chr7:128241278:> Detail (hg38)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:127,881,331-127,897,682 |
| hg38 | chr7:128,241,278-128,257,629 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| 0.003 | squamous cell carcinoma | The incidence of leptin gene G2548A homozygous mutant AA polymorphism was signif... | BeFree,GAD | 25809704 | Detail |
| 0.010 | Cardiovascular Diseases | Leptin, a possible mediator between energy homeostasis, inflammation and cardiov... | BeFree,GAD,LHGDN | 25296580 | Detail |
| <0.001 | Transient ischemic attack | NA | BeFree | Detail | |
| <0.001 | cholera | NA | BeFree | Detail | |
| 0.002 | chorioamnionitis | NA | GAD | Detail | |
| 0.004 | choriocarcinoma | NA | BeFree,LHGDN | Detail | |
| 0.003 | Churg-Strauss syndrome | NA | BeFree,GAD | Detail | |
| 0.003 | Cognition Disorders | NA | LHGDN | Detail | |
| 0.003 | ulcerative colitis | NA | BeFree,LHGDN | Detail | |
| 0.128 | Colonic Neoplasms | CA supplementation in vivo decreased the number of colon tumors and reduced circ... | BeFree,CTD_human,GAD,LHGDN | 25204550 | Detail |
| 0.004 | colorectal carcinoma | NA | BeFree | Detail | |
| 0.003 | Colorectal Neoplasms | NA | LHGDN | Detail | |
| <0.001 | Coronary Arteriosclerosis | Association of leptin levels with pathogenetic risk of coronary heart disease an... | BeFree | 25465603 | Detail |
| 0.006 | Coronary heart disease | Association of leptin levels with pathogenetic risk of coronary heart disease an... | BeFree,LHGDN | 25465603 | Detail |
| 0.121 | Crohn Disease | NA | BeFree,CTD_human | Detail | |
| <0.001 | Cushing syndrome | In patients with Cushing's syndrome leptin mRNA levels were significantly higher... | BeFree | 25313911 | Detail |
| 0.003 | Mental Depression | Recently, a biological link between leptin resistance and depression has been pr... | BeFree,GAD | 25629253 | Detail |
| 0.001 | depressive disorder | Recently, a biological link between leptin resistance and depression has been pr... | BeFree | 25629253 | Detail |
| 0.008 | Diabetes | In the prospective Pune Maternal Nutrition Study, we found that small and thin I... | BeFree | 25059801 | Detail |
| 0.012 | diabetes mellitus | In the prospective Pune Maternal Nutrition Study, we found that small and thin I... | BeFree,LHGDN | 25059801 | Detail |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.010 | Diabetes Mellitus, Insulin-Dependent | NA | BeFree,GAD | Detail | |
| 0.321 | Diabetes Mellitus, Non-Insulin-Dependent | Functional polymorphisms of the leptin and leptin receptor genes are associated ... | BeFree,CTD_human,GAD,LHGDN,MGD,RGD | 24549597 | Detail |
| <0.001 | Diabetic Nephropathy | NA | BeFree | Detail | |
| <0.001 | diverticulitis | NA | BeFree | Detail | |
| <0.001 | Down syndrome | NA | BeFree | Detail | |
| <0.001 | Drug abuse | NA | BeFree | Detail | |
| <0.001 | Dwarfism | NA | BeFree | Detail | |
| 0.003 | Dysautonomia | NA | LHGDN | Detail | |
| <0.001 | dysentery | NA | BeFree | Detail | |
| 0.001 | Eating Disorders | NA | BeFree | Detail | |
| 0.003 | eclampsia | NA | BeFree | Detail | |
| <0.001 | Experimental Autoimmune Encephalomyelitis | NA | BeFree | Detail | |
| <0.001 | Endocrine System Diseases | NA | BeFree | Detail | |
| 0.002 | Endometrial Neoplasms | NA | GAD | Detail | |
| 0.012 | endometriosis | NA | BeFree,LHGDN | Detail | |
| <0.001 | External exotoses | NA | BeFree | Detail | |
| 0.131 | Fatty Liver | Leptin improves fatty liver independently of insulin sensitization and appetite ... | BeFree,CTD_human,GAD,LHGDN | 25415231 | Detail |
| 0.083 | Fetal Growth Retardation | NA | LHGDN,RGD | Detail | |
| 0.002 | Fetal Membranes, Premature Rupture | NA | GAD | Detail | |
| <0.001 | gastritis | NA | BeFree | Detail | |
| <0.001 | Gastritis, Atrophic | NA | BeFree | Detail | |
| <0.001 | glioblastoma | NA | BeFree | Detail | |
| <0.001 | Glioma | NA | BeFree | Detail | |
| <0.001 | Heart Diseases | NA | BeFree | Detail | |
| 0.003 | Heart failure | NA | BeFree,GAD | Detail | |
| 0.001 | congestive heart failure | NA | BeFree | Detail | |
| <0.001 | hemangioma | NA | BeFree | Detail | |
| <0.001 | hepatitis | NA | BeFree | Detail | |
| <0.001 | hepatitis A | NA | BeFree | Detail | |
| 0.001 | hepatitis C | NA | BeFree | Detail | |
| 0.120 | heroin dependence | NA | CTD_human | Detail | |
| 0.003 | HIV Infections | NA | BeFree,LHGDN | Detail | |
| <0.001 | Hodgkin Disease | NA | BeFree | Detail | |
| 0.002 | Hunger | NA | BeFree | Detail | |
| 0.083 | Huntington disease | NA | BeFree,LHGDN,RGD | Detail | |
| <0.001 | Hydatidiform mole | NA | BeFree | Detail | |
| 0.120 | Hypercholesterolemia | NA | BeFree,CTD_human | Detail | |
| 0.002 | hyperglycemia | Black and tan, brachyury (BTBR) mice deficient for the leptin receptor (ob/ob) d... | BeFree | 25034792 | Detail |
| 0.135 | hyperinsulinism | NA | BeFree,CTD_human,LHGDN | Detail | |
| 0.081 | Hyperlipidemia | NA | BeFree,RGD | Detail | |
| <0.001 | Hyperlipidemia, Familial Combined | NA | BeFree | Detail | |
| <0.001 | hyperparathyroidism | NA | BeFree | Detail | |
| 0.122 | Hyperphagia | We now describe two siblings, a 9-year-old girl and a 6-year-old boy with severe... | BeFree,CTD_human | 26186301 | Detail |
| 0.003 | Hyperplasia | NA | LHGDN | Detail | |
