Factors of Smoking Cessation December 2008 November 2011
NCT01569490 Completed N/A Striving to Quit: First Breath September 2012 December 2016
NCT01576874 Completed N/A The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking June 2012 June 2017
NCT01588561 Completed N/A Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels October 2005 September 2015
NCT01632189 Completed N/A The Effect of Varenicline on D2/D3 Receptor Binding in Smokers September 2012 August 2015
NCT01639079 Completed N/A Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months June 2012 April 2016
NCT01656733 Completed Phase 4 Nicotine Replacement for Smoking Cessation During Pregnancy August 2012 October 25, 2017
NCT01664741 Completed Phase 4 Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging April 2012 December 2018
NCT01679236 Completed Early Phase 1 Pilot Study on Mindfulness for Tobacco and Alcohol in University Students September 2006 September 2009
NCT01685996 Completed Phase 1/Phase 2 Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation September 2012 May 2014
NCT01690130 Completed N/A Transcranial Magnetic Stimulation Effects on Nicotine Craving June 2009 February 2014
NCT01699607 Completed N/A Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm June 2012 July 2013
NCT01702948 Completed Studying Nicotine Addiction With Transcranial Magnetic Stimulation September 10, 2012 October 3, 2017
NCT01710137 Completed Phase 3 Varenicline for Nicotine Dependence Among Those With HIV/AIDS October 2012 September 2018
NCT01735279 Completed Phase 3 Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence January 2013 March 2014
NCT01745393 Completed N/A Kids Safe and Smokefree (KiSS) March 2012 June 2016
NCT01753141 Completed N/A Smoking Treatment and Anxiety Management Program January 2008 August 2013
NCT01756885 Completed Phase 3 Extended Varenicline Treatment for Smoking Among Cancer Patients January 2013 May 31, 2018
NCT01780038 Completed N/A Smokers' Response to Nicotine Dependence Genotyping November 14, 2012 August 31, 2013
NCT01783912 Completed Phase 4 Helping Those With Mental Illness Quit Smoking December 2012 June 2014
NCT01806779 Completed Phase 2 Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers March 2013 March 2015
NCT01811225 Completed Phase 2 Smoking, Sex Hormones, and Pregnancy December 2012 June 2017
NCT01821560 Completed Phase 2 Baclofen Effects in Cigarette Smokers March 2013 June 2017
NCT01860924 Completed N/A Vigorous Exercise for Depressed Smokers May 2013 December 2015
NCT01876810 Completed Phase 2 Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction February 2014 February 2016
NCT01880099 Completed N/A A Study to Help People Quit Smoking. December 2013 December 2015
NCT01924468 Completed Phase 1 Brain Networks and Addiction Susceptibility August 14, 2013 May 14, 2019
NCT01926626 Completed Phase 2 Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers September 2013 October 2014
NCT01943994 Completed N/A Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study September 2008 November 14, 2023
NCT05852860 Enrolling by invitation N/A A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research December 1, 2023 January 2026
NCT04188873 Enrolling by invitation Phase 4 Cessation Screening Project December 10, 2020 August 1, 2024
NCT06347055 Not yet recruiting N/A NeuroControl of Nicotine Dependence July 15, 2024 April 30, 2030
NCT05962229 Not yet recruiting Phase 1 Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine June 1, 2024 September 2025
NCT05660798 Not yet recruiting N/A Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression January 2, 2023 December 31, 2025
NCT05587361 Not yet recruiting Phase 4 Beta-Adrenergic Modulation of Drug Cue Reactivity June 1, 2024 March 30, 2025
NCT06295757 Not yet recruiting N/A Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures July 1, 2024 January 1, 2027
NCT06027723 Recruiting Early Phase 1 Nicotine and Pavlovian Bias October 25, 2023 October 31, 2024
NCT03904186 Recruiting N/A Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV December 19, 2019 February 28, 2024
NCT06291558 Recruiting N/A Exercise Training for Smoking Students October 1, 2023 October 1, 2024
NCT01036685 Recruiting Cognitive Task Development and Implementation for Functional MRI Studies May 22, 2005
NCT01036581 Recruiting N/A Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging October 24, 2003 December 31, 2029
NCT04738643 Recruiting N/A Improving Tobacco Treatment Rates for Cancer Patients Who Smoke June 28, 2022 May 31, 2024
NCT03968900 Recruiting N/A Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal January 1, 2021 August 1, 2025
NCT03999099 Recruiting Phase 1 Targeting Orexin to Treat Nicotine Dependence September 26, 2019 December 1, 2024
NCT01782599 Recruiting N/A Electronic Cigarettes and Reactivity to Smoking Cues January 2013 October 1, 2024
