GDC-0879
Information
- Drug Name
- GDC-0879
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer |
BRAF p.Val640Glu (p.V640E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 23549875 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| In a mouse model of BRAF V600E colorectal cancer, ... | BRAF |
BRAF p.Val640Glu (p.V640E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
Sensitivity | true | CIViC Evidence | detail |
| Anti-melanoma efficacy of the novel RAF inhibitor ... | BRAF | BRAF V600E | Sensitivity | true | MMMP | detail |