| 0.240 | Hypertensive disease | When leptin and leptin receptor genes were considered together, synergistic inte... | BeFree,CTD_human,GAD,LHGDN,RGD | 24171506 | Detail |
| 0.240 | Hypertensive disease | Association of two well-defined polymorphisms in leptin and leptin receptor gene... | BeFree,CTD_human,GAD,LHGDN,RGD | 25475696 | Detail |
| <0.001 | pulmonary hypertension | Importantly, we demonstrate the efficacy of two curative strategies using a solu... | BeFree | 25745038 | Detail |
| <0.001 | hyperthyroidism | NA | BeFree | Detail | |
| 0.201 | hypogonadism | NA | BeFree,CTD_human,RGD | Detail | |
| 0.003 | hypothyroidism | NA | BeFree,LHGDN | Detail | |
| <0.001 | Immunologic Deficiency Syndromes | NA | BeFree | Detail | |
| 0.001 | Immune System Diseases | NA | BeFree | Detail | |
| 0.003 | infertility | NA | LHGDN | Detail | |
| 0.120 | Female infertility | NA | CTD_human | Detail | |
| 0.139 | Inflammation | NA | CTD_human,LHGDN | Detail | |
| <0.001 | Inflammatory Bowel Diseases | NA | BeFree | Detail | |
| <0.001 | influenza | NA | BeFree | Detail | |
| 0.202 | Insulin resistance | NA | CTD_human,GAD,RGD | Detail | |
| <0.001 | insulinoma | NA | BeFree | Detail | |
| <0.001 | ischemia | NA | BeFree | Detail | |
| 0.006 | Kidney Diseases | Leptin is also involved in the progression of renal disease through its pro-fibr... | BeFree,GAD,LHGDN | 25010649 | Detail |
| 0.008 | Kidney Failure, Chronic | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Klinefelter syndrome | NA | BeFree | Detail | |
| 0.002 | Premature Obstetric Labor | NA | GAD | Detail | |
| <0.001 | Lethargy | NA | BeFree | Detail | |
| 0.001 | leukemia | NA | BeFree | Detail | |
| <0.001 | Acute Erythroblastic Leukemia | Therefore, have investigated whether or not the expression levels, of selected g... | BeFree | 24961464 | Detail |
| <0.001 | Acute lymphocytic leukemia | NA | BeFree | Detail | |
| <0.001 | Leukemia, Lymphocytic, Acute, L1 | NA | BeFree | Detail | |
| 0.004 | Leukemia, Myelocytic, Acute | NA | BeFree,LHGDN | Detail | |
| <0.001 | Myeloid Leukemia, Chronic | Imatinib itself may increase leptin levels, and, as leptin plays an active role ... | BeFree | 25648025 | Detail |
| 0.009 | lipodystrophy | Therapeutic management of dyslipidemia in patients with lipodystrophy is primari... | BeFree,LHGDN | 25047893 | Detail |
| <0.001 | lipoma | NA | BeFree | Detail | |
| <0.001 | liposarcoma | NA | BeFree | Detail | |
| 0.005 | liver cirrhosis | NA | LHGDN | Detail | |
| 0.003 | Biliary cirrhosis | NA | LHGDN | Detail | |
| 0.200 | Liver Cirrhosis, Experimental | NA | CTD_human,RGD | Detail | |
| 0.003 | Liver diseases | NA | BeFree,GAD | Detail | |
| 0.002 | Liver neoplasms | In the present study, we investigated the role of autophagy in leptin-induced ca... | BeFree | 25704884 | Detail |
| 0.006 | Chronic Obstructive Airway Disease | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | Lung Neoplasms | NA | LHGDN | Detail | |
| 0.004 | Lupus Erythematosus, Systemic | Serum leptin levels, leptin receptor gene (LEPR) polymorphism, and the risk of s... | BeFree,LHGDN | 25383655 | Detail |
| <0.001 | lupus nephritis | The expression of adiponectin and resistin was increased in both sera and urine ... | BeFree | 25345756 | Detail |
| 0.008 | lymphoma | NA | BeFree,GAD | Detail | |
| <0.001 | Lymphoma, Follicular | Also, our results provide evidence that LEP A19G polymorphism is associated with... | BeFree | 25778326 | Detail |
| 0.003 | Lymphoma, Non-Hodgkin | LEP and LEPR polymorphisms in non-Hodgkin lymphoma risk: a systematic review and... | BeFree,GAD | 25778326 | Detail |
| <0.001 | Malabsorption Syndrome | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of stomach | NA | BeFree | Detail | |
| 0.002 | Animal Mammary Neoplasms | NA | GAD | Detail | |
| 0.080 | Mammary Neoplasms, Experimental | NA | RGD | Detail | |
| <0.001 | melanoma | NA | BeFree | Detail | |
| <0.001 | premature menopause | NA | BeFree | Detail | |
| 0.006 | Metabolic Diseases | NA | BeFree,LHGDN | Detail | |
| <0.001 | Mixed Salivary Gland Tumor | NA | BeFree | Detail | |
| 0.002 | Mouth Neoplasms | NA | GAD | Detail | |
| <0.001 | multiple myeloma | NA | BeFree | Detail | |
| 0.003 | multiple sclerosis | NA | BeFree,GAD | Detail | |
| <0.001 | muscular dystrophy | NA | BeFree | Detail | |
| <0.001 | myocardial infarction | Functional polymorphisms of the leptin and leptin receptor genes are associated ... | BeFree | 24549597 | Detail |
| 0.080 | Myocardial Reperfusion Injury | NA | RGD | Detail | |
| 0.003 | myoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | Myotonic dystrophy | NA | BeFree | Detail | |
| <0.001 | narcolepsy | NA | BeFree | Detail | |
| <0.001 | Nasal Polyps | NA | BeFree | Detail | |
| 0.010 | Neoplasm Metastasis | Leptin and ObR are overexpressed in EC, and their expressions are associated wit... | BeFree,LHGDN | 25171477 | Detail |
| 0.002 | Pathologic Neovascularization | NA | GAD | Detail | |
| 0.005 | nephrotic syndrome | NA | LHGDN | Detail | |
| 0.120 | Nerve Degeneration | NA | CTD_human | Detail | |
| <0.001 | neuroblastoma | NA | BeFree | Detail | |
| 0.128 | Obesity, Morbid | Among 73 children with severe obesity (BMI SDS > 3.0), we identified 22 probands... | BeFree,CTD_human,GAD | 26179253 | Detail |