NCT04449510 Recruiting N/A Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH January 4, 2021 August 31, 2024
NCT05658471 Recruiting N/A Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC) February 1, 2023 January 31, 2025
NCT05903014 Recruiting Phase 4 Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction January 1, 2023 December 30, 2023
NCT06053567 Recruiting Phase 3 Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity. December 27, 2023 June 30, 2028
NCT06077240 Recruiting N/A Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction June 2024 January 2029
NCT04429568 Recruiting N/A THC Crossover Study October 30, 2020 June 30, 2024
NCT05630781 Recruiting N/A Orexin s Role in the Neurobiology of Substance Use Disorder February 15, 2023 December 31, 2027
NCT04231539 Recruiting N/A Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study February 18, 2020 August 18, 2024
NCT02974582 Recruiting N/A Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers July 5, 2024 October 6, 2027
NCT04176172 Recruiting Phase 3 Optimizing Tobacco Use Treatment for PLWHA February 17, 2020 June 30, 2025
NCT05176418 Recruiting Early Phase 1 IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate September 9, 2022 August 1, 2024
NCT03506867 Recruiting N/A A Healthy People Initiative: Building the Socio-Economic Capital of Low Income Population At-Risk for HIV and Hepatitis-C January 3, 2019 March 31, 2027
NCT05515354 Recruiting Phase 4 Smoking Cessation and Menstrual Cycle Phase November 30, 2022 August 31, 2025
NCT01867411 Recruiting Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity November 6, 2013
NCT05513872 Recruiting Phase 1/Phase 2 Overcoming Nicotine Dependence to Enable Quitting February 1, 2023 May 30, 2027
NCT06389266 Recruiting N/A Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia June 15, 2023 January 10, 2029
NCT04974580 Recruiting Phase 4 Research and Innovation to Stop E-cigarette/Vaping in Young Adults July 5, 2021 June 30, 2023
NCT05796791 Recruiting Early Phase 1 Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder May 2, 2023 May 2024
NCT05206435 Recruiting Phase 4 Methadone-Maintained Smokers Switching to E-Cigarettes March 31, 2022 June 30, 2024
NCT05487807 Recruiting Phase 1 Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia September 13, 2023 August 31, 2026
NCT06239350 Recruiting N/A Young Adult Tobacco/Nicotine and Cannabis Co-use May 13, 2024 January 1, 2029
NCT04571216 Recruiting Phase 2 Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy September 1, 2021 December 2024
NCT05430334 Recruiting N/A Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency July 13, 2022 January 31, 2025
NCT01636310 Suspended N/A Multiple Cigarette Induced Changes in Hormone Function, Mood States and Behavior December 2005 December 2016
NCT01636323 Suspended N/A Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors December 2008 December 2016
NCT01636336 Suspended N/A Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects September 2008 December 2016
NCT04602494 Terminated Phase 4 Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents December 18, 2020 June 27, 2022
NCT03213418 Terminated N/A Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment February 1, 2018 December 1, 2022
NCT03248713 Terminated Early Phase 1 Glucocorticoid Antagonist Treatment for Tobacco Use Disorder November 29, 2017 May 20, 2019
NCT01395797 Terminated Phase 1/Phase 2 Pioglitazone for Heroin and for Nicotine Dependence March 2011 June 2014
NCT01411007 Terminated The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues March 2010 February 2016
NCT00508560 Terminated N/A Contingency Management for Smoking Cessation Among Veterans With Psychotic Disorders July 2007 December 2012
NCT00511134 Terminated Phase 4 Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban April 2007 December 2008
NCT01480232 Terminated Phase 2 A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence December 2011 September 2015
NCT03352609 Terminated N/A Accelerated rTMS for the Reduction of Nicotine Craving January 1, 2018 December 12, 2018
NCT02439944 Terminated Phase 2/Phase 3 Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement July 2015 December 2017
NCT01560507 Terminated Phase 2/Phase 3 Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants May 2012 July 2013
NCT01576640 Terminated Phase 4 Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia December 2005 October 2007
NCT01642433 Terminated Phase 2 Prazosin for Smoking Cessation July 2012 September 2013
NCT00257894 Terminated Phase 2 Baclofen Effects on Smoking Urge and Withdrawal December 2005 December 2008
NCT00254358 Terminated A Brain Imaging Study of Nicotine Release in Cigarette Smokers April 2007 April 2007
NCT02599571 Terminated N/A Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers March 30, 2016 September 12, 2019
NCT02665338 Terminated N/A TMS-fMRI for Neural Pathway in Smokers April 28, 2014 June 16, 2015
