chr4:153242410:> Detail (hg19) (FBXW7)

Information

Genome

Assembly Position
hg19 chr4:153,242,410-153,457,253
hg38 chr4:152,321,258-152,536,101 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
renal cell carcinoma Everolimus E Predictive Supports Sensitivity/Response N/A 2 24253377 Detail
cancer Sirolimus D Predictive Supports Sensitivity/Response Somatic 4 18787170 Detail
DisGeNET
[No Data.]
Annotation

Annotations

DescrptionSourceLinks
mTOR protein levels were found to underly a circadian 24-hour rhythm regulated by time-dependent Fbx... CIViC Evidence Detail
FBXW7 was shown to target mTOR for ubiquitination and degradation. A reciprocal relationship betwee... CIViC Evidence Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
Genome
hg19
Position
chr4:153,242,410-153,457,253
Variant Type
snv
Variant (CIViC) (CIViC Variant)
LOSS-OF-FUNCTION
Transcript 1 (CIViC Variant)
ENST00000281708.4
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/637
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