chr4:38822897:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr4:38,824,518-38,858,438 |
| hg38 | chr4:38,822,897-38,856,817 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.002 | chorioamnionitis | NA | GAD | Detail | |
| <0.001 | colitis | Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastroi... | BeFree | 24670426 | Detail |
| 0.003 | ulcerative colitis | NA | BeFree,GAD | Detail | |
| 0.002 | Crohn Disease | NA | GAD | Detail | |
| 0.002 | cystitis | NA | GAD | Detail | |
| 0.003 | Dermatitis, Atopic | NA | BeFree,GAD | Detail | |
| <0.001 | Diabetes Mellitus, Insulin-Dependent | Our study, for the first time, indicates that TLR1 and TLR6 gene might play impo... | BeFree | 25261617 | Detail |
| <0.001 | Eczema | NA | BeFree | Detail | |
| <0.001 | endometritis | NA | BeFree | Detail | |
| 0.002 | Fetal Membranes, Premature Rupture | NA | GAD | Detail | |
| <0.001 | Graves Disease | Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. | BeFree | 25028161 | Detail |
| <0.001 | HIV Infections | NA | BeFree | Detail | |
| 0.002 | Hypersensitivity | NA | GAD | Detail | |
| 0.002 | Immediate hypersensitivity | NA | GAD | Detail | |
| 0.003 | Hypertensive disease | NA | BeFree,GAD | Detail | |
| 0.090 | Inflammation | NA | GAD,LHGDN,RGD | Detail | |
| <0.001 | Inflammatory Bowel Diseases | These results demonstrate that TLR6 supports Th1- and Th17-skewed responses in t... | BeFree | 24670426 | Detail |
| 0.002 | Premature Obstetric Labor | NA | GAD | Detail | |
| <0.001 | Legionnaires' disease | NA | BeFree | Detail | |
| <0.001 | Leukemia, Lymphocytic, Acute, L1 | NA | BeFree | Detail | |
| 0.003 | Chronic Obstructive Airway Disease | NA | BeFree,GAD | Detail | |
| <0.001 | Tuberculosis, Pulmonary | In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile... | BeFree | 20797905 | Detail |
| 0.002 | Lyme disease | NA | GAD | Detail | |
| 0.005 | Lymphoma, Non-Hodgkin | NA | BeFree,GAD | Detail | |
| 0.003 | malaria | NA | BeFree,GAD | Detail | |
| 0.002 | multiple myeloma | NA | GAD | Detail | |
| 0.002 | multiple sclerosis | NA | GAD | Detail | |
| <0.001 | Mycoses | NA | BeFree | Detail | |
| <0.001 | Neurosyphilis | A common TLR1 polymorphism is associated with an increased risk of laboratory-de... | BeFree | 24922103 | Detail |
| <0.001 | Osteitis | The TLR2 and TLR6 variant genotypes were associated with a higher risk of BCG os... | BeFree | 25605403 | Detail |
| 0.002 | pre-eclampsia | NA | GAD | Detail | |
| 0.002 | Pregnancy Complications, Infectious | NA | GAD | Detail | |
| <0.001 | proctitis | NA | BeFree | Detail | |
| 0.125 | Prostatic Neoplasms | NA | CTD_human,LHGDN | Detail | |
| 0.002 | Puerperal Disorders | NA | GAD | Detail | |
| 0.002 | pyelonephritis | NA | GAD | Detail | |
| 0.005 | Respiratory Syncytial Virus Infections | NA | GAD | Detail | |
| 0.002 | Streptococcal Infections | NA | GAD | Detail | |
| <0.001 | syphilis | Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G... | BeFree | 24922103 | Detail |
| 0.005 | tuberculosis | Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polym... | BeFree,GAD | 24984237 | Detail |
| 0.005 | tuberculosis | Age-genotype interaction analysis revealed SNPs in IL18 and TLR6 that were sugge... | BeFree,GAD | 25521228 | Detail |
| <0.001 | Tuberculosis, Pulmonary | NA | BeFree | Detail | |
| 0.002 | urinary tract infection | NA | GAD | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| 0.002 | Bronchial Hyperreactivity | NA | GAD | Detail | |
| 0.003 | bacterial vaginosis | NA | BeFree,GAD | Detail | |
| <0.001 | Polyendocrinopathies, Autoimmune | Blocking experiments with specific neutralizing antibodies for TLR1, TLR6, and C... | BeFree | 26195551 | Detail |
| 0.002 | Gram-Positive Bacterial Infections | NA | GAD | Detail | |
| 0.002 | Premature Birth | NA | GAD | Detail | |
| <0.001 | invasive aspergillosis | NA | BeFree | Detail | |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| <0.001 | pelvic inflammatory disease | NA | BeFree | Detail | |
| <0.001 | Mucosa-Associated Lymphoid Tissue Lymphoma | NA | BeFree | Detail | |
| 0.003 | Parasitemia | NA | BeFree,GAD | Detail | |
| 0.005 | Sepsis | NA | GAD | Detail | |
| 0.016 | Malignant neoplasm of prostate | NA | BeFree,GAD | Detail | |
| <0.001 | Non-alcoholic Fatty Liver Disease | Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of ... | BeFree | 24351080 | Detail |
| 0.080 | Necrotizing Enterocolitis | NA | RGD | Detail | |
| 0.001 | prostate carcinoma | NA | BeFree | Detail | |
| 0.002 | Pancolitis | NA | GAD | Detail | |
| <0.001 | Asthma chronic | NA | BeFree | Detail | |
| <0.001 | Marginal Zone B-Cell Lymphoma | NA | BeFree | Detail | |
| <0.001 | Allergic rhinitis (disorder) | Three SNPs located in the TLR6-TLR1 locus had the lowest P-values and Q-values <... | BeFree | 25066275 | Detail |
| 0.002 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | NA | GAD | Detail | |
| 0.003 | Infection | NA | LHGDN | Detail | |
| <0.001 | acute pancreatitis | Our article points to genetic polymorphisms in TLR3 and TLR6 as having a plausib... | BeFree | 25423559 | Detail |
| 0.003 | Anoxia | NA | LHGDN | Detail | |
| 0.002 | rheumatoid arthritis | NA | GAD | Detail | |
| 0.005 | aspergillosis | NA | GAD,LHGDN | Detail | |
| 0.021 | asthma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.080 | Pneumonia, Bacterial | NA | RGD | Detail | |
| <0.001 | borderline personality disorder | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of breast | NA | GAD | Detail | |
| 0.002 | bronchiolitis obliterans | NA | GAD | Detail | |
| 0.002 | Bronchiolitis, Viral | NA | GAD | Detail | |
| <0.001 | bronchopulmonary dysplasia | NA | BeFree | Detail | |
| 0.002 | candidiasis | NA | GAD | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our study, for the first time, indicates that TLR1 and TLR6 gene might play important roles in the e... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These results demonstrate that TLR6 supports Th1- and Th17-skewed responses in the GALT and might be... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A common TLR1 polymorphism is associated with an increased risk of laboratory-defined neurosyphilis,... | DisGeNET | Detail |
| The TLR2 and TLR6 variant genotypes were associated with a higher risk of BCG osteitis, with adjuste... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms in the genes for TLR1 (a T→G mutation at position 1805), TLR2 (a G→A mutation at posit... | DisGeNET | Detail |
| Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tubercul... | DisGeNET | Detail |
| Age-genotype interaction analysis revealed SNPs in IL18 and TLR6 that were suggestively associated w... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Blocking experiments with specific neutralizing antibodies for TLR1, TLR6, and CD14 showed that TLR6... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-al... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Three SNPs located in the TLR6-TLR1 locus had the lowest P-values and Q-values < 0.1 when using a we... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Our article points to genetic polymorphisms in TLR3 and TLR6 as having a plausible role in the occur... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386502799 dbSNP
- Genome
- hg38
- Position
- chr4:38,822,897-38,856,817
- Variant Type
- snv
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