| 0.005 | Degenerative polyarthritis | Therefore, in the present study, we investigated the hypothesis that hypoxia may... | BeFree,LHGDN | 25312721 | Detail |
| 0.081 | osteoporosis | NA | BeFree,RGD | Detail | |
| 0.001 | ovarian carcinoma | NA | BeFree | Detail | |
| 0.003 | Ovarian Diseases | NA | BeFree | Detail | |
| 0.080 | Parkinson disease | NA | RGD | Detail | |
| <0.001 | Parotid Neoplasms | NA | BeFree | Detail | |
| 0.001 | pituitary adenoma | NA | BeFree | Detail | |
| 0.005 | Pituitary Diseases | NA | BeFree | Detail | |
| <0.001 | Pituitary Neoplasms | NA | BeFree | Detail | |
| 0.003 | placental insufficiency | NA | BeFree,LHGDN | Detail | |
| 0.137 | polycystic ovary syndrome | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| <0.001 | Adenomatous Polyposis Coli | NA | BeFree | Detail | |
| 0.120 | Polyuria | NA | BeFree,CTD_human | Detail | |
| 0.002 | Prader-Willi syndrome | NA | BeFree | Detail | |
| 0.103 | pre-eclampsia | NA | GAD,LHGDN,RGD | Detail | |
| <0.001 | Precancerous Conditions | NA | BeFree | Detail | |
| 0.003 | Pregnancy Complications | NA | LHGDN | Detail | |
| 0.002 | Pregnancy Complications, Cardiovascular | NA | GAD | Detail | |
| 0.005 | Pregnancy in Diabetics | NA | BeFree,GAD | Detail | |
| 0.128 | Prostatic Neoplasms | NA | CTD_human,LHGDN | Detail | |
| 0.120 | proteinuria | NA | CTD_human | Detail | |
| 0.003 | psoriasis | NA | BeFree,LHGDN | Detail | |
| <0.001 | Psychotic Disorders | NA | BeFree | Detail | |
| <0.001 | pyruvate carboxylase deficiency disease | NA | BeFree | Detail | |
| <0.001 | kidney failure | NA | BeFree | Detail | |
| 0.080 | Reperfusion Injury | NA | RGD | Detail | |
| <0.001 | retinoblastoma | NA | BeFree | Detail | |
| 0.003 | Rett syndrome | Notably, patients with RTT have evidence of mitochondrial dysfunction, as well a... | BeFree,LHGDN | 25299635 | Detail |
| 0.009 | schizophrenia | We investigated the associations of the LEP-2548A/G and HTR2C-759C/T polymorphis... | BeFree,GAD,LHGDN | 25304226 | Detail |
| 0.003 | Scoliosis, unspecified | NA | LHGDN | Detail | |
| 0.121 | Seizures | NA | BeFree,CTD_human | Detail | |
| <0.001 | Septicemia | NA | BeFree | Detail | |
| 0.080 | short bowel syndrome | NA | RGD | Detail | |
| <0.001 | Sleep disturbances | NA | BeFree | Detail | |
| 0.003 | ankylosing spondylitis | NA | BeFree,LHGDN | Detail | |
| 0.003 | Starvation | NA | LHGDN | Detail | |
| 0.005 | Stomach Neoplasms | NA | LHGDN | Detail | |
| 0.120 | gastric ulcer | NA | CTD_human | Detail | |
| <0.001 | Stress, Psychological | NA | BeFree | Detail | |
| <0.001 | Cerebrovascular accident | Association of leptin levels with pathogenetic risk of coronary heart disease an... | BeFree | 25465603 | Detail |
| 0.120 | Tachycardia | NA | CTD_human | Detail | |
| 0.003 | thrombosis | NA | LHGDN | Detail | |
| <0.001 | Thyroid Diseases | NA | BeFree | Detail | |
| <0.001 | Attention Deficit Disorder | NA | BeFree | Detail | |
| 0.003 | uremia | NA | BeFree,LHGDN | Detail | |
| <0.001 | Uterine Fibroids | NA | BeFree | Detail | |
| 0.002 | Uterine Neoplasms | NA | GAD | Detail | |
| 0.003 | Vascular Diseases | NA | LHGDN | Detail | |
| 0.003 | Venous Thrombosis | NA | LHGDN | Detail | |
| 0.139 | Weight Gain | NA | CTD_human,GAD | Detail | |
| <0.001 | B-Cell Lymphomas | NA | BeFree | Detail | |
| <0.001 | diffuse large B-cell lymphoma | NA | BeFree | Detail | |
| <0.001 | Lymphoma, Large-Cell, Follicular | NA | BeFree | Detail | |
| 0.003 | ovarian hyperstimulation syndrome | NA | LHGDN | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| 0.131 | gestational diabetes | GO terms relevant to translation and metabolic process and their related genes C... | BeFree,CTD_human,LHGDN | 25736406 | Detail |
| 0.002 | essential hypertension | Evaluation of leptin and leptin receptor gene 3' UTR polymorphisms in essential ... | BeFree | 24171506 | Detail |
| 0.002 | essential hypertension | Our findings support the contributory role of the II/I polymorphism in leptin ge... | BeFree | 25475696 | Detail |
| 0.120 | Polydipsia | NA | CTD_human | Detail | |
| <0.001 | Burning sensation | NA | BeFree | Detail | |
| <0.001 | acute leukemia | NA | BeFree | Detail | |
| <0.001 | Alcohol abuse | NA | BeFree | Detail | |
| <0.001 | Depressive Symptoms | Is there a role for leptin in the reduction of depression symptoms during weight... | BeFree | 25629253 | Detail |
| 0.003 | Pancreatitis, Chronic | NA | LHGDN | Detail | |
| 0.120 | Oral Ulcer | NA | CTD_human | Detail | |
| 0.002 | Premature Birth | NA | GAD | Detail | |
| <0.001 | Disorder of pregnancy | NA | BeFree | Detail | |
| <0.001 | Arterial thrombosis | NA | BeFree | Detail | |
| <0.001 | Idiopathic pulmonary hypertension | We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti... | BeFree | 25745038 | Detail |
| <0.001 | Malignant neoplasm of mouth | NA | BeFree | Detail | |
| 0.002 | Malnutrition | The significance of this work thus extends beyond understanding E. histolytica s... | BeFree | 25516614 | Detail |
| 0.003 | HELLP syndrome | NA | BeFree,GAD | Detail | |
| 0.003 | Aortic Aneurysm, Abdominal | NA | LHGDN | Detail | |
| <0.001 | Glomerulosclerosis (disorder) | Black and tan, brachyury (BTBR) mice deficient for the leptin receptor (ob/ob) d... | BeFree | 25034792 | Detail |
| 0.002 | Tumor Progression | Interestingly, inhibition of autophagic process by treatment with inhibitors and... | BeFree | 25704884 | Detail |
| <0.001 | Liposarcoma, Pleomorphic | NA | BeFree | Detail | |
| <0.001 | Diabetic Foot | NA | BeFree | Detail | |
| <0.001 | Lip and oral cavity carcinoma | NA | BeFree | Detail | |
| <0.001 | Congenital hypoplasia of adrenal gland | NA | BeFree | Detail | |
| <0.001 | Acquired partial lipodystrophy | NA | BeFree | Detail | |
| 0.001 | Familial generalized lipodystrophy | NA | BeFree | Detail | |
| <0.001 | Chronic schizophrenia | Polymorphisms of the leptin and HTR2C genes and clozapine-induced weight change ... | BeFree | 25304226 | Detail |
| <0.001 | Nose symptoms | NA | BeFree | Detail | |
| <0.001 | Decrease in appetite | NA | BeFree | Detail | |
| <0.001 | Sore to touch | NA | BeFree | Detail | |
| <0.001 | congenital diaphragmatic hernia | NA | BeFree | Detail | |
| <0.001 | Alcohol withdrawal syndrome | DNA methylation of the LEP gene is associated with craving during alcohol withdr... | BeFree | 25462909 | Detail |
| <0.001 | Papillary thyroid carcinoma | NA | BeFree | Detail | |
| 0.001 | Fibrosis, Liver | NA | BeFree | Detail | |
| <0.001 | Liver mass | NA | BeFree | Detail | |
| 0.120 | Hepatitis, Autoimmune | NA | CTD_human | Detail | |
| 0.003 | Biliary calculi | NA | LHGDN | Detail | |
| 0.009 | Dyslipidemias | Therapeutic management of dyslipidemia in patients with lipodystrophy is primari... | BeFree,GAD,LHGDN | 25047893 | Detail |
| 0.006 | Malignant neoplasm of lung | NA | BeFree,GAD | Detail | |
| 0.080 | Sepsis | NA | BeFree,RGD | Detail | |
| <0.001 | parathyroid adenoma | NA | BeFree | Detail | |
| <0.001 | Congenital hypoplasia of lung | NA | BeFree | Detail | |
| <0.001 | Endometrioma | NA | BeFree | Detail | |
| 0.001 | Somatotropin deficiency | NA | BeFree | Detail | |
| <0.001 | hypogonadotropic hypogonadism | NA | BeFree | Detail | |
| 0.001 | Impaired glucose tolerance | NA | BeFree | Detail | |
| <0.001 | familial partial lipodystrophy | NA | BeFree | Detail | |
| <0.001 | Rabson-Mendenhall syndrome | NA | BeFree | Detail | |
| <0.001 | Parathyroid hyperplasia | NA | BeFree | Detail | |
| <0.001 | Carcinoma breast stage IV | NA | BeFree | Detail | |
| <0.001 | Liver and Intrahepatic Biliary Tract Carcinoma | NA | BeFree | Detail | |
| <0.001 | Adenocarcinoma Of Esophagus | NA | BeFree | Detail | |
| <0.001 | Obesity, Abdominal | NA | BeFree | Detail | |
| <0.001 | Restenosis | NA | BeFree | Detail | |
| <0.001 | Healing ulcer | NA | BeFree | Detail | |
| <0.001 | Senile Plaques | NA | BeFree | Detail | |
| <0.001 | Impaired cognition | NA | BeFree | Detail | |
| <0.001 | Thyroid associated opthalmopathies | NA | BeFree | Detail | |
| <0.001 | Aortic aneurysm without mention of rupture NOS | NA | BeFree | Detail | |
| 0.001 | Hypothalamic amenorrhea | NA | BeFree | Detail | |
| <0.001 | Constitutional delay of growth and puberty | NA | BeFree | Detail | |
| <0.001 | Precocious Puberty, Central | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of liver | NA | BeFree | Detail | |
| <0.001 | Growth Hormone-Secreting Pituitary Adenoma | NA | BeFree | Detail | |
| <0.001 | Chronic superficial gastritis | NA | BeFree | Detail | |
| <0.001 | Nonorganic psychosis | NA | BeFree | Detail | |
| <0.001 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | NA | BeFree | Detail | |
| <0.001 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | Leptin Is Oversecreted by Respiratory Syncytial Virus-Infected Bronchial Epithel... | BeFree | 26184438 | Detail |
| 0.009 | Malignant neoplasm of prostate | NA | BeFree,GAD | Detail | |
| <0.001 | Hematopoietic Neoplasms | NA | BeFree | Detail | |
| 0.005 | Immune thrombocytopenic purpura | NA | LHGDN | Detail | |
| 0.121 | Non-alcoholic Fatty Liver Disease | NA | BeFree,CTD_human | Detail | |
| <0.001 | Chronic Kidney Insufficiency | Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. | BeFree | 25010649 | Detail |
| 0.003 | Osteoarthritis, Knee | NA | BeFree,GAD | Detail | |
| <0.001 | Congenital Myotonic Dystrophy | NA | BeFree | Detail | |
| <0.001 | Gastrointestinal symptom | NA | BeFree | Detail | |
| <0.001 | Klinefelter's syndrome - male with more than two X chromosomes | NA | BeFree | Detail | |
| 0.002 | endometrial carcinoma | Correlation analysis between the expressions of leptin and its receptor (ObR) an... | BeFree | 25171477 | Detail |
| 0.011 | Overweight | NA | BeFree,GAD | Detail | |
| 0.005 | body mass | NA | GAD | Detail | |
| <0.001 | Chronic active hepatitis | NA | BeFree | Detail | |
| 0.008 | Sleep Apnea, Obstructive | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Peritoneal Fibrosis | NA | BeFree | Detail | |
| 0.217 | Metabolic syndrome X | Here we examined the correlation between obesity and insulin resistance with the... | BeFree,CTD_human,GAD,RGD | 24549138 | Detail |
| 0.217 | Metabolic syndrome X | Expression of leptin, NGF and adiponectin in metabolic syndrome. | BeFree,CTD_human,GAD,RGD | 25916157 | Detail |
| 0.217 | Metabolic syndrome X | The available relatives of the same family were interviewed (DSM-IV-R) and asses... | BeFree,CTD_human,GAD,RGD | 26083812 | Detail |
| 0.001 | Hepatitis C, Chronic | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of esophagus | NA | GAD | Detail | |
| 0.440 | obesity | Association of the Ala16Val MnSOD gene polymorphism with plasma leptin levels an... | BeFree | 25958349 | Detail |
| <0.001 | Carotid Atherosclerosis | NA | BeFree | Detail | |
| 0.008 | Carcinogenesis | NA | BeFree | Detail | |
| 0.002 | prostate carcinoma | NA | BeFree | Detail | |
| 0.080 | Choroidal Neovascularization | NA | RGD | Detail | |
| <0.001 | Epithelial ovarian cancer | NA | BeFree | Detail | |
| 0.018 | breast carcinoma | These preliminary findings may support the hypothesis that genetic variation in ... | BeFree | 24825736 | Detail |
| 0.018 | breast carcinoma | Signal transducer and activator of transcription 3 (STAT3) has been linked to br... | BeFree | 25481644 | Detail |
| 0.018 | breast carcinoma | Leptin induces SK1 expression and activation in ER-negative breast cancer cell l... | BeFree | 25482303 | Detail |
| 0.018 | breast carcinoma | The LEP G-2548A gene polymorphism is associated with age at menarche and breast ... | BeFree | 25510398 | Detail |
| 0.018 | breast carcinoma | In the present study, we investigated the role of autophagy in leptin-induced ca... | BeFree | 25704884 | Detail |
| 0.001 | Carcinoma of lung | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of gastrointestinal tract | NA | BeFree | Detail | |
| 0.002 | Secondary malignant neoplasm of lymph node | The percentages of leptin and ObR were significantly higher in the patients with... | BeFree | 25171477 | Detail |
| 0.002 | colon carcinoma | NA | BeFree | Detail | |
| 0.002 | stomach carcinoma | NA | BeFree | Detail | |
| <0.001 | Central neuroblastoma | NA | BeFree | Detail | |
| <0.001 | Diabetic peripheral neuropathy | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of kidney | NA | BeFree | Detail | |
| <0.001 | Premenopausal breast cancer | NA | BeFree | Detail | |
| <0.001 | Hypothalamic Dysfunction Syndromes | NA | BeFree | Detail | |
| <0.001 | Narcolepsy-Cataplexy Syndrome | NA | BeFree | Detail | |
| 0.003 | Multiple Sclerosis, Relapsing-Remitting | NA | BeFree,LHGDN | Detail | |
| <0.001 | Bardet-Biedl syndrome | NA | BeFree | Detail | |
| <0.001 | Viral hepatitis, type G | NA | BeFree | Detail | |
| <0.001 | Helicobacter pylori infection | NA | BeFree | Detail | |
| <0.001 | Sleep Disorders | NA | BeFree | Detail | |
| 0.005 | Pregnancy associated hypertension | NA | GAD,LHGDN | Detail | |
| <0.001 | Invasive breast carcinoma | NA | BeFree | Detail | |
| <0.001 | Diabetic Cardiomyopathies | NA | BeFree | Detail | |
| <0.001 | Advanced cancer | NA | BeFree | Detail | |
| 0.002 | Microsatellite Instability | NA | GAD | Detail | |
| <0.001 | Acute coronary syndrome | NA | BeFree | Detail | |
| 0.002 | coronary restenosis | NA | GAD | Detail | |
| 0.120 | Arthritis, Experimental | NA | CTD_human | Detail | |
| <0.001 | Gestational Trophoblastic Neoplasms | NA | BeFree | Detail | |
| 0.001 | Malignant neoplasm of ovary | NA | BeFree | Detail | |
| <0.001 | Ductal Carcinoma | NA | BeFree | Detail | |
| <0.001 | Compensatory Hyperinsulinemia | NA | BeFree | Detail | |
| <0.001 | attention deficit hyperactivity disorder | NA | BeFree | Detail | |
| 0.003 | major depressive disorder | NA | BeFree,LHGDN | Detail | |
| <0.001 | Cardiovascular morbidity | NA | BeFree | Detail | |
| <0.001 | Adenoma of large intestine | NA | BeFree | Detail | |
| 0.002 | Age at menarche | NA | GAD | Detail | |
| <0.001 | Sporadic Breast Carcinoma | NA | BeFree | Detail | |
| <0.001 | Epithelioma | NA | BeFree | Detail | |
| <0.001 | renal carcinoma | NA | BeFree | Detail | |
| <0.001 | Secondary Peritonitis | NA | BeFree | Detail | |
| <0.001 | Diabetic foot ulcer | NA | BeFree | Detail | |
| 0.150 | Mammary Neoplasms | NA | BeFree,CTD_human,GAD,LHGDN | Detail | |
| <0.001 | Mammary Tumorigenesis | NA | BeFree | Detail | |
| <0.001 | Skin Carcinogenesis | NA | BeFree | Detail | |
| <0.001 | Xenograft Model | Autophagy induction by leptin contributes to suppression of apoptosis in cancer ... | BeFree | 25704884 | Detail |
| 0.009 | colorectal cancer | NA | BeFree,GAD | Detail | |
| <0.001 | Neoplasms, Intracranial | NA | BeFree | Detail | |
| <0.001 | Chronic Kidney Diseases | Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. | BeFree | 25010649 | Detail |
| <0.001 | Glioblastoma multiforme | NA | BeFree | Detail | |
| <0.001 | androgen independent prostate cancer | NA | BeFree | Detail | |
| <0.001 | Familial Partial Lipodystrophy, Type 1 | NA | BeFree | Detail | |
| 0.002 | uterine corpus cancer | Correlation analysis between the expressions of leptin and its receptor (ObR) an... | BeFree | 25171477 | Detail |
| <0.001 | Osteophyte | NA | BeFree | Detail | |
| 0.004 | coronary artery disease | NA | BeFree,LHGDN | Detail | |
| 0.003 | Precursor Cell Lymphoblastic Leukemia Lymphoma | NA | BeFree,LHGDN | Detail | |
| 0.009 | liver carcinoma | In the present study, we investigated the role of autophagy in leptin-induced ca... | BeFree,LHGDN | 25704884 | Detail |
| <0.001 | bulimia nervosa | NA | BeFree | Detail | |
| 0.001 | Pediatric Obesity | NA | BeFree | Detail | |
| <0.001 | Allergic rhinitis (disorder) | NA | BeFree | Detail | |
| <0.001 | Adiponectin deficiency | NA | BeFree | Detail | |
| 0.002 | Steatohepatitis | NA | BeFree | Detail | |
| <0.001 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | NA | BeFree | Detail | |
| 0.002 | Weight Loss Adverse Event | NA | GAD | Detail | |
| 0.019 | Weight Gain Adverse Event | NA | GAD | Detail | |
| 0.002 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | NA | GAD | Detail | |
| 0.080 | Abdominal obesity metabolic syndrome | NA | MGD | Detail | |
| <0.001 | Obesity, Visceral | NA | BeFree | Detail | |
| <0.001 | Plaque, Amyloid | NA | BeFree | Detail | |
| <0.001 | Pulmonary arterial hypertension | We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti... | BeFree | 25745038 | Detail |
| 0.001 | Nonalcoholic Steatohepatitis | Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH... | BeFree | 25501551 | Detail |
| <0.001 | Hydatidiform mole, recurrent, 1 | NA | BeFree | Detail | |
| <0.001 | Lipomatosis, Multiple | NA | BeFree | Detail | |
| 0.002 | granulomatosis with polyangiitis | NA | GAD | Detail | |
| <0.001 | Diabetic Heart Disease | NA | BeFree | Detail | |
| <0.001 | LEPTIN RECEPTOR DEFICIENCY | NA | BeFree | Detail | |
| 0.008 | Infection | NA | LHGDN | Detail | |
| <0.001 | Dowling-Degos disease | In the DDD group, there were 10 cytokines and growth factors with significantly ... | BeFree | 25365709 | Detail |
| <0.001 | Insulin resistance syndrome | NA | BeFree | Detail | |
| <0.001 | Isolated somatotropin deficiency | NA | BeFree | Detail | |
| <0.001 | Pulmonary hypertension, primary, 1, with hereditary hemorrhagic telangiectasia | We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti... | BeFree | 25745038 | Detail |
| <0.001 | Obesity in animals | NA | BeFree | Detail | |
| 0.002 | congenital leptin deficiency | NA | BeFree | Detail | |
| 0.003 | adenocarcinoma | NA | BeFree,LHGDN | Detail | |
| <0.001 | Adenolymphoma | NA | BeFree | Detail | |
| 0.001 | adenoma | Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly ... | BeFree | 25313911 | Detail |
| <0.001 | Adrenal Gland Neoplasms | We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose t... | BeFree | 25313911 | Detail |
| 0.003 | congenital adrenal hyperplasia | NA | LHGDN | Detail | |
| 0.002 | Albuminuria | NA | GAD | Detail | |
| <0.001 | Alcoholic Intoxication, Chronic | These findings point towards a pathophysiological relevance of changes in DNA me... | BeFree | 25462909 | Detail |
| 0.201 | Alzheimer's disease | We also discuss relevant issues such as the role of leptin, insulin and renin-an... | BeFree,CTD_human,RGD | 25084549 | Detail |
| 0.201 | Alzheimer's disease | Alterations in brain leptin signalling in spite of unchanged CSF leptin levels i... | BeFree,CTD_human,RGD | 25453257 | Detail |
| 0.002 | amyotrophic lateral sclerosis | NA | GAD | Detail | |
| <0.001 | anemia | NA | BeFree | Detail | |
| <0.001 | Anemia of chronic disease | NA | BeFree | Detail | |
| <0.001 | Aneurysm | NA | BeFree | Detail | |
| 0.003 | Angina, Unstable | NA | LHGDN | Detail | |
| 0.007 | Anorexia | NA | BeFree,LHGDN | Detail | |
| 0.015 | anorexia nervosa | Plasma Aβ40 levels were similar between patients and controls, while a marked re... | BeFree,LHGDN | 25998413 | Detail |
| 0.008 | Anoxia | NA | GAD,LHGDN | Detail | |
| <0.001 | Anxiety Disorders | NA | BeFree | Detail | |
| <0.001 | aortic aneurysm | NA | BeFree | Detail | |
| 0.003 | arteriosclerosis | NA | BeFree | Detail | |
| 0.003 | arthritis | SLE patients in the highest quartile leptin levels (≥32.5 ng/mL) were significan... | BeFree,LHGDN | 25383655 | Detail |
| 0.004 | rheumatoid arthritis | NA | BeFree,LHGDN | Detail | |
| 0.008 | asthma | NA | BeFree,GAD,LHGDN | Detail | |
| 0.003 | atherosclerosis | NA | BeFree | Detail | |
| 0.120 | autistic disorder | NA | CTD_human | Detail | |
| 0.001 | Autoimmune Diseases | NA | BeFree | Detail | |
| <0.001 | Mental disorders | NA | BeFree | Detail | |
| 0.006 | Behcet Syndrome | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | bipolar disorder | Metabolic syndrome and related variables, insulin resistance, leptin levels, and... | BeFree | 26083812 | Detail |
| 0.003 | Malignant neoplasm of urinary bladder | NA | BeFree,GAD | Detail | |
| 0.080 | Body Weight Changes | NA | RGD | Detail | |
| 0.003 | Metabolic Bone Disorder | NA | LHGDN | Detail | |
| <0.001 | Brain Neoplasms | NA | BeFree | Detail | |
| 0.023 | Malignant neoplasm of breast | These preliminary findings may support the hypothesis that genetic variation in ... | BeFree,GAD | 24825736 | Detail |
| 0.023 | Malignant neoplasm of breast | Signal transducer and activator of transcription 3 (STAT3) has been linked to br... | BeFree,GAD | 25481644 | Detail |
| 0.023 | Malignant neoplasm of breast | Leptin induces SK1 expression and activation in ER-negative breast cancer cell l... | BeFree,GAD | 25482303 | Detail |
| 0.023 | Malignant neoplasm of breast | The LEP G-2548A gene polymorphism is associated with age at menarche and breast ... | BeFree,GAD | 25510398 | Detail |
| 0.023 | Malignant neoplasm of breast | In the present study, we investigated the role of autophagy in leptin-induced ca... | BeFree,GAD | 25704884 | Detail |
| <0.001 | Bulimia | NA | BeFree | Detail | |
| 0.002 | Cachexia | NA | BeFree | Detail | |
| 0.002 | Malignant tumor of colon | NA | BeFree | Detail | |
| 0.002 | Malignant neoplasm of endometrium | Correlation analysis between the expressions of leptin and its receptor (ObR) an... | BeFree | 25171477 | Detail |
| <0.001 | Non-small cell lung carcinoma | NA | BeFree | Detail | |
| <0.001 | renal cell carcinoma | NA | BeFree | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| The incidence of leptin gene G2548A homozygous mutant AA polymorphism was significantly increased in... | DisGeNET | Detail |
| Leptin, a possible mediator between energy homeostasis, inflammation and cardiovascular disease (CVD... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| CA supplementation in vivo decreased the number of colon tumors and reduced circulating concentratio... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-ana... | DisGeNET | Detail |
| Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-ana... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than... | DisGeNET | Detail |
| Recently, a biological link between leptin resistance and depression has been proposed. | DisGeNET | Detail |
| Recently, a biological link between leptin resistance and depression has been proposed. | DisGeNET | Detail |
| In the prospective Pune Maternal Nutrition Study, we found that small and thin Indian babies were mo... | DisGeNET | Detail |
| In the prospective Pune Maternal Nutrition Study, we found that small and thin Indian babies were mo... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and w... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Black and tan, brachyury (BTBR) mice deficient for the leptin receptor (ob/ob) develop many of the p... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We now describe two siblings, a 9-year-old girl and a 6-year-old boy with severe early-onset obesity... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| When leptin and leptin receptor genes were considered together, synergistic interaction was observed... | DisGeNET | Detail |
| Association of two well-defined polymorphisms in leptin and leptin receptor genes with hypertension ... | DisGeNET | Detail |
| Importantly, we demonstrate the efficacy of two curative strategies using a soluble Ob neutraliser a... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Leptin is also involved in the progression of renal disease through its pro-fibrotic and pro-hyperte... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therefore, have investigated whether or not the expression levels, of selected genes [tumor necrosis... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Imatinib itself may increase leptin levels, and, as leptin plays an active role in the pathophysiolo... | DisGeNET | Detail |
| Therapeutic management of dyslipidemia in patients with lipodystrophy is primarily based on specific... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Serum leptin levels, leptin receptor gene (LEPR) polymorphism, and the risk of systemic lupus erythe... | DisGeNET | Detail |
| The expression of adiponectin and resistin was increased in both sera and urine from LN patients, wh... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Also, our results provide evidence that LEP A19G polymorphism is associated with decreased risk of N... | DisGeNET | Detail |
| LEP and LEPR polymorphisms in non-Hodgkin lymphoma risk: a systematic review and pooled analysis. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and w... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Leptin and ObR are overexpressed in EC, and their expressions are associated with malignancy, invasi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Among 73 children with severe obesity (BMI SDS > 3.0), we identified 22 probands and 5 relatives, ca... | DisGeNET | Detail |
| Therefore, in the present study, we investigated the hypothesis that hypoxia may drive the expressio... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Notably, patients with RTT have evidence of mitochondrial dysfunction, as well as abnormal levels of... | DisGeNET | Detail |
| We investigated the associations of the LEP-2548A/G and HTR2C-759C/T polymorphisms with long-term cl... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of leptin levels with pathogenetic risk of coronary heart disease and stroke: a meta-ana... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| GO terms relevant to translation and metabolic process and their related genes CREB1, ribosomal prot... | DisGeNET | Detail |
| Evaluation of leptin and leptin receptor gene 3' UTR polymorphisms in essential hypertension. | DisGeNET | Detail |
| Our findings support the contributory role of the II/I polymorphism in leptin gene in the pathogenes... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obe... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti-inflammatory target... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The significance of this work thus extends beyond understanding E. histolytica susceptibility by als... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Black and tan, brachyury (BTBR) mice deficient for the leptin receptor (ob/ob) develop many of the p... | DisGeNET | Detail |
| Interestingly, inhibition of autophagic process by treatment with inhibitors and LC3B gene silencing... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Polymorphisms of the leptin and HTR2C genes and clozapine-induced weight change and baseline BMI in ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Therapeutic management of dyslipidemia in patients with lipodystrophy is primarily based on specific... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Leptin Is Oversecreted by Respiratory Syncytial Virus-Infected Bronchial Epithelial Cells and Regula... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology i... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Here we examined the correlation between obesity and insulin resistance with the methylation frequen... | DisGeNET | Detail |
| Expression of leptin, NGF and adiponectin in metabolic syndrome. | DisGeNET | Detail |
| The available relatives of the same family were interviewed (DSM-IV-R) and assessed in fasting condi... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association of the Ala16Val MnSOD gene polymorphism with plasma leptin levels and oxidative stress b... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| These preliminary findings may support the hypothesis that genetic variation in adipokine genes modi... | DisGeNET | Detail |
| Signal transducer and activator of transcription 3 (STAT3) has been linked to breast cancer progress... | DisGeNET | Detail |
| Leptin induces SK1 expression and activation in ER-negative breast cancer cell lines MDAMB-231 and B... | DisGeNET | Detail |
| The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibilit... | DisGeNET | Detail |
| In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferat... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The percentages of leptin and ObR were significantly higher in the patients with lymph node metastas... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
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| Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft ... | DisGeNET | Detail |
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| Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. | DisGeNET | Detail |
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| Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology i... | DisGeNET | Detail |
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| In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferat... | DisGeNET | Detail |
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| We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti-inflammatory target... | DisGeNET | Detail |
| Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experime... | DisGeNET | Detail |
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| In the DDD group, there were 10 cytokines and growth factors with significantly increased expression... | DisGeNET | Detail |
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| We demonstrate here that Ob/ObR-b axis may represent anti-proliferative and anti-inflammatory target... | DisGeNET | Detail |
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| Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosteron... | DisGeNET | Detail |
| We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding ad... | DisGeNET | Detail |
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| These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP... | DisGeNET | Detail |
| We also discuss relevant issues such as the role of leptin, insulin and renin-angiotensin signaling ... | DisGeNET | Detail |
| Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's diseas... | DisGeNET | Detail |
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| Plasma Aβ40 levels were similar between patients and controls, while a marked reduction was observed... | DisGeNET | Detail |
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| SLE patients in the highest quartile leptin levels (≥32.5 ng/mL) were significantly more likely to h... | DisGeNET | Detail |
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| Metabolic syndrome and related variables, insulin resistance, leptin levels, and PPAR-γ2 and leptin ... | DisGeNET | Detail |
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| These preliminary findings may support the hypothesis that genetic variation in adipokine genes modi... | DisGeNET | Detail |
| Signal transducer and activator of transcription 3 (STAT3) has been linked to breast cancer progress... | DisGeNET | Detail |
| Leptin induces SK1 expression and activation in ER-negative breast cancer cell lines MDAMB-231 and B... | DisGeNET | Detail |
| The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibilit... | DisGeNET | Detail |
| In the present study, we investigated the role of autophagy in leptin-induced cancer cell proliferat... | DisGeNET | Detail |
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| Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology i... | DisGeNET | Detail |
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Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386596107 dbSNP
- Genome
- hg38
- Position
- chr7:128,241,278-128,257,629
- Variant Type
- snv
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