NCT01040338 Terminated Effects of Nicotine on Brain Opioid Receptors February 2010 March 2011
NCT01842334 Terminated Phase 1/Phase 2 D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS) April 2013 August 2017
NCT02845687 Terminated Study on Smoking Cessation and Cost Outcomes in the Duke Smoking Cessation Program August 16, 2016 May 29, 2018
NCT01169610 Terminated Phase 3 Varenicline and Alcohol in Inpatient Addictions Program (IAP) January 2011 June 2013
NCT01228994 Terminated Phase 2 Baclofen for Smoking Cessation in a Non-Psychiatric Population October 2010 August 2012
NCT03173274 Terminated N/A Incentives to Promote Smoking Cessation in Low SES Women February 8, 2018 March 3, 2018
NCT00390923 Terminated N/A Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence July 2007 April 2008
NCT01892813 Unknown status Phase 3 Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers July 2013 January 2018
NCT01898169 Unknown status N/A Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System April 2013 July 2013
NCT01314378 Unknown status N/A Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers January 2011 October 2012
NCT01182766 Unknown status Phase 2/Phase 3 New Treatment for Alcohol and Nicotine Dependence September 2011 June 2022
NCT01550029 Unknown status N/A Targeted Intervention for Bipolar Smokers July 2010 August 2014
NCT01566097 Unknown status N/A Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation April 2012 July 2015
NCT03165578 Unknown status N/A Neural Correlates of Neurofeedback Training May 1, 2017 September 30, 2020
NCT00456534 Unknown status The Effect of Smoking on Perception November 2006 June 2007
NCT00429208 Unknown status N/A Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers February 2007 April 2007
NCT05434429 Unknown status N/A Mobile Health for Problematic Behaviors and Substance Use June 21, 2022 February 2023
NCT04645914 Unknown status N/A Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation July 2, 2020 December 1, 2022
NCT02635919 Unknown status N/A Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence April 2016 November 2018
NCT00679861 Unknown status Phase 2 Smoking Interventions in General Medical Practices October 2004 June 2009
NCT01965405 Unknown status N/A Smoking Cessation for People Living With HIV/AIDS August 2013 December 2021
NCT02204956 Unknown status N/A Smoking Cessation Following Psychiatric Hospitalization July 2015 June 2019
NCT02994082 Unknown status N/A Treating Smokeless Tobacco Use in Rural Veterans December 2016 May 2020
NCT01784016 Withdrawn Phase 1 Concurrent PET D2/D3 Receptor Imaging and fMRI Smoking Cue Reactivity in Smokers January 2014 May 2014
NCT01784653 Withdrawn Phase 1 Trial of Computerized MET for Adolescent Substance Use October 2013
NCT01784627 Withdrawn Phase 1 Trial of Computerized SBI to Reduce Teen Alcohol Use January 2015 October 2017
NCT04047836 Withdrawn N/A Vaping High vs. Low Nicotine E-Liquid June 1, 2023 December 31, 2023
NCT03707600 Withdrawn N/A State and Trait Mediated Response to TMS in Substance Use Disorder September 27, 2018 June 8, 2020
NCT01589081 Withdrawn N/A Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect September 2008 December 1, 2015
NCT01859364 Withdrawn Tobacco Cessation: Treatment Delivery and Predictors of Outcome April 27, 2013 March 1, 2023
NCT01589068 Withdrawn N/A Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs January 2007 December 1, 2015
NCT01589055 Withdrawn N/A IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior April 2005 December 1, 2015
NCT01569477 Withdrawn N/A Striving to Quit-Wisconsin Tobacco Quit Line September 2012 March 2013
NCT01557556 Withdrawn Pexacerfont to Reduce Stress-induced Tobacco Craving February 24, 2012 December 16, 2013
NCT03473483 Withdrawn N/A Cigarette Harm Reduction With Electronic Cigarette Use August 1, 2022 March 31, 2026
NCT02487953 Withdrawn Phase 2 Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment July 2018 January 2022
NCT03069768 Withdrawn Phase 1 Stage Ib Trial of mSMART With Varenicline April 2018 June 2019
NCT02046551 Withdrawn Phase 1/Phase 2 Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers April 2014 February 2017
NCT00571805 Withdrawn Phase 1/Phase 2 Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt September 2007
NCT01741376 Withdrawn N/A Progesterone and Atomoxetine for Cocaine Cessation November 2012 November 2012
NCT01710410 Withdrawn Phase 2 Transcranial Direct Current Stimulation in a Smoking Cessation Trial October 2016 October 2016
Disase is a (Disease Ontology)
DOID:9973
Cross Reference ID (Disease Ontology)
EFO:0003768
Cross Reference ID (Disease Ontology)
ICD10CM:F17
Cross Reference ID (Disease Ontology)
MESH:D014029
Cross Reference ID (Disease Ontology)
NCI:C54203
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:56294008
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0028043
Exact Synonym (Disease Ontology)
tobacco use